Amyotrophic lateral sclerosis
Therapeutic area
Neurology
Rare disease
Yes
- Definition
- Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord.
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Amyotrophic lateral sclerosis
- Therapeutic area
- Neurology
- amyotrophic lateral sclerosis
- ALS
- Charcot disease
- Lou Gehrig disease
- amyotrophic lateral sclerosis
- All therapeutic areas
- Neurology
- Severity
- Terminal
- MONDO ID
- MONDO:0004976
- Parent condition
- MONDO:0003182
Related records
Broader conditions (10)
- Anterior horn disorder
- Central nervous system disorder
- Disease
- Disease by body system or component
- Human disease
- Motor neuron disorder
- Nervous system disorder
- Neurodegenerative disease
- Neuromuscular disease
- Spinal cord disorder
Narrower conditions (38)
- Adult progressive spinal muscular atrophy, Aran Duchenne type
- Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia
- Amyotrophic lateral sclerosis 27, juvenile
- Amyotrophic lateral sclerosis 28
- Amyotrophic lateral sclerosis type 1
- Amyotrophic lateral sclerosis type 10
- Amyotrophic lateral sclerosis type 11
- Amyotrophic lateral sclerosis type 12
- Amyotrophic lateral sclerosis type 15
- Amyotrophic lateral sclerosis type 16
- Amyotrophic lateral sclerosis type 18
- Amyotrophic lateral sclerosis type 19
- Amyotrophic lateral sclerosis type 2, juvenile
- Amyotrophic lateral sclerosis type 20
- Amyotrophic lateral sclerosis type 21
- Amyotrophic lateral sclerosis type 22
- Amyotrophic lateral sclerosis type 23
- Amyotrophic lateral sclerosis type 3
- Amyotrophic lateral sclerosis type 4
- Amyotrophic lateral sclerosis type 5
Trials (1,009)
- "New Perspectives of Adaptation to NIV in ALS"
- [18F]ACI-19626 PET in TDP-43 Proteinopathies
- [BrainConnexion] - Neurodevice Phase I Trial
- 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Amyotrophic Lateral Sclerosis (REPAIR-ALS)
- 3K3A-APC for Treatment of Amyotrophic Lateral Sclerosis (ALS)
- A 12-week, Multicenter, Safety and Dose-ranging Study of 3 Oral Doses of TCH346 in Patients With Amyotrophic Lateral Sclerosis
- A 6-Month Extension Study to Assess the Long-Term Safety of Engensis in Amyotrophic Lateral Sclerosis
- A Biomarker Study to Evaluate MN-166 in Subjects With Amyotrophic Literal Sclerosis (ALS)
- A Biospecimen and Clinical Data Study on Patients for Drug & Biomarker Discovery
- A Clinical Demonstration of EEG Brain-computer Interface for ALS Patients
- A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)
- A Clinical Trial of Pimozide in Patients With Amyotrophic Lateral Sclerosis (ALS)
- A Clinical Trial of Safety and Efficacy of Fasudil in Subjects With Amyotrophic Lateral Sclerosis (ALS)
- A Clinical Trial to Evaluate NB-4746 in Participants With Amyotrophic Lateral Sclerosis.
- A Clinical Trial to Evaluate the Safety and Efficacy of Fycompa in Subjects With Amyotrophic Lateral Sclerosis (ALS)
- A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS)
- A Compassionate Use Protocol of AMX0035 for Treatment of Patients With Amyotrophic Lateral Sclerosis (ALS)
- A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotrophic Lateral Sclerosis
- A Double-blind Randomised, Placebo-controlled Clinical Trial to Test Ambroxol Treatment in ALS
- A First in Human Study of ORT247 in Healthy Volunteers
Approved drugs (3)
- Edaravone
- Riluzole
- Tofersen
Drugs in development (147)
- Abatacept Phase 1
- Acetylcarnitine Phase 2
- Acetylcysteine zidrimer Phase 1
- Albumin human Phase 2
- Aldesleukin Phase 2
- Amantadine hydrochloride Phase 2
- Ambroxol Phase 2
- Anakinra Phase 2
- ANX-005 Phase 2
- ARGX-119 Phase 2
- Arimoclomol Phase 3
- Arundic acid Phase 2
- Atropine Phase 2
- Atsm copper (II) Phase 2
- Basiliximab Phase 2
- Biotin Phase 2
- Bosutinib Phase 1
- Caffeine Phase 1
- Cannabidiol Phase 3
- Cannabinol Phase 2
Other linked drugs (5)
- Arhalofenate
- Evetifator
- Nerve growth factor
- Psilocybin
- Tofacitinib