CDK6

ENSG00000105810
Target class
Kinase
Chromosome
7
Approved drugs
6
Clinical candidates (approved and in development)
12

Approved drugs
6
Clinical candidates (approved and in development)
12

Chemical probe available
Yes

Other names
  • PLSTIRE
Target name
CDK6
Gene name
Cyclin dependent kinase 6
Gene symbol
CDK6
Protein name
Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)

Gene biotype
Protein coding
Gene family
Cyclin dependent kinases
Target class
Kinase
Target type
Human gene

Tissues expressed in
53
Protein localisation evidence grade
Supported
Highest tissue expression
32.3
Tissue specificity (Gini)
0.363
Tissue specificity (tau)
0.83

KEGG gene identifiers
  • hsa:1021
Protein interaction confidence
0.863049
Protein interaction partners
61

  • R-HSA-2559580
  • R-HSA-2559582
  • R-HSA-2559585
  • R-HSA-69231
  • R-HSA-8934593
  • R-HSA-9630794
  • R-HSA-9632700
  • R-HSA-9661069
  • R-HSA-9754119

End position
92836591
Start position
92604921
Chromosome
7
Strand
Reverse

Ensembl gene ID
ENSG00000105810
HGNC ID
HGNC:1777
www.genenames.org
NCBI Gene ID
1021
UniProt ID
Q00534

  • Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (PubMed:23918663). .
  • Cytosol
  • Nucleoplasm

Publication evidence

Tissue specificity (tau)
0.829937
Expression inequality (Gini)
0.363312

Expression in transcripts per million

Cells - EBV-transformed lymphocytes
32.3
Cells - Cultured fibroblasts
19.67
Skin - Not Sun Exposed (Suprapubic)
11.33
Skin - Sun Exposed (Lower leg)
10.28
Cervix - Ectocervix
9.84

Expression in transcripts per million

  • Cells - EBV-transformed lymphocytes32.3
  • Cells - Cultured fibroblasts19.67
  • Skin - Not Sun Exposed (Suprapubic)11.33
  • Skin - Sun Exposed (Lower leg)10.28
  • Cervix - Ectocervix9.84
  • Artery - Tibial9.74
  • Minor Salivary Gland9.24
  • Vagina8.97
  • Adrenal Gland8.61
  • Artery - Coronary8.36
  • Nerve - Tibial8.34
  • Cervix - Endocervix8.16
  • Artery - Aorta7.71
  • Stomach7.68
  • Esophagus - Muscularis7.66
  • Lung7.52
  • Esophagus - Gastroesophageal Junction7.29
  • Small Intestine - Terminal Ileum7.25
  • Colon - Sigmoid6.45
  • Bladder6.37
  • Colon - Transverse6.15
  • Esophagus - Mucosa5.96
  • Adipose - Visceral (Omentum)5.86
  • Spleen5.49
  • Adipose - Subcutaneous5.37

And 29 more, listed on the interactive page.

  • regulation of catalytic activity

    Studies

    • biochemical: NVS_ENZ_hCDK6, is one of one assay component(s) measured or calculated from the NVS_ENZ_hCDK6 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology.

    Biological samples

    • cell-free
    Evidence source
    www.epa.gov

Related records

Trials (777)

Drugs (12)