Multiple sclerosis
Therapeutic area
Immunology
Rare disease
Yes
- Definition
- A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Multiple sclerosis
- Therapeutic area
- Immunology
- multiple sclerosis
- generalised multiple sclerosis
- generalized multiple sclerosis
- Disease mechanisms
- Developmental
- Severity
- Severe
- Immunology
- Neurology
- MONDO ID
- MONDO:0005301
- Parent condition
- MONDO:0000568
Related records
Broader conditions (16)
- Autoimmune disease
- Autoimmune disorder of central nervous system
- Autoimmune disorder of the nervous system
- Brain disorder
- Central nervous system disorder
- CNS demyelinating autoimmune disease
- Demyelinating disease
- Demyelinating disease of central nervous system
- Disease
- Disease by body system or component
- Disease by developmental or physiological process
- Disorder of development or morphogenesis
- Human disease
- Immune system disorder
- Nervous system disorder
- Neurodegenerative disease
Narrower conditions (7)
- Chronic progressive multiple sclerosis
- Marburg acute multiple sclerosis
- Pediatric multiple sclerosis
- Primary progressive multiple sclerosis
- Progressive relapsing multiple sclerosis
- Relapsing-remitting multiple sclerosis
- Secondary progressive multiple sclerosis
Trials (3,136)
- " Treating MS Patients With Lower Extremity Spasticity Using Dysport"
- "Balance, Gait, and Motion Analysis in Multiple Sclerosis"
- "Evaluation of Usability and Safety of the Self-balancing Walking System Atalante in Patients With Multiple Sclerosis"
- "HB-adMSCs for the Treatment of Patients With Multiple Sclerosis"
- "Outwalk MS" - Benefits of Outdoor Walking in Multiple Sclerosis
- "Selfie" Videos: A Novel, Patient-centered, Comprehensive Approach to Measuring Function in MS
- [11C]-PBR28 Positron Emission Tomography Study to Evaluate the Effect of ABT 555 in Subjects With Relapsing Forms of Multiple Sclerosis
- [18F]PBR111 and Microglial Activation in Multiple Sclerosis
- 12-week Safety Evaluation of Oral CS-0777 in Multiple Sclerosis Patients
- 12-week Study to Evaluate RebiSmartâ„¢ Suitability for Self Injection in Relapsing Multiple Sclerosis.
- 3 Meter Backwards Walk Test and Multiple Sclerosis
- 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Multiple Sclerosis.
- 3D FLAIR Versus Coronal T2-WI MRI in Detecting Optic Neuritis (FLACON)
- 3D OPTIMIZED WMN MPRAGE Increased Detection of Focal Spinal Cord Lesion in Multiple Sclerosis (WHINUME)
- 3D Phase Sensitive Inversion Recuperation MRI to Detect and Characterize Multiple Sclerosis Spinal Cord Lesions
- 5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis
- A "negative"dendritic Cell-based Vaccine for the Treatment of Multiple Sclerosis: a First-in-human Clinical Trial
- A 12 -Month, Open-label, Multi-center Study to Explore the Health Outcomes of FTY720
- A 12 Week Randomized Open Label Parallel Group Multicenter Study to Evaluate Bioequivalence of 20 mg Subcutaneous Ofatumumab Injected by Pre-filled Syringe or Autoinjector in Adult RMS Patients
- A 3-year Multi-center Study to Describe Changes of OCT Parameters Under Treatment With Gilenya®
Approved drugs (35)
- Alemtuzumab
- Baclofen
- Cladribine
- Corticotropin
- Daclizumab
- Dalfampridine
- Dantrolene sodium
- Dexamethasone
- Dimethyl fumarate
- Diroximel fumarate
- Fingolimod hydrochloride
- Fingolimod lauryl sulfate
- Glatiramer acetate
- Interferon beta-1A
- Interferon beta-1B
- Lincomycin
- Methylprednisolone
- Methylprednisolone sodium succinate
- Mitoxantrone hydrochloride
- Monomethyl fumarate
Drugs in development (200)
- Abatacept Phase 2
- Acetaminophen Phase 3
- Acetazolamide Phase 2
- Acetylcysteine Phase 2
- Acyclovir sodium Phase 3
- Alfuzosin Phase 2
- Amantadine Phase 3
- Amantadine hydrochloride Phase 3
- Amifampridine Phase 3
- Amiselimod hydrochloride Phase 2
- Anakinra Phase 1
- Arbaclofen placarbil Phase 3
- Armodafinil Phase 2
- ASP-4058 Phase 1
- Aspirin Phase 3
- Atacicept Phase 2
- Atorvastatin Phase 2
- Azficel-T Phase 3
- Azithromycin Phase 2
- Belimumab Phase 2
Other linked drugs (7)
- Aspartic acid
- Gadolinium
- Gadoteridol
- Incobotulinumtoxina
- Leflunomide
- Sodium phosphate, dibasic, anhydrous
- TOL-101