Gastrointestinal stromal tumor
Therapeutic area
Gastroenterology
Rare disease
Yes
- Definition
- Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal (GI) tract, typically presenting in adults over the age of 40 (mean age 63), and only rarely in children, in various regions of the GI tract, most commonly the stomach or small intestine but also less commonly in the esophagus, appendix, rectum and colon. GISTs can be asymptomatic or present with various non-specific signs, depending on the location and size of tumor, such as loss of appetite, anemia, weight loss, fatigue, abdominal discomfort or fullness, nausea, vomiting, as well as an abdominal mass, blood in stool, and intestinal obstruction. GISTs can also be seen in familial syndromes such as Carney triad and neurofibromatosis type 1.
- Genetic basis
- Yes
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Gastrointestinal stromal tumor
- Therapeutic area
- Gastroenterology
- gastrointestinal stromal tumor
- GIST
- Gastrointestinal Stromal Tumors
- gastrointestinal stromal neoplasm
- gastrointestinal stromal sarcoma
- gastrointestinal stromal tumor
- gastrointestinal stromal tumor (gist)
- gastrointestinal stromal tumor, familial, isolated cases
- gastrointestinal stromal tumor, isolated cases
- gastrointestinal stromal tumour (gist)
- gist
- gastrointestinal stromal tumors
- gastrointestinal stromal tumours
- Severity
- Severe
- Genetic
- Hereditary
- Gastroenterology
- Oncology
- MONDO ID
- MONDO:0011719
- Parent condition
- MONDO:0003847
Related records
Broader conditions (16)
- Cancer or benign tumor
- Digestive system disorder
- Digestive system neoplasm
- Disease
- Disease by body system or component
- Disease by etiologic mechanism
- Disease of genetic or genomic mechanism
- Hereditary disease
- Human disease
- Intestinal disorder
- Intestinal neoplasm
- Mesenchymal tumor of small intestine
- Neoplasm
- Neoplastic disease or syndrome
- Small intestine disorder
- Small intestine neoplasm
Trials (377)
- (NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors
- (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors
- (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST
- 11C-Acetate PET/CT Non-FDG-Avid Tumors
- 5 Years of Adjuvant Imatinib in Patients With Gastrointestinal Stromal Tumor With a High Risk
- 68Ga-NOTA-RM26 PET/CT for the Detection of Gastrointestinal Stromal Tumor
- 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)
- A Bioequivalence Study of Sunitinib Malate Capsules.
- A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST
- A Clinical Trial to Compare the Pharmacokinetics of Imatinib Mesylate Tablet 400mg (1 Tablet) and Glivec Film-coated Tablet 100mg (4 Tablets)(Phase I)
- A Clinical Trial With a New Needle Device Comparing Two Needles for EUS_FNA of Solid Lesions.
- A Cohort Study on the Safety of Laparoscopic Resection of 5cm or Larger Gastric Gastrointestinal Stromal Tumors
- A Combination Clinical Study of PLX3397 and Pembrolizumab To Treat Advanced Melanoma and Other Solid Tumors
- A Comprehensive, Multinational GIST Registry
- A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study.
- A Drug-drug Interaction Study of Avapritinib and Midazolam
- A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients with Advanced GIST
- A Master Protocol to Evaluate DCC-3009 in Gastrointestinal Stromal Tumor (GIST)
- A Multicenter Study of Avapritinib Efficacy and Safety of Metastatic or Unresectable Gastrointestinal Stromal Tumors
- A Novel Two-Tooth Clip for ESD and EFTR of GIST
Approved drugs (5)
- Avapritinib
- Imatinib mesylate
- Ripretinib
- Sunitinib
- Sunitinib malate
Drugs in development (64)
- Alpelisib Phase 1
- Amcasertib Phase 2
- Atezolizumab Phase 2
- Axitinib Phase 2
- Bevacizumab Phase 3
- Bezuclastinib Phase 1
- BIIB021 Phase 2
- Binimetinib Phase 1
- Buparlisib Phase 1
- Cabozantinib Phase 2
- Carboplatin Phase 2
- Catequentinib Phase 2
- Cisplatin Phase 2
- Crenolanib Phase 3
- Crenolanib besylate Phase 2
- Dasatinib anhydrous Phase 2
- Docetaxel Phase 2
- Dovitinib Phase 2
- Entacapone Early phase 1
- Epacadostat Phase 2
Other linked drugs (3)
- Dasatinib
- Lenvatinib
- Tyrosine