Acute leukemia
Therapeutic area
Hematology
Rare disease
No
- Definition
- A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- No
- Listing at source
- Listed
- Condition name
- Acute leukemia
- Therapeutic area
- Hematology
- acute leukemia
- acute leukaemia (disease)
- acute leukemia
- acute leukemia (disease)
- stem cell leukaemia
- stem cell leukaemia (disease)
- stem cell leukemia (disease)
- Severity
- Severe
- Hematology
- Oncology
- MONDO ID
- MONDO:0010643
- Parent condition
- MONDO:0005059
Related records
Broader conditions (12)
- Acute disease
- Cancer or benign tumor
- Disease
- Disease by body system or component
- Disease by etiologic mechanism
- Hematologic disorder
- Hematopoietic and lymphoid cell neoplasm
- Hematopoietic and lymphoid system neoplasm
- Human disease
- Leukemia
- Neoplasm
- Neoplastic disease or syndrome
Narrower conditions (159)
- Acute basophilic leukemia
- Acute biphenotypic leukemia
- Acute erythroid leukemia
- Acute leukemia of ambiguous lineage
- Acute lymphoblastic leukemia
- Acute megakaryoblastic leukemia
- Acute megakaryoblastic leukemia in adult
- Acute megakaryoblastic leukemia in down syndrome
- Acute megakaryoblastic leukemia without down syndrome
- Acute monocytic leukemia
- Acute myeloblastic leukemia with maturation
- Acute myeloblastic leukemia without maturation
- Acute myeloid leukemia
- Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent
- Acute myeloid leukemia and myelodysplastic syndromes related to radiation
- Acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor
- Acute myeloid leukemia by FAB classification
- Acute myeloid leukemia with 11q23 abnormalities
- Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)
- Acute myeloid leukemia with BCR-ABL1
Trials (252)
- A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies
- A High Intensity Electronic Health Intervention for the Reduction of Learning Disparities in Childhood Cancer Survivors
- A Phase 1 Trial of TST of PD 0332991 Followed by Cytarabine and Mitoxantrone for Adults With Relapsed and Refractory Acute Leukemias and High-Risk Myelodysplasia
- A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)
- A Phase I Study Investigating the Combination of Cladribine, Low Dose Cytarabine and Sorafenib Alternating With Decitabine in Pediatric Relapsed and Refractory Acute Leukemias
- A Phase I Study Investigating the Combination of the Ziftomenib, Venetoclax and Azacitidine in Pediatric Relapsed and Refractory Acute Leukemias
- A Phase I Study of Hyper-CVAD In Combination With Venetoclax In Pediatric Patients With Relapsed or Refractory Acute Leukemias That Are of the Lymphoid Lineage Including Bi-Phenotypic or Undifferentiated Leukemias
- A Phase I Trial of ZIO-101 in Hematologic Cancers
- A Phase II Study on Allogeneic Stem Cell Transplantation in Patients With Active Acute Leukemia
- A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation
- A Real-world Study on the Efficacy and Safety of Menin Inhibitors as Maintenance After Allo-HSCT
- A Retrospective Study on the Relationship Between Donor Leukocyte Telomere Length and Prognosis of Acute Leukemia Patients Treated With Allogeneic Hematopoietic Stem Cell Transplantation
- A Safety and Efficacy Study of Eltrombopag in Subjects With AML
- A Study for Patients With Acute Leukemia
- A Study of BN104 in the Treatment of Acute Leukemia
- A Study of ONO-7475 in Patients With Acute Leukemias
- A Study of PTX-200 (Triciribine) Plus Cytarabine in Refractory or Relapsed Acute Leukemia
- A Study of Revumenib and Mezigdomide in People With Leukemia
- A Study of Withdrawal of Immunosuppression and Donor Lymphocyte Infusions Following Allogeneic Transplant for Pediatric Hematologic Malignancies
- A Study Testing an Improved Dose of UM171 to Help Make Cord Blood Transplants More Effective and Safe.
Drugs in development (2)
- Revumenib Phase 1
- Rifaximin Phase 2
Other linked drugs (2)
- Bevacizumab
- Crisantaspase