Hairy cell leukemia
Therapeutic area
Hematology
Rare disease
Yes
- Definition
- Hairy cell leukemia (HCL) is a rare type of leukemia in which abnormal B-lymphocytes are present in the bone marrow, spleen and peripheral blood. It is a slowly progressive chronic lymphocytic leukemia (CLL). The name comes from the abnormally shaped lymphocytes with hair-like projections.
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Hairy cell leukemia
- Therapeutic area
- Hematology
- hairy cell leukemia
- Hairy Cell Leukemia (HCL)
- Hairy-cell Leukemia
- HCL
- HCL-C
- leukemic reticuloendotheliosis
- Progressive Hairy Cell Leukemia, Initial Treatment
- Recurrent Hairy Cell Leukemia
- classic hairy cell leukaemia
- Severity
- Severe
- Hematology
- Immunology
- Oncology
Sources for recorded values
- MONDO ID
- MONDO:0018935
- Parent condition
- MONDO:0004948
Related records
Broader conditions (29)
- Acute disease
- Acute leukemia
- Acute lymphoblastic leukemia
- B-cell chronic lymphocytic leukemia
- B-cell neoplasm
- B-cell non-Hodgkin lymphoma
- Cancer or benign tumor
- Chronic leukemia
- Disease
- Disease by body system or component
- Disease by etiologic mechanism
- Hematologic disorder
- Hematopoietic and lymphoid cell neoplasm
- Hematopoietic and lymphoid system neoplasm
- Human disease
- Immune system disorder
- Indolent B-cell non-Hodgkin lymphoma
- Leukemia
- Leukocyte disorder
- Lymphoid hemopathy
Narrower conditions (4)
- Hairy cell leukemia variant
- Intrapelvic lymph node leukemic reticuloendotheliosis
- Refractory hairy cell leukemia
- Splenic manifestation of hairy cell leukemia
Trials (239)
- 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone Marrow Disorder
- 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Systemic Mastocytosis
- 3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer
- 506U78 in Treating Patients With Hematologic Cancer and Kidney or Liver Impairment
- A Phase I, Multicenter Dose Escalation Study in Patients With Hairy Cell Leukemia
- A Phase II Efficacy Study of Roferon-A in Hairy Cell Leukemia
- A Phase II Study of the BRAF Inhibitor, Vemurafenib, Plus Obinutuzumab in Patients With Previously Untreated Classical Hairy Cell Leukemia
- A Pilot Study of the Safety and Activity of Escalating Doses of ON 01910.Na in Patients With Relapsed Mantle Cell Lymphoma, Multiple Myeloma, Chronic Lymphocytic Leukemia, and Related Lymphoid Malignancies
- A Standardized Nursing Intervention Protocol for HCT Patients
- A Structured Walking Program or Standard Therapy in Cancer Patients Undergoing a Donor Bone Marrow Transplant
- A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies
- A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)
- A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab in Combination With Oral and Intravenous Anti-Neoplastic Agents in Adult Participants With Non-Hodgkin Lymphoma
- A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Escalating Doses of AGS67E Given as Monotherapy in Subjects With Refractory or Relapsed Lymphoid Malignancies
- A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies
- ACP-196 (Acalabrutinib) in Combination With Pembrolizumab, for Treatment of Hematologic Malignancies
- Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation
- Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies
- Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer
- Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma
Approved drugs (4)
- Cladribine
- Interferon alfa-2B
- Moxetumomab pasudotox
- Pentostatin
Drugs in development (26)
- Acetaminophen Phase 2
- Aspirin Phase 1
- Bendamustine Phase 2
- Binimetinib Phase 2
- BL22 Phase 2
- Brexucabtagene autoleucel Phase 2
- Busulfan Phase 2
- Cyclophosphamide Phase 2
- Dabrafenib Phase 2
- Dexamethasone Phase 1
- Diphenhydramine Phase 2
- Encorafenib Phase 2
- Epinephrine Phase 2
- Famotidine Phase 1
- Fludarabine Phase 2
- Interferon alfa-2A Phase 2
- LMB-2 Phase 2
- Obinutuzumab Phase 2
- Peginterferon alfa-2A Phase 2
- Plixorafenib Phase 1