Zimberelimab
Highest phase reached
Phase 3
Drug type
Antibody
- Listing at source
- Listed
- Highest phase reached
- Phase 3
- Drug type
- Antibody
- Drug name
- Zimberelimab
- ab 122
- Ab-122
- AB-122
- ab122
- Ab122
- AB122
- anti pd 1 monoclonal antibody gls 010
- ANTI-PD-1 MONOCLONAL ANTIBODY GLS-010
- gls 010
- Gls-010
- GLS-010
- immunoglobulin g4 231 proline anti human programmed cell death protein 1 human monoclonal ab122 gamma 4 chain disulfide with human monoclonal ab122 lambda chain dimer
- immunoglobulin g4 lambda anti homo sapiens programmed cell death protein 1 hpd 1 cd279 antigen homo sapiens monoclonal antibody gamma 4 heavy chain homo sapiens 1 450 vh homo sapiens ighv4 39 01 88 ighd ighj4 01 10 7 15 1 123 homo sapiens ighg4 01 hinge s10 p 231 124 450 137 215 disulfide with lambda light chain homo sapiens 1 216 v lambda homo sapiens iglv2 14 03 96 iglj3 02 9 3 10 1 110 homo sapiens iglc2 01 111 216 dimer 229 229 232 232 bisdisulfide produced in cho k1 cell line glycoform alfa post translational modifications k 450 and k 450 deleted n 300 and n 300 glycosylated
- IMMUNOGLOBULIN G4-LAMBDA, ANTI-(HOMO SAPIENS PROGRAMMED CELL DEATH PROTEIN 1 (HPD-1, CD279-ANTIGEN)); HOMO SAPIENS MONOCLONAL ANTIBODY; .GAMMA.4 HEAVY CHAIN HOMO SAPIENS (1-450) (VH (HOMO SAPIENS IGHV4-39*01 (88%) (IGHD)-IGHJ4*01) (10.7.15) (1-123)-HOMO SAPIENS IGHG4*01 (HINGE(S10>P(231))) (124-450)) (137-215')-DISULFIDE WITH .LAMBDA. LIGHT CHAIN HOMO SAPIENS (1'-216') (V-LAMBDA (HOMO SAPIENS IGLV2-14*03 (96%) IGLJ3*02)(9.3.10) (1'-110')-HOMO SAPIENS IGLC2*01 (111'-216')), DIMER (229-229'':232-232'')-BISDISULFIDE, PRODUCED IN CHO-K1 CELL LINE, GLYCOFORM ALFA. POST-TRANSLATIONAL MODIFICATIONS: K(450) AND K(450'') DELETED, N(300) AND N(300'') GLYCOSYLATED
- IMMUNOGLOBULIN G4(231-PROLINE), ANTI-(HUMAN PROGRAMMED CELL DEATH PROTEIN 1) (HUMAN MONOCLONAL AB122 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL AB122 .LAMBDA.-CHAIN, DIMER
- wbp 3055
- WBP-3055
- wbp3055
- WBP3055
- zimberelimab
- Zimberelimab
- ZIMBERELIMAB
- Zimberelimab (AB122)
- Zimberelimab (GLS-010)
- Zimberelimab (ZIM)
And 7 more, listed on the interactive page.
- CAS registry numbers
- 2259860-24-5
- ChEMBL ID
- CHEMBL4297856
- FDA ingredient codes (UNII)
- ZBL7O904IL
- First in class
- No
- Orphan designation
- No
- Pharmacology name
- zimberelimab
- Type
- Antibody
- Drug name stem
- -mab
- Approval recorded by Guide to Pharmacology
- Yes
- Action
- Binding
- Action type
- Binding
- Target
- programmed cell death 1 (CD279)
- Gene symbol
- PDCD1
- Protein identifier
- Q15116
- Median affinity
- 10.76
- Affinity units
- pKd
- Mechanism
- Programmed cell death protein 1 inhibitor
- Action type
- Inhibitor
- Target
- Programmed cell death protein 1
- Protein identifier
- Q15116
Open Targets mechanisms
- Mechanism
- Programmed cell death protein 1 inhibitor
- Action type
- Inhibitor
- Target
- Programmed cell death protein 1
- Condition
- Carcinoma, Squamous Cell
- Highest recorded phase
- 2
- Condition identifier
- EFO:0000181
- Subject identifier
- D002294
- Condition
- Prostatic Neoplasms
- Highest recorded phase
- 2
- Condition identifier
- EFO:0000196
- Subject identifier
- D011471
- Condition
- Adenocarcinoma
- Highest recorded phase
- 3
- Condition identifier
- EFO:0000228
- Subject identifier
- D000230
- Condition
- Adenocarcinoma, Clear Cell
- Highest recorded phase
- 1
- Condition identifier
- EFO:0000348
- Subject identifier
- D018262
- Condition
- Glioblastoma
- Highest recorded phase
- 0.5
- Condition identifier
- EFO:0000519
- Subject identifier
- D005909
- Condition
- Neoplasms
- Highest recorded phase
- 2
- Condition identifier
- EFO:0000616
- Subject identifier
- D009369
- Condition
- Prostatic Neoplasms
- Highest recorded phase
- 2
- Condition identifier
- EFO:0000673
- Subject identifier
- D011471
- Condition
- Melanoma
- Highest recorded phase
- 2
- Condition identifier
- EFO:0000756
- Subject identifier
- D008545
- Condition
- Uterine Cervical Neoplasms
- Highest recorded phase
- 3
- Condition identifier
- EFO:0001061
- Subject identifier
- D002583
- Condition
- Pancreatic Neoplasms
- Highest recorded phase
- 2
- Condition identifier
- EFO:0002618
- Subject identifier
- D010190
- Condition
- Carcinoma, Non-Small-Cell Lung
- Highest recorded phase
- 3
- Condition identifier
- EFO:0003060
- Subject identifier
- D002289
- Condition
- Cholangiocarcinoma
- Highest recorded phase
- 2
- Condition identifier
- EFO:0005221
- Subject identifier
- D018281
- Condition
- Pancreatic Neoplasms
- Highest recorded phase
- 2
- Condition identifier
- EFO:1000359
- Subject identifier
- D010190
- Condition
- Rectal Neoplasms
- Highest recorded phase
- 2
- Condition identifier
- EFO:1000657
- Subject identifier
- D012004
- Condition
- Uterine Cervical Neoplasms
- Highest recorded phase
- 3
- Condition identifier
- MONDO:0002974
- Subject identifier
- D002583
- Condition
- Urinary Bladder Neoplasms
- Highest recorded phase
- 2
- Condition identifier
- MONDO:0004986
- Subject identifier
- D001749
- Condition
- Neoplasms
- Highest recorded phase
- 2
- Condition identifier
- MONDO:0004992
- Subject identifier
- D009369
- Condition
- Carcinoma, Pancreatic Ductal
- Highest recorded phase
- 2
- Condition identifier
- MONDO:0005184
- Subject identifier
- D021441
- Condition
- Carcinoma, Non-Small-Cell Lung
- Highest recorded phase
- 3
- Condition identifier
- MONDO:0005233
- Subject identifier
- D002289
- Condition
- Breast Neoplasms
- Highest recorded phase
- 2
- Condition identifier
- MONDO:0007254
- Subject identifier
- D001943
- Condition
- Prostatic Neoplasms, Castration-Resistant
- Highest recorded phase
- 2
- Condition identifier
- MONDO:0008315
- Subject identifier
- D064129
- Condition
- Hodgkin Disease
- Highest recorded phase
- 3
- Condition identifier
- MONDO:0009348
- Subject identifier
- D006689
- Condition identifier
- EFO_0000196
- Highest recorded phase
- 2
- Condition identifier
- EFO_0000228
- Highest recorded phase
- 3
- Condition identifier
- EFO_0000348
- Condition identifier
- EFO_0000519
- Condition identifier
- EFO_0000616
- Condition identifier
- EFO_0000756
- Highest recorded phase
- 2
- Condition identifier
- EFO_0003060
- Highest recorded phase
- 3
- Condition identifier
- EFO_1000359
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0000386
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0001056
- Highest recorded phase
- 1
- Condition identifier
- MONDO_0001402
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0001528
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0002120
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0002974
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0003060
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0003219
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0004952
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0004986
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0004992
- Condition identifier
- MONDO_0004992
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0005004
- Highest recorded phase
- 1
- Condition identifier
- MONDO_0005005
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0005028
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0005036
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0005070
- Highest recorded phase
- 1
And 25 more, listed on the interactive page.
- Event
- chemotherapy toxicity attenuation
- Reports
- 1
- Reporting signal score
- 9.06841
- Event
- cortisol abnormal
- Reports
- 1
- Reporting signal score
- 8.00378
- Event
- dysphagia
- Reports
- 5
- Reporting signal score
- 13.8607
- Event
- platelet count decreased
- Reports
- 4
- Reporting signal score
- 9.25917
- Event
- respiratory tract infection
- Reports
- 3
- Reporting signal score
- 10.2566
- Event
- vomiting
- Reports
- 6
- Reporting signal score
- 9.06953
- NCT03547973
- NCT05329766
- NCT06120075
- NCT03628677
- NCT03713905
- NCT04087018
- NCT05007782
- NCT05840224
- NCT05909436
- NCT06082960
- NCT03655483
- NCT05518318
- NCT05900765
- NCT03972722
- NCT05437692
- NCT05798819
- NCT05872724
- NCT06055738
- NCT06128460
- NCT06155396
- NCT04104672
- NCT06009029
- NCT04262856
- NCT04791839
- NCT05502237
And 20 more, listed on the interactive page.
- Prodrug
- No
- Chirality
- Single enantiomer
- Inorganic
- No
- Natural product
- No
- Component
- Glycosylation sites (N)
- Sequence
- Asn-300 $ Asn-300''''
- Component
- Heavy chain
- Type
- Protein
- Sequence
- QLQLQESGPGLVKPSETLTLTCTVSADSISSTTYYWVWIRQPPGKGLEWIGSISYSGSTYYNPSLKSRVTVSVDTSKNQFSLKLNSVAATDTALYYCARHLGYNGRYLPFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
- Component
- Light chain
- Type
- Protein
- Sequence
- QSALTQPASVSGSPGQSITISCTGTSSDVGFYNYVSWYQQHPGKAPELMIYDVSNRPSGVSDRFSGSKSGNTASLTISGLQAEDEADYYCSSYTSISTWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
- Component
- Disulfide bridges
- Sequence
- 22'-90' $ 22'''-90''' $ 22-97 $ 22''-97'' $ 137-215' $ 137''-215''' $ 138'-197' $ 138'''-197''' $ 150-206 $ 150''-206'' $ 229-229'' $ 232-232'' $ 264-324 $ 264''-324'' $ 370-428 $ 370''-428''
- Component
- Glycosylation sites (N)
- Sequence
- Asn-300 $ Asn-300''
Related records
Trials (70)
- A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body
- A Clinical Trial to Assess COM503 in Participants With Advanced Solid Malignancies
- A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors
- A Phase 2 Study to Evaluate the Triplet Combination of Pemetrexed Plus AB928 (Etrumadenant) + AB122 (Zimberelimab) in Patients With Previously Treated Advanced or Metastatic MTAP Deficient Urothelial Carcinoma
- A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer.
- A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies
- A Study of Concurrent Chemoradiation in Combination With or Without PD1 Inhibitor AB122 Adenosine 2a Receptor / Adenosine 2b Receptor Inhibitor AB928 Therapies in Locally Advanced Head and Neck Cancers
- A Study of Etrumadenant and Zimberelimab in People With Dedifferentiated Liposarcoma
- A Study of GLS-010 Plus Platinum-containing Chemotherapy±Bevacizumab as First-line Treatment for Persistent, Recurrent, or Metastatic Cervical Cancer
- A Study of RC48-ADC Combination With Zimberelimab Injection Therapies at Least First-line Platinum-containing Standard Therapy Failed With Recurrent or Metastatic Cervical Cancer
- A Study of Zimberelimab(GLS-010) Combined With AVD for Newly Diagnosed Early-stage Hodgkin's Lymphoma
- A Study to Evaluate AB308 in Combination With AB122 in Participants With Advanced Malignancies
- A Study to Evaluate Immunotherapy Combinations in Participants With Lung Cancer
- A Study to Evaluate the Safety and Tolerability of AB154 in Participants With Advanced Malignancies
- A Study to Evaluate the Safety and Tolerability of AB680 in Participants With Gastrointestinal Malignancies
- A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies
- AB122 Platform Study
- AB154 Combined With AB122 for Recurrent Glioblastoma
- AB801 in Combination With Chemotherapy and Immunotherapy for the Treatment of Patients With Borderline Resectable, Locally Advanced or Metastatic Cholangiocarcinoma or Pancreatic Cancer
- Adenosine Receptor Antagonist Combination Therapy for Metastatic Castrate Resistant Prostate Cancer
In development for (21)
- Adenocarcinoma Phase 3
- Breast cancer Phase 2
- Cancer Phase 2
- Cervical cancer Phase 3
- Cervical carcinoma Phase 3
- Cholangiocarcinoma Phase 2
- Classic Hodgkin lymphoma Phase 3
- Clear cell adenocarcinoma Phase 1
- Exocrine pancreatic carcinoma Phase 2
- Glioblastoma Early phase 1
- Head and neck squamous cell carcinoma Phase 2
- Malignant pancreatic neoplasm Phase 2
- Melanoma Phase 2
- Metastatic prostate carcinoma Phase 2
- Neoplasm Phase 2
- Non-small cell lung carcinoma Phase 3
- Pancreatic ductal adenocarcinoma Phase 2
- Prostate adenocarcinoma Phase 2
- Prostate cancer Phase 2
- Rectal cancer Phase 2
Targets (1)
- PDCD1 Programmed cell death protein 1 inhibitor