Neurodegenerative disease
Therapeutic area
Neurology
Rare disease
No
- Definition
- A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function.
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- No
- Listing at source
- Listed
- Condition name
- Neurodegenerative disease
- Therapeutic area
- Neurology
- neurodegenerative disease
- degenerative disease
- brain degeneration
- central nervous system degenerative disorder
- central nervous system neurodegenerative disorder
- degenerative disorder of central nervous system
- cerebral degeneration disease
- All therapeutic areas
- Neurology
- Severity
- Severe
- MONDO ID
- MONDO:0005559
- Parent condition
- MONDO:0002602
Related records
Broader conditions (5)
- Central nervous system disorder
- Disease
- Disease by body system or component
- Human disease
- Nervous system disorder
Narrower conditions (920)
- AARS1-related leukoencephalopathy
- ABeta amyloidosis, Arctic type
- ABeta amyloidosis, dutch type
- ABeta amyloidosis, Iowa type
- ABeta amyloidosis, Italian type
- ABetaA21G amyloidosis
- ABetaL34V amyloidosis
- Abetalipoproteinemia
- ABri amyloidosis
- Aceruloplasminemia
- ACO2-related optic atrophy with or without extraocular features
- Acquired human prion disease
- Acquired motor neuron disease
- Acute disseminated encephalomyelitis
- Acute disseminated encephalomyelitis with anti-MOG antibodies
- Acute disseminated encephalomyelitis without anti-MOG antibodies
- Acute hemorrhagic leukoencephalitis
- Acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndrome
- Acute nonparalytic poliomyelitis
- Acute transverse myelitis with anti-MOG antibodies
Trials (442)
- [18F]MC225-PET in Neurodegenerative Disease
- [18F]NIDF PET Imaging in Tau-related Diseases
- [18F]THK-5351 Positron Emission Computed Tomography Study of Normal, Mild Cognitive Impairment, Alzheimer's Disease and Other Neurodegenerative Disease
- A 24-weeks, Multi-center, Randomized, Double-blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Donepezil Hydrochloride in Chinese Subjects With Severe Alzheimer's Disease
- A Biomarker Study of ATH434 in Participants With MSA
- A Biomarker-chip Assay in Preserved Red Blood Cells for the Diagnosis of Alzheimer's Disease
- A Bridging Study on Efficacy and Safety of [18F]Florbetaben PET for Diagnosis of Alzheimer Disease Subjects in Chinese Population
- A Double-Blind, Placebo-Controlled Safety and Efficacy Study of NA-831
- A Drug-Drug Interaction Study to Assess the CYP1A2 and CYP3A4 Interaction Potential of TEV-56286 (anle138b)
- A FIH Study to Assess the Safety and Tolerability of NS Intravenous NS101 Infusion
- A First in Human Study to Assess the Safety, Tolerability and Pharmacokinetics of ONO-2808-01 in Healthy Participants
- A First Time in Human Study of SNP318 as a Treatment for Neurodegenerative Diseases Including Alzheimer's Disease
- A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
- A First-in-Human Study of Single and Multiple Doses of anle138b in Healthy Subjects
- A Longitudinal Study of Amyotrophic Lateral Sclerosis (ALS) Biomarkers
- A Low-Cost Balance Training Platform Using Augmented Reality in Neurorehabilitation: a Usability Study
- A Multicenter Observational Study to Evaluate the Effectiveness of Patisiran in Patients With Polyneuropathy of ATTRv Amyloidosis With a V122I or T60A Mutation
- A Multicenter Prospective Registry for the Management of Degenerative Spine Disorders
- A New 3D Virtual Reality-based Upper Limb Training to Improve Dexterity in Parkinson's Disease
- A Open-label Food Effect Study With SEN0014196 in Subjects With Huntington Disease
Approved drugs (2)
- Amifampridine phosphate
- Flortaucipir F 18
Drugs in development (22)
- ANX-005 Phase 1
- Buntanetap Phase 1
- Buntanetap tartrate Phase 1
- Ceperognastat Phase 1
- Dalzanemdor Phase 1
- Dextromethorphan Phase 2
- Etazolate Phase 2
- Flurimedrimer (18F) Phase 1
- Fosmetpantotenate Phase 3
- Ismidenon Phase 1
- Latozinemab Phase 3
- Levacetylleucine Phase 1
- Niacinamide Phase 2
- Pegipanermin Phase 1
- Peptide T Phase 2
- Pimavanserin Phase 3
- Posatirelin Phase 3
- Taurursodiol Phase 1
- Tertomotide Phase 1
- Tilavonemab Phase 1
Other linked drugs (7)
- Amifampridine
- Citicoline
- Dopamine
- Emapunil
- Memantine
- NNZ-2591
- Pyrimidine