Cholangiocarcinoma
Therapeutic area
Oncology
Rare disease
Yes
- Definition
- A carcinoma that arises from the intrahepatic biliary tree (intrahepatic cholangiocarcinoma) or from the junction, or adjacent to the junction, of the right and left hepatic ducts (hilar cholangiocarcinoma). Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor.
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Cholangiocarcinoma
- Therapeutic area
- Oncology
- cholangiocarcinoma
- bile duct cancer
- intrahepatic bile duct cancer (cholangiocarcinoma)
- CC
- CCA
- Cholangiocar.- intra/extrahepatic
- Cholangiocellular carcinoma
- cholangiocarcinoma
- cholangiocarcinoma, intrahepatic and extrahepatic bile ducts (adenocarcinoma)
- cholangiocarcinoma, malignant
- Severity
- Severe
- Endocrinology
- Gastroenterology
- Oncology
- MONDO ID
- MONDO:0019087
- Parent condition
- MONDO:0018536
Related records
Broader conditions (39)
- Adenocarcinoma
- Adenocarcinoma of gallbladder and extrahepatic biliary tract
- Bile duct adenocarcinoma
- Bile duct cancer
- Bile duct carcinoma
- Bile duct disorder
- Bile duct neoplasm
- Biliary tract cancer
- Biliary tract disorder
- Biliary tract neoplasm
- Cancer
- Cancer or benign tumor
- Carcinoma
- Carcinoma of gallbladder and extrahepatic biliary tract
- Carcinoma of liver and intrahepatic biliary tract
- Digestive system cancer
- Digestive system carcinoma
- Digestive system disorder
- Digestive system neoplasm
- Disease
Narrower conditions (7)
- Cholangiolocellular carcinoma
- Hilar cholangiocarcinoma
- Intrahepatic cholangiocarcinoma
- Mucinous intrahepatic cholangiocarcinoma
- Perihilar intrahepatic cholangiocarcinoma
- Sarcomatous intrahepatic cholangiocarcinoma
- Signet ring cell intrahepatic cholangiocarcinoma
Trials (807)
- [18F]FTT Positron Emission Tomography/Computed Tomography to Predict Treatment Response in Patients Scheduled to Receive Gemcitabine, Cisplatin, and Durvalumab for Newly Diagnosed Cholangiocarcinoma
- [68Ga]Ga-FAPI-46 Positron Emission Tomography (PET) Scan to Improve the Imaging of Pancreatic and Bile Duct Cancer
- 18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection
- 18F-FSPG PET in Imaging Patients With Liver Cancer Before Undergoing Surgery or Transplant
- 18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
- 89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors
- A Cell-free DNA Methylation Blood-Based Test for Biliary Tract Cancers Screening
- A Clinical Study of DEB-TACE Combined With Surufatinib and Camrelizumab in the Treatment of Inoperable or Metastatic ICC
- A Clinical Study to Evaluate the Efficacy and Safety of VG2025 in Intrahepatic Cholangiocarcinoma
- A Clinical Trial Evaluating the Safety and Efficacy of Intravenous HNF4α srRNA in Treating Advanced ICC Patients
- A Clinical Trial of Entinostat in Combination With Nivolumab for Patients With Previously Treated Unresectable or Metastatic Cholangiocarcinoma and Pancreatic Adenocarcinoma
- A Dose Finding Study of ZW49 in Patients With HER2-Positive Cancers
- A Feasibility Phase II Study in the Treatment of Resected Cholangiocarcinoma, Gallbladder, Pancreatic and Ampullary Cancers
- A First in Human Study of PLT012 in Participants With Solid Tumor Cancers
- A French Multicenter Observational Retrospective Study of Rare Primary Liver Cancers
- A Home-Based Approach Study to Evaluate the Efficacy and Safety of Alectinib in Locally-Advanced or Metastatic ALK-Positive Solid Tumors
- A Machine-learning Model to Predict Lymph Node Metastasis of Intrahepatic Cholangiocarcinoma
- A Multicenter, Prospective, Randomized, Open-label Phase Ib/II Study of Celecoxib Plus Pembrolizumab and Gemcitabine/Cisplatin Versus Pembrolizumab and Gemcitabine/Cisplatin in Patients With CK5/6-High Unresectable Locally Advanced or Metastatic Intrahepatic Cholangiocarcinoma
- A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer
- A Novel Patient Engagement Platform Among Patients With Gastrointestinal Malignancies
Approved drugs (4)
- Futibatinib
- Infigratinib phosphate
- Ivosidenib
- Pemigatinib
Drugs in development (90)
- ABC-294640 Phase 2
- Adebrelimab Phase 2
- Afatinib Phase 1
- Alectinib Phase 2
- Amcasertib Phase 2
- Atezolizumab Phase 2
- Axatilimab Phase 2
- Benmelstobart Phase 1
- Bevacizumab Phase 2
- Bintrafusp alfa Phase 2
- Cadonilimab Phase 2
- Calcitriol Phase 2
- Camrelizumab Phase 2
- Capecitabine Phase 3
- Carboplatin Phase 3
- Catequentinib Phase 1
- CDX-1140 Phase 1
- CDX-301 Phase 1
- Ceralasertib Phase 2
- Ceritinib Phase 2
Other linked drugs (2)
- DKN-01
- Zenocutuzumab