A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
- Summary
- The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and activity of single-agent divarasib or combined with other anti-cancer therapies in participants with previously untreated, advanced or metastatic non-small cell lung cancer (NSCLC).
- Acronym
- KRAScendo 170
- Short title
- A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
- Official title
- A Phase Ib/II, Open-Label, Multicenter Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Patients With Previously Untreated Advanced Or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
- Control arm
- Open label
- Registry reports results
- Listing at source
- Listed
- Recruitment status
- Recruiting
- Phase
- Phase 1/Phase 2
- Study type
- Interventional
- Completion date
- 2032-01-29
- First posted
- 2023-03-29
- Registry last updated
- 2026-08-10
- Primary completion date
- 2032-01-29
- Start date
- 2023-06-20
- Participants
- Participant count basis
- Estimated
- Planned participants
- Protocol amendments
- Number of sites
- Data monitoring committee
- Registry sponsor category
- Industry
- Lead sponsor
- Hoffmann-La Roche
- Source registry
- ClinicalTrials.gov
- Registry ID
- NCT05789082
- ClinicalTrials.gov ID
- NCT05789082
- Registry record
- Open registry record
- Allocation
- Randomised
- Model
- Parallel groups
- Purpose
- Treatment
- Masking
- No masking
Percentage of Participants with Adverse Events (AEs)
Timeframe: Baseline until 60 days after the final dose of study treatment or until initiation of another anti-cancer therapy, whichever occurs first (up to approximately 5 years)
Objective Response Rate (ORR)
Timeframe: Approximately 5 years
The percentage of participants who experience a complete response or partial response, as determined by the investigator, according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.1
Duration of Response (DOR)
Timeframe: Approximately 5 years
The time from the first occurrence of a documented objective response to disease progression or death from any cause (whichever occurs first), as determined by the investigator according to RECIST v1.1
Progression Free Survival (PFS)
Timeframe: Approximately 5 years
The time from randomization, or date of first treatment for participants enrolled prior to the expansion stage, to the first occurrence of disease progression or death from any cause during the study (whichever occurs first), as determined by the investigator according to RECIST v1.1
Number of Participants Reporting Presence, Frequency, Severity, and/or Degree of Interference with Daily Function of Symptomatic Side Effects as Assessed Through the Patient-Reported Outcomes Common Terminology Criteria for Adverse Events (PRO-CTCAE)
Timeframe: Approximately 5 years
Change from Baseline in Symptomatic Side Effects, as Assessed Through use of the PRO-CTCAE
Timeframe: Baseline up to approximately 5 years
Percentage of Participants Reporting "Frequent" or "Almost Constant" Diarrhea During the First Three Cycles of Treatment According to the PRO-CTCAE Criteria
Timeframe: Approximately 5 years
Percentage of Participants Reporting "Severe" or "Very Severe" Nausea or Vomiting During the First Three Cycles of Treatment According to the PRO-CTCAE
Timeframe: Approximately 5 years
Frequency of Participant's Response of the Degree they are Troubled with Treatment Symptoms, as Assessed Through use of the Single-item European Organisation for Research and Treatment of Cancer (EORTC) Item List 46 (IL46)
Timeframe: Approximately 5 years
Plasma or CSF Concentration of Divarasib at Specified Timepoints
Timeframe: Approximately 5 years
Optional CSF samples may be collected at the time of disease progression or at any time during the study for participants who have provided written consent and if collection of CSF sample is deemed clinically feasible. Matched optional plasma samples may be drawn at the same time.
Identification of Divarasib Recommended Dose
Timeframe: Approximately 5 years
The recommended dose will be based upon the totality of safety, activity, and PK data.
Central Nervous System (CNS) Response
Timeframe: Approximately 5 years
Defined as the percentage of participants who experience a complete response or partial response in the brain, as determined by the investigator according to modified RECIST
- Sex
- All
- Age groups
- Adults, Older adults
- Minimum age
- 18 Years
- Healthy volunteers
- No
- Confirmation of Biomarker eligibility
- Pre-treatment tumor tissue along with an associated pathology report is required for all participants enrolled on study. Representative tumor specimens must be in formalin-fixed, paraffin embedded (FFPE) blocks (preferred) or 15 unstained, freshly cut, serial slides. Although 15 slides are required, if only 10 slides are available, the participant may be eligible for the study following consultation with the Sponsor.
- Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 or 1
- Histologically or cytologically documented locally advanced unresectable or metastatic NSCLC that is not eligible for curative surgery and/or definitive chemoradiotherapy
- No prior systemic treatment for advanced unresectable or metastatic NSCLC
- Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. Additionally, for participants in cohort D, measurable brain metastases defined as at least 5 millimeters and twice the slice thickness, but less than 20 mm, that is asymptomatic and does not require local therapy at the time of enrollment.
- Known concomitant second oncogenic driver with available targeted treatment
- Squamous cell histology NSCLC
- Symptomatic, untreated, or actively progressing CNS metastases (Cohorts A, B, and C)
- Prior treatment with a KRAS G12C inhibitor
- Known hypersensitivity to any of the components of divarasib or pembrolizumab; or known hypersensitivity to pemetrexed, carboplatin, or cisplatin (Cohort B only)
- History of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis, active tuberculosis, significant cardiovascular disease within 3 months prior to initiation of study treatment
- History of malignancy other than NSCLC within 5 years prior to initiation of study treatment, with the exception of malignancies with a negligible risk of metastasis or death (e.g., 5-year OS rate more >90%), such as adequately treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, localized prostate cancer, ductal breast carcinoma in situ, or Stage I uterine cancer
- Uncontrolled tumor related pain, pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures, uncontrolled or symptomatic hypercalcemia
- Co-morbid condition that is an absolute contraindication to treatment with corticosteroids
- Inability or unwillingness to take prophylactic treatments such as corticosteroids, anti-emetics, folic acid, or vitamin B12 supplementation.
- Participants with brain metastases for whom complete surgical resections is clinically appropriate
- City of Hope National Medical CenterDuarte, United StatesWithdrawn
- City of Hope - SeacliffHuntington Beach, United StatesWithdrawn
- City of Hope at Irvine LennarIrvine, United StatesWithdrawn
- UCSD Moores Cancer CenterLa Jolla, United StatesWithdrawn
- City of Hope - Long Beach ElmLong Beach, United StatesWithdrawn
- Yale Cancer CenterNew Haven, United StatesRecruiting
- Florida Cancer Specialists - SOUTH - SCRI - PPDSFort Myers, United StatesRecruiting
- Florida Cancer Specialists - NORTH - SCRI - PPDSSt. Petersburg, United StatesRecruiting
- Florida Cancer Specialists - EAST - SCRI - PPDSWest Palm Beach, United StatesRecruiting
- NYU Langone Hospital - Long IslandMineola, United StatesRecruiting
- NYU Cancer CenterNew York, United StatesRecruiting
- Mount SInai Medical CenterNew York, United StatesRecruiting
- Montefiore Medical Center - Montefiore Medical ParkThe Bronx, United StatesRecruiting
- MD Anderson Cancer CenterHouston, United StatesRecruiting
- Oncology & Hematology Associates of Southwest Virginia, IncBlacksburg, United StatesRecruiting
- Virginia Oncology AssociatesNorfolk, United StatesRecruiting
- Hospital BritanicoBuenos Aires, ArgentinaRecruiting
- Clinica Adventista BelgranoCiudad Autonoma Buenos Aires, ArgentinaRecruiting
- Centro Oncologico Riojano Integral (CORI)La Rioja, ArgentinaRecruiting
- Concord Repatriation General HospitalConcord, AustraliaCompleted
- Peter MacCallum Cancer CentreMelbourne, AustraliaRecruiting
- Alfred HealthMelbourne, AustraliaRecruiting
- Cliniques Universitaires St-LucBrussels, BelgiumRecruiting
- Jessa Zkh (Campus Virga Jesse)Hasselt, BelgiumRecruiting
- Clinique Ste-ElisabethNamur, BelgiumRecruiting
And 46 more, listed on the interactive page.
- Related resource (www.gene.com)
- 2023
- 2023-507171-22-00
- 2022-003048-28
Related records
Drugs (5)
Lead sponsors (1)
Conditions (1)
- Non-small cell lung carcinoma Primary condition