Acute lymphoblastic leukemia
Therapeutic area
Hematology
Rare disease
Yes
- Definition
- Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia.
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Acute lymphoblastic leukemia
- Therapeutic area
- Hematology
- acute lymphoblastic leukemia
- acute lymphoblastic leukaemia (ALL)
- acute lymphoblastic leukaemia (disease)
- acute lymphoblastic leukemia (ALL)
- acute lymphoblastic leukemia (disease)
- acute lymphoblastic leukemia/lymphoma
- acute lymphocytic leukaemia
- Acute Lymphocytic Leukaemia Refractory
- acute lymphocytic leukemia
- Acute Lymphocytic Leukemia Refractory
- acute lymphocytic leukemias
- acute lymphogenous leukaemia
- acute lymphogenous leukemia
- acute lymphoid leukaemia
- acute lymphoid leukemia
- Acute Lymphoid Leukemia, Disease (disorder)
- ALL
- ALL - acute lymphocytic leukaemia
- ALL - acute lymphocytic leukemia
- leukemia, lymphoblastic, malignant
- Lymphoblastic Leukaemia
- Lymphoblastic Leukemia
- Lymphoblastic Leukemia Acute
- lymphoblastic leukemia, acute
- Lymphoblastic Leukemia, Acute Adult
And 8 more, listed on the interactive page.
- Severity
- Severe
- Hematology
- Oncology
Sources for recorded values
- MONDO ID
- MONDO:0004967
- Parent condition
- MONDO:0003538
Related records
Broader conditions (20)
- Acute disease
- Acute leukemia
- Cancer or benign tumor
- Disease
- Disease by body system or component
- Disease by etiologic mechanism
- Hematologic disorder
- Hematopoietic and lymphoid cell neoplasm
- Hematopoietic and lymphoid system neoplasm
- Human disease
- Leukemia
- Lymphoid hemopathy
- Lymphoid leukemia
- Lymphoid neoplasm
- Lymphoma
- Neoplasm
- Neoplasm of immature B and T cells
- Neoplastic disease or syndrome
- Non-Hodgkin lymphoma
- Precursor lymphoblastic lymphoma/leukemia
Narrower conditions (49)
- Acute biphenotypic leukemia
- Adult acute lymphoblastic leukemia
- Aggressive NK-cell leukemia
- B acute lymphoblastic leukemia with DUX4 rearrangement
- B acute lymphoblastic leukemia with PAX5 P80R mutation
- B-cell acute lymphoblastic leukemia
- B-cell acute lymphoblastic leukemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1)
- B-cell adult acute lymphocytic leukemia
- B-cell childhood acute lymphoblastic leukemia
- B-cell chronic lymphocytic leukemia
- B-cell prolymphocytic leukemia
- B-lymphoblastic leukemia with MEF2D rearrangement
- B-lymphoblastic leukemia with MYC rearrangement
- B-lymphoblastic leukemia with NUTM1 rearrangement
- B-lymphoblastic leukemia with PAX5alt
- B-lymphoblastic leukemia with TCF3-HLF fusion
- B-lymphoblastic leukemia with ZNF384 rearrangement
- B-lymphoblastic leukemia/lymphoma MLL rearranged
- B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1
- B-lymphoblastic leukemia/lymphoma with IAMP21
Trials (289)
- A Dose Escalation Study of Intensity Modulated Total Marrow Irradiation (IMRT-TMI) Followed by Fludarabine as a Myeloablative Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Relapsed and Refractory Hematologic Malignancies
- A Manualised Post-Traumatic Growth Intervention For People With Hematological Cancers In Greece
- A Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) in Children and Adults Receiving Treatment to Help Prepare Their Bodies for a Bone Marrow Transplant
- A Multi-center Retrospective Study of INO Treating B-ALL
- A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)
- A Novel CAR-T Combined Expression of IL-15 in the Treatment of Malignant Hematological Tumors
- A Pharmacokinetic and Pharmacodynamic Study of Vincristine in Children With Leukemia
- A Phase 1 Dose Escalation and Expanded Cohort Study of EPZ-5676 in the Treatment of Pediatric Patients With Relapsed/Refractory Leukemias Bearing a Rearrangement of the MLL Gene
- A Phase 1 Study Of FLAG Chemotherapy In Combination With Lisaftoclax And Pelcitoclax In Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia
- A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)
- A Phase 3 Study to Evaluate Marqibo® in the Treatment of Subjects ≥ 60 Years Old With Newly Diagnosed ALL
- A Phase I Study of WT1 Peptides to Induce Anti-Leukemia Immune Responses Following Transplantation
- A Pilot Study of Allopurinol As A Modifier of 6-MP Metabolism in Pediatric ALL
- A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation
- A Safety and Tolerability Study of CDX-301 With or Without Plerixafor for Stem Cell Mobilization in Matched Related Allogeneic Donor/Recipient Sibling Transplant Pairs
- A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combination With Either Chemotherapy or Venetoclax in Treatment of Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias or Solid Tumors
- A Study of Anti-CD19 CAR-T Cell Immunotherapy for Refractory /Relapsed B Cell Malignancies
- A Study of Low-Dose Decitabine in Relapsed or Refractory Acute Lymphocytic Leukemia (ALL)
- A Study of Revumenib in Combination With Chemotherapy in Participants With R/R Acute Leukemia
- A Study of the Safety and Pharmacokinetics of Venetoclax in Pediatric and Young Adult Patients With Relapsed or Refractory Malignancies
Approved drugs (18)
- Asparaginase
- Asparaginase erwinia chrysanthemi
- Blinatumomab
- Calaspargase pegol
- Chlorambucil
- Clofarabine
- Crisantaspase
- Cytarabine
- Dasatinib
- Dasatinib anhydrous
- Imatinib mesylate
- Inotuzumab ozogamicin
- Mercaptopurine
- Methotrexate
- Pegaspargase
- Plerixafor
- Ponatinib hydrochloride
- Rituximab
Drugs in development (316)
- 9-aminocamptothecin Phase 1
- ABT-751 Phase 1
- Acetaminophen Phase 2
- Aclarubicin Phase 3
- Acyclovir sodium Phase 1
- AFM-11 Phase 1
- AHN-12 Phase 1
- Aldesleukin Phase 1
- Alemtuzumab Phase 2
- Alisertib Phase 2
- Alisertib sodium Phase 2
- Allopurinol Phase 3
- Alovudine F-18 Early phase 1
- Alvocidib Phase 1
- Alvocidib hydrochloride Phase 1
- AMG-404 Phase 1
- Aminopterin Phase 2
- Aminopterin sodium Phase 2
- Amphotericin B Phase 2
- Amsacrine Phase 2
Other linked drugs (5)
- Epoetin beta
- Ergocalciferol
- Metformin hydrochloride
- Procarbazine
- Voriconazole