Synucleinopathy
Therapeutic area
Metabolic Disease
Rare disease
No
- Definition
- A neurodegenerative disease that is characterized by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibers or glial cells. [url:http://en.wikipedia.org/wiki/Synucleinopathies ]
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- No
- Listing at source
- Listed
- Condition name
- Synucleinopathy
- Alternative names
- synucleinopathy
- Therapeutic area
- Metabolic Disease
- Severity
- Severe
- Metabolic Disease
- Neurology
Sources for recorded values
- MONDO ID
- MONDO:0000510
- Parent condition
- MONDO:0005559
Related records
Broader conditions (10)
- Central nervous system disorder
- Disease
- Disease by body system or component
- Disease by developmental or physiological process
- Disease by molecular mechanism
- Human disease
- Metabolic disease
- Nervous system disorder
- Neurodegenerative disease
- Proteostasis deficiencies
Narrower conditions (12)
- Autosomal dominant striatal neurodegeneration type 1
- Familial infantile bilateral striatal necrosis
- Lewy body dementia
- Multiple system atrophy
- Multiple system atrophy, cerebellar type
- Multiple system atrophy, parkinsonian type
- Pure autonomic failure
- Striatal degeneration, autosomal dominant
- Striatal degeneration, autosomal dominant 2
- Striatonigral degeneration
- Striatonigral degeneration, childhood-onset
- Striatonigral degeneration, infantile, mitochondrial
Trials (37)
- A Biomarker Study of ATH434 in Participants With MSA
- A Clinical Study of the Efficacy of Idebenone in the Treatment of iRBD Into Synucleinopathies
- A Comprehensive, Multimodal Characterization of Prodromal PD in Subjects With RBD
- A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)
- Alpha-Synuclein PET/CT in Various α-Syn-Related Disease
- Ambroxol to Slow Progression in Parkinson Disease
- An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD)
- An Observational Study of Parkinson's Disease and Other Synucleinopathies (EASE-PD)
- Application of 18F-CP6A PET Imaging in Synucleinopathies
- Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies
- Continued Evaluation of Patients With Parkinson's Disease Who Previously Received BRT-DA01
- Digital Diagnostics and Intervention Services for Parkinson's Disease
- Efficacy and Safety of Rasagiline in Prodromal Parkinson's Disease
- Exploring the Relationship Between Alpha-synucleinopathy Related Non-motor Symptom and Post-op. Delirium in Elderly Patients With Spine Surgery
- Immersive Virtual Reality Bicycling for Persons With Parkinson's Disease
- Intensive Multidisciplinary Rehabilitation and Biomarkers in Parkinson's Disease
- Longitudinal Tracking of Patients Diagnosed With Neurodegenerative Movement Disorders
- Microstructural and Sodium 7 Tesla Brain MRI in Idiopathic REM Sleep Behaviour Disorder
- Multiple N-of-1 Trials of (Intermittent) Hypoxia Therapy in Parkinson's Disease
- Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
Drugs in development (1)
- Idebenone Phase 2