Cerebellar ataxia
Therapeutic area
Neurology
Rare disease
Yes
- Definition
- A neurological syndrome characterized by clumsy and uncoordinated movement of the limbs, trunk, and cranial muscles. It results from pathology in the cerebellum and its connections, or in the proprioceptive sensory pathways.
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Cerebellar ataxia
- Therapeutic area
- Neurology
- cerebellar ataxia
- ataxia syndrome
- cerebellar ataxias
- spinocerebellar ataxia
- spinocerebellar degeneration
- ataxia
- ataxia, cerebellar
- ataxias, cerebellar
- cerebellar dysmetria
- cerebellar dysmetrias
- All therapeutic areas
- Neurology
Sources for recorded values
- Severity
- Severe
- MONDO ID
- MONDO:0000437
- Parent condition
- MONDO:0005395
Related records
Broader conditions (11)
- Atactic disorder
- Brain disorder
- Central nervous system disorder
- Cerebellar degeneration
- Cerebellar disorder
- Disease
- Disease by body system or component
- Human disease
- Movement disorder
- Nervous system disorder
- Neurodegenerative disease
Narrower conditions (171)
- Abetalipoproteinemia
- Acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndrome
- Ataxia - deafness - intellectual disability syndrome
- Ataxia - oculomotor apraxia type 4
- Ataxia telangiectasia
- Ataxia with oculomotor apraxia type 3
- Ataxia-pancytopenia syndrome
- Ataxia-telangiectasia with generalized skin pigmentation and early death
- Autosomal dominant cerebellar ataxia
- Autosomal dominant cerebellar ataxia type I
- Autosomal dominant cerebellar ataxia type III
- Autosomal dominant cerebellar ataxia type IV
- Autosomal dominant cerebellar ataxia, deafness and narcolepsy
- Autosomal recessive ataxia due to PEX10 deficiency
- Autosomal recessive ataxia due to ubiquinone deficiency
- Autosomal recessive ataxia, Beauce type
- Autosomal recessive cerebellar ataxia
- Autosomal recessive cerebellar ataxia - epilepsy - intellectual disability syndrome
- Autosomal recessive cerebellar ataxia - pyramidal signs - nystagmus - oculomotor apraxia syndrome
- Autosomal recessive cerebellar ataxia with late-onset spasticity
Trials (180)
- A 24-week Open-label Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
- A Confirmatory Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
- A Long-Term Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
- A New Method to Treat Hereditary Cerebellar Ataxia - Umbilical Cord Mesenchymal Stem Cells Transplantation
- A Phase 2 Study of NIR178 in Combination With PDR001 in Patients With Solid Tumors and Non-Hodgkin Lymphoma
- A Phase II Double Blind Comparative Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
- A Phase II Study of Sintilimab Combined With Ipilimumab N01, Cetuximab and Dabrafenib in Patients With Microsatellite-Stable, BRAF V600E-Mutated Metastatic Colorectal Cancer
- A Registered Cohort Study on Cerebellar Ataxia in the Organization in South-East China for Cerebellar Ataxia Research (OSCCAR)
- A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD
- A Safety, Pharmacokinetic and Pharmacodynamic Study of Kevetrin in Patients With Advanced Solid Tumors
- A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid Tumors
- A Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
- A Study of Nivolumab-relatlimab Fixed-dose Combination Versus Regorafenib or TAS-102 in Participants With Later-lines of Metastatic Colorectal Cancer
- A Study on Cerebello-Spinal tPCS in Ataxia
- A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors
- A TAK-831-1001, Single and Multiple Rising Dose Study in Healthy Participants
- Aerobic Exercise, Balance Training, and Ataxia
- An Additional Confirmatory Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
- An Extension Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
- An Open-label Trial of Intravenous Immune Globulin (IVIG)in Treating Spinocerebellar Ataxias
Drugs in development (14)
- 2-hydroxypropyl-beta-cyclodextrin Phase 1
- Acetazolamide Phase 2
- Acetylleucine Phase 3
- Dalfampridine Phase 3
- Human immunoglobulin G Phase 2
- Nilotinib Phase 2
- Riluzole Phase 2
- Rimtuzalcap Phase 1
- Rituximab Phase 2
- Rovatirelin Phase 3
- Trehalose Phase 2
- Troriluzole Phase 3
- Troriluzole hydrochloride Phase 3
- Ubidecarenone Phase 1