B-cell chronic lymphocytic leukemia
Therapeutic area
Hematology
Rare disease
Yes
- Definition
- B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma, and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia. The clinical course is extremely heterogeneous with survival ranging from a few months to several decades.
- Genetic basis
- Yes
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- B-cell chronic lymphocytic leukemia
- Therapeutic area
- Hematology
- B-cell chronic lymphocytic leukemia
- B cell CLL
- B cell chronic lymphocytic leukaemia
- B cell chronic lymphocytic leukemia
- B cell lymphocytic leukaemia
- B cell lymphocytic leukemia
- B-CLL
- B-cell CLL
- B-cell chronic lymphocytic leukemia
- B-cell chronic lymphogenous leukaemia
- B-cell chronic lymphogenous leukemia
- B-cell chronic lymphoid leukaemia
- B-cell chronic lymphoid leukemia
- B-cell lymphocytic leukaemia
- B-cell lymphocytic leukemia
- BCLL
- CLL
- Chronic Lymphocytic Leukemia
- chronic B-cell lymphocytic leukaemia
- chronic B-cell lymphocytic leukemia
- chronic lymphatic leukemia
- chronic lymphocytic leukaemia (CLL)
- chronic lymphocytic leukemia
- chronic lymphocytic leukemia (CLL)
- chronic lymphogenous leukaemia
And 6 more, listed on the interactive page.
- Severity
- Severe
- Hematology
- Immunology
- Oncology
- MONDO ID
- MONDO:0004948
- Parent condition
- MONDO:0001014
Related records
Broader conditions (28)
- Acute disease
- Acute leukemia
- Acute lymphoblastic leukemia
- B-cell neoplasm
- B-cell non-Hodgkin lymphoma
- Cancer or benign tumor
- Chronic leukemia
- Disease
- Disease by body system or component
- Disease by etiologic mechanism
- Hematologic disorder
- Hematopoietic and lymphoid cell neoplasm
- Hematopoietic and lymphoid system neoplasm
- Human disease
- Immune system disorder
- Indolent B-cell non-Hodgkin lymphoma
- Leukemia
- Leukocyte disorder
- Lymphoid hemopathy
- Lymphoid leukemia
Narrower conditions (8)
- Chronic lymphocytic leukemia/small lymphocytic lymphoma
- Chronic lymphocytic leukemia/small lymphocytic lymphoma with immunoglobulin heavy chain variable-region gene somatic hypermutation
- Hairy cell leukemia
- Hairy cell leukemia variant
- Intrapelvic lymph node leukemic reticuloendotheliosis
- Pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma
- Refractory hairy cell leukemia
- Splenic manifestation of hairy cell leukemia
Trials (1,312)
- "Don't Eat me" Signal in Hematological Malignancies: CD24 as New Target to Improve Anti-cancer Immunity.
- (CHANT)Real World Study of Duvelisib in the Treatment of Non-Hodgkin's Lymphoma (NHL)
- 17-N-Allylamino-17-Demethoxygeldanamycin and Bortezomib in Treating Patients With Relapsed or Refractory Hematologic Cancer
- 17-N-Allylamino-17-Demethoxygeldanamycin With or Without Rituximab in Treating Patients With Relapsed B-Cell Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia
- 19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers
- 5-Azacytidine (Azacytidine; Vidaza) in Chronic Lymphocytic Leukemia
- 64Cu-LLP2A for Imaging Hematologic Malignancies
- 8-Chloro-Adenosine in Chronic Lymphocytic Leukemia
- A Case Crossover Study of Intermittent Fasting in CLL/SLL
- A Clinical Study Evaluating the Safety and Efficacy of GT801 Injection in Adult Patients With Relapsed/Refractory CD19-positive B-cell Hematologic Malignancies and Autoimmune Hemolytic Anemia
- A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies
- A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006)
- A Clinical Trial on the Safety and Efficacy of TQB3909 Tablets in Patients With Recurrent or Refractory Chronic Lymphocytic Leukemia (CLL) /Small Lymphocytic Lymphoma (SLL) .
- A Clinical Trial to Evaluate Efficacy, Safety, and Pharmacokinetics of Gamunex in Participants With Chronic Lymphocytic Leukemia, Multiple Myeloma, or Non-Hodgkin Lymphoma
- A Clinical Trial to Evaluate the Efficacy and Safety of TQB3909 Tablets Versus Investigator's Choice in the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
- A Dose Escalation Study of Lenalidomide in Relapsed or Refractory B-cell Chronic Lymphocytic Leukemia
- A Dose Finding Study of CpG in Patients With Chronic Lymphocytic Leukemia Who Have Been Previously Treated
- A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
- A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies
- A Long-term Extension Study of PCI-32765 (Ibrutinib)
Approved drugs (13)
- Acalabrutinib
- Acalabrutinib maleate
- Alemtuzumab
- Bendamustine hydrochloride
- Duvelisib
- Duvelisib monohydrate
- Fludarabine phosphate
- Ibrutinib
- Idelalisib
- Obinutuzumab
- Ofatumumab
- Rituximab
- Venetoclax
Drugs in development (242)
- Acadesine Phase 1
- Acalisib Phase 1
- Acetaminophen Phase 1
- Adenosine Phase 1
- Agatolimod sodium Phase 1
- Aldesleukin Phase 2
- Allopurinol Phase 2
- Alvespimycin hydrochloride Phase 1
- Alvocidib Phase 2
- Alvocidib hydrochloride Phase 1
- AMG-319 Phase 1
- AN-9 Phase 2
- Anakinra Phase 1
- APG-2575 Phase 2
- Apolizumab Phase 2
- Arsenic trioxide Phase 2
- AT-7519 Phase 2
- Atezolizumab Phase 2
- Auranofin Phase 2
- Avadomide Phase 1
Other linked drugs (5)
- AR-42
- FBT-A05
- Lamivudine
- Orvacabtagene autoleucel
- Sotigalimab