Papillary renal cell carcinoma
Therapeutic area
Oncology
Rare disease
Yes
- Definition
- A rare subtype of renal cell carcinoma, arising from the renal tubular epithelium and showing a papillary growth pattern, which typically manifests with hematuria, flank pain, palpable abdominal mass or nonspecific symptoms, such as fatigue, weight loss or fever. Symptoms related to metastatic spread, such as bone pain or persistent cough, are frequently associated since early diagnosis is not common. It is typically multifocal, bilateral, and in most cases sporadic, although different hereditary syndromes, such as Hereditary leiomyoma renal cell carcinoma, Birt-Hogg-DubC) syndrome and Tuberous sclerosis, may predispose to the development of papillary renal cell carcinoma.
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Papillary renal cell carcinoma
- Therapeutic area
- Oncology
- papillary renal cell carcinoma
- HPRCC
- chromophil carcinoma of kidney
- chromophil carcinoma of the kidney
- chromophil renal cell carcinoma
- papillary (chromophil) renal cell carcinoma
- papillary renal cell adenocarcinoma
- papillary renal cell cancer
- papillary renal cell carcinoma
- renal cell carcinoma, papillary, type 1
- RCCP
- RCCP1
- chromophil RCC
- papillary renal carcinoma, malignant - (subtype)
- papillary renal cell carcinoma, bilateral - (subtype)
- papillary renal cell carcinoma, familial - (subtype)
- papillary renal cell carcinoma, multiple - (subtype)
- papillary renal cell carcinoma, sporadic - (subtype)
- renal adenocarcinoma
- renal cell carcinoma, papillary, 1
- Severity
- Terminal
- Nephrology
- Oncology
- MONDO ID
- MONDO:0017884
- Parent condition
- MONDO:0002512
Related records
Broader conditions (24)
- Adenocarcinoma
- Cancer
- Cancer or benign tumor
- Carcinoma
- Disease
- Disease by body system or component
- Disease by etiologic mechanism
- Epithelial neoplasm
- Glandular cell neoplasm
- Human disease
- Kidney cancer
- Kidney disorder
- Kidney neoplasm
- Malignant urinary system neoplasm
- Neoplasm
- Neoplastic disease or syndrome
- Papillary adenocarcinoma
- Papillary carcinoma
- Papillary epithelial neoplasm
- Renal carcinoma
Narrower conditions (1)
- Hereditary papillary renal cell carcinoma
Trials (29)
- A Dose Escalation, Safety and Activity Study of CDX-014 in Patients With Renal Cell Carcinoma and Ovarian Clear Cell Carcinoma
- A Phase I Study of SIM0505 in Participants With Advanced Solid Tumors
- A Phase II Study of GSK1363089 (Formerly XL880) for Papillary Renal-Cell Carcinoma (PRC)
- A Phase II Trial to Evaluate the Efficacy of AZD6094 (HMPL-504) in Patients With Papillary Renal Cell Carcinoma (PRCC)
- A Study of Nivolumab In Combination With Cabozantinib in Patients With Non-Clear Cell Renal Cell Carcinoma
- An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy
- Axitinib in1st Line Treatment for Patients With Advanced or Metastatic Papillary Renal Cell Carcinoma
- Cabozantinib In Combo With NIVO + IPI In Advanced NCCRCC
- Cabozantinib or Sunitinib Malate in Treating Participants With Metastatic Variant Histology Renal Cell Carcinoma
- CBM588 in Combination With Nivolumab and Cabozantinib for the Treatment of Advanced or Metastatic Kidney Cancer
- Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors
- Identification of Novel High Quality Methylated DNA Markers in Renal Tumors: Whole Methylome Discovery, Tissue Validation, and Feasibility Testing In Blood and Urine, The INQUIRE Study
- Multi-classifier System for Stratifying Stage III Papillary Renal Cell Carcinoma of Receiving Adjuvant Therapy
- Palbociclib and Sasanlimab for the Treatment of Advanced Clear Cell Renal Cell Carcinoma (ccRCC) or Papillary Renal Cell Carcinoma (pRCC)
- Pamiparib and Temozolomide for the Treatment of Hereditary Leiomyomatosis and Renal Cell Cancer
- Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer
- Real World Study of Effectiveness of Sunitinib or Sorafenib to Chinese Unresectable Locally Advanced or Metastatic PRCC
- Savolitinib Plus Durvalumab Versus Sunitinib and Durvalumab Monotherapy in MET-Driven, Unresectable and Locally Advanced or Metastatic PRCC
- Sorafenib and Interferon Alfa in Treating Patients With Locally Advanced or Metastatic Kidney Cancer
- Sorafenib Tosylate and Bevacizumab in Treating Patients With Advanced Kidney Cancer
Approved drugs (9)
- Axitinib
- Bevacizumab
- Cabozantinib S-malate
- Nivolumab
- Pazopanib hydrochloride
- Pembrolizumab
- Sorafenib tosylate
- Sunitinib
- Sunitinib malate
Drugs in development (10)
- Atezolizumab Phase 3
- Cabozantinib Phase 3
- Carotuximab Phase 2
- CDX-014 Phase 1
- Crizotinib Phase 2
- Durvalumab Phase 3
- Erlotinib hydrochloride Phase 2
- Interferon alfa Phase 3
- Savolitinib Phase 3
- Tivantinib Phase 2