Huntington disease
Therapeutic area
Neurology
Rare disease
Yes
- Definition
- Huntington disease (HD) is a rare neurodegenerative disorder of the central nervous system characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia.
- Genetic basis
- Yes
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Huntington disease
- Therapeutic area
- Neurology
- Huntington disease
- HD
- Huntington chorea
- Huntington disease
- Huntington's Disease
- Huntington's chorea
- Huntington's disease
- All therapeutic areas
- Neurology
- Severity
- Severe
- Genetic
- Hereditary
- MONDO ID
- MONDO:0007739
- Parent condition
- MONDO:0000167
Related records
Broader conditions (13)
- Central nervous system disorder
- Disease
- Disease by body system or component
- Disease by etiologic mechanism
- Disease of genetic or genomic mechanism
- Hereditary disease
- Hereditary neurological disease
- Human disease
- Huntington disease and related disorders
- Inherited neurodegenerative disorder
- Movement disorder
- Nervous system disorder
- Neurodegenerative disease
Narrower conditions (2)
- Juvenile Huntington disease
- Westphal disease
Trials (297)
- [PETDE10] Imaging of PDE10A Enzyme Levels in Huntington's Disease Gene Expansion Carriers and Healthy Controls With PET.
- 28-Day Study of SAGE-718 on Functioning Capacity in Participants With Huntington's Disease
- 31P-MRS and Huntington Disease
- A Biospecimen and Clinical Data Study on Patients for Drug & Biomarker Discovery
- A Clinical Study in Participants With Huntington's Disease (HD) to Assess Efficacy and Safety of Three Oral Doses of Laquinimod
- A Comparative Phase 2 Study Assessing the Efficacy of Triheptanoin, an Anaplerotic Therapy in Huntington's Disease
- A Dose Range Finding Study With Open-Label Extension to Evaluate the Safety of Oral LMI070/Branaplam in Early Manifest Huntington's Disease
- A Dose-escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetic of LPM3770164 in Healthy Subjects
- A First-in-human Study of the Effects of SRP-1005 in Participants With Huntington's Disease
- A Open-label Food Effect Study With SEN0014196 in Subjects With Huntington Disease
- A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions
- A Phase 1 Study To Evaluate The Effect Of Dimebon On The Pharmacokinetics Of Dextromethorphan
- A Phase 1 Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF-01913539] In Japanese And Western Healthy Subjects
- A Phase 1, Non-Randomized, Open-Label, Single-Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF 01913539] In Subjects With Severely-Impaired And Normal Renal Function
- A Phase 1, Randomized, Open-Label, Two-Way Crossover Study To Evaluate The Steady-State Effect Of Dimebon (PF 01913539) On The Single-Dose Pharmacokinetics And Pharmacodynamics Of Warfarin In Healthy Subjects
- A Phase 2, to Evaluating the Safety and Efficacy of Pridopidine Vs Placebo for Symptomatic Treatment in Patients With Huntington's Disease
- A Phase I Clinical Study of ER2001 Injection for the Treatment of Early Manifest Huntington's Disease.
- A Phase I Study To Estimate The Effect Of Ketoconazole And Omeprazole On The Pharmacokinetics Of Dimebon In Healthy Subjects Who Are Normal Or Poor CYP2D6 Metabolizers
- A Phase II Safety and Tolerability Study With SEN0014196
- A Pilot Evaluation of Mindfulness-based Cognitive Therapy for People With Huntington's Disease
Approved drugs (2)
- Deutetrabenazine
- Tetrabenazine
Drugs in development (50)
- Acetylcysteine Phase 2
- ANX-005 Phase 2
- Bevantolol hydrochloride Phase 2
- Biotin Phase 2
- Branaplam Phase 2
- Branaplam hydrochloride Phase 1
- Bupropion Phase 2
- Cannabidiol Phase 2
- Cannabinol Phase 2
- Creatine Phase 3
- Dalzanemdor Phase 3
- Divalproex sodium Phase 2
- Epigalocatechin gallate Phase 2
- Fenofibrate Phase 2
- GSK-356278 Phase 1
- Haloperidol Phase 1
- Idebenone Phase 1
- Laquinimod Phase 2
- Latrepirdine Phase 3
- Lexanersen Phase 1
Other linked drugs (5)
- Atomoxetine hydrochloride
- Cysteamine bitartrate
- Guanfacine hydrochloride
- Lisdexamfetamine dimesylate
- Methylphenidate hydrochloride