Telisotuzumab adizutecan
Highest phase reached
Phase 2
Drug type
Antibody
- Listing at source
- Listed
- Highest phase reached
- Phase 2
- Drug type
- Antibody
- Drug name
- Telisotuzumab adizutecan
- immunoglobulin g1 anti human hepatocyte growth factor receptor human mus musculus monoclonal abt 700 heavy chain disulfide with human mus musculus monoclonal abt 700 κ chain dimer reduced hexakis thioether with n 2 mercaptoacetyl l valyl n 3 7s 7 ethyl 7 8 11 13 tetrahydro 7 hydroxy 8 11 dioxo 10h 1 3 dioxolo 4 5 g pyrano 3 4 6 7 indolizino 1 2 b quinolin 14 yl bicyclo 1 1 1 pent 1 yl l alaninamide
- immunoglobulin g1 kappa anti homo sapiens met met proto oncogene hepatocyte growth factor hgf receptor hgfr scatter factor sf receptor hgf sf receptor receptor tyrosine protein kinase c met papillary renal cell carcinoma 2 rccp2 humanized monoclonal antibody conjugated on an average of 6 cysteinyl residues to adizutecan comprising a linker and a camptothecin derivative h gamma1 heavy chain humanized 1 445 vh homo sapiens ighv1 2 02 92 9 ighd ighj4 01 100 cdr imgt 8 8 11 26 33 51 58 97 107 1 118 homo sapiens ighg1 03 g1m3 ng1m1 ch1 r120 ch3 e12 m14 ch1 r120 215 119 216 hinge 1 15 k7 del t8 c 223 t10 del 217 229 ch2 230 339 ch3 e12 355 m14 357 340 444 chs k2 del 445 119 445 221 218 disulfide with l kappa light chain humanized 1 218 v kappa homo sapiens igkv4 1 01 85 1 igkj4 01 100 cdr imgt 10 3 9 27 36 54 56 93 101 1 111 homo sapiens igkc 01 100 km3 a45 1 157 v101 195 112 218 dimer 223 223 225 225 228 228 trisdisulfide produced in a cell line from chinese hamster ovary cho cells derived from the cell line cho k1sv expressing the enzyme glutamine synthetase gs glycoform alfa substituted at the sulfur atoms of an average of 6 l cysteinyl residues among 221 223 225 228 218 221 223 225 228 and 218 with radical group 2 2s 1 2s 1 3 7s 7 ethyl 7 hydroxy 14 methyl 8 11 dioxo 7 8 11 13 tetrahydro 2h 10h 1 3 dioxolo 4 5 g pyrano 3 4 6 7 indolizino 1 2 b quinolin 14 yl bicyclo 1 1 1 pentan 1 yl amino 1 oxopropan 2 yl amino 3 methyl 1 oxobutan 2 yl amino 2 oxoethyl adizutecan
- immunoglobulin G1-kappa, anti-[Homo sapiens MET (met proto-oncogene, hepatocyte growth factor (HGF) receptor, HGFR, scatter factor (SF) receptor, HGF/SF receptor, receptor tyrosine-protein kinase c-met, papillary renal cell carcinoma 2, RCCP2)], humanized monoclonal antibody, conjugated on an average of 6 cysteinyl residues to adizutecan, comprising a linker and a camptothecin derivative; H-gamma1 heavy chain humanized (1-445) [VH (Homo sapiens IGHV1-2*02 (92.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (215) (119-216), hinge 1-15 K7>del, T8>C (223), T10>del (217-229), CH2 (230-339), CH3 E12 (355), M14 (357) (340-444), CHS K2>del (445)) (119-445)], (221-218')-disulfide with L-kappa light chain humanized (1'-218') [V-KAPPA (Homo sapiens IGKV4-1*01 (85.1%) -IGKJ4*01 (100%), CDR-IMGT [10.3.9] (27'-36'.54'-56'.93'-101')) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157'), V101 (195') (112'-218')]; dimer (223-223''-225-225'':228-228'')-trisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1SV, expressing the enzyme glutamine synthetase (GS), glycoform alfa; substituted at the sulfur atoms of an average of 6 L-cysteinyl residues among 221, 223, 225, 228, 218', 221'', 223'', 225'', 228'' and 218''' with radical group 2-{[(2S)-1-{[(2S)-1-({3-[(7S)-7-ethyl-7-hydroxy-14-methyl-8,11-dioxo-7,8,11,13-tetrahydro-2H,10H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-14-yl]bicyclo[1.1.1]pentan-1-yl}amino)-1-oxopropan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]amino}-2-oxoethyl (adizutecan)
- Immunoglobulin G1, anti-(human hepatocyte growth factor receptor) (human-Mus musculus monoclonal ABT-700 heavy chain), disulfide with human-Mus musculus monoclonal ABT-700 κ-chain, dimer, reduced, hexakis(thioether) with N-(2-mercaptoacetyl)-L-valyl-N-[3-[(7S)-7-ethyl-7,8,11,13-tetrahydro-7-hydroxy-8,11-dioxo-10H-1,3-dioxolo[4,5-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-14-yl]bicyclo[1.1.1]pent-1-yl]-L-alaninamide
- telisotuzumab adizutecan
- Telisotuzumab adizutecan
- Telisotuzumab Adizutecan
- Telisotuzumab adizutecan [WHO-DD]
- telisotuzumab adizutecan who dd
- CAS registry numbers
- 2850366-99-1
- ChEMBL ID
- CHEMBL6068181
- FDA ingredient codes (UNII)
- CVX52RV2DC
- Patents
- 0
- Designations
- 1
- First in class
- No
- Fast track
- No
- Breakthrough designation
- No
- Orphan designation
- No
- Priority review
- No
- Orphan exclusivity
- No
- Accelerated approval
- No
- Drug name stem
- -mab; -mab; -tecan
Investigated indications
- Condition
- Neoplasms
- Highest recorded phase
- 2
- Condition identifier
- EFO:0000616
- Subject identifier
- D009369
- Condition identifier
- EFO_0000616
- Condition identifier
- EFO_0003060
- Condition identifier
- MONDO_0003060
- Highest recorded phase
- 1
- Condition identifier
- MONDO_0003219
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0005028
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0005036
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0005070
- Condition identifier
- MONDO_0005184
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0005233
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0005494
- Highest recorded phase
- 1
- Condition identifier
- MONDO_0005575
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0005575
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0005580
- Highest recorded phase
- 1
- Condition identifier
- MONDO_0007256
- Highest recorded phase
- 1
- Condition identifier
- MONDO_0010150
- Highest recorded phase
- 1
- Prodrug
- No
- Chirality
- Single enantiomer
- Inorganic
- No
- Natural product
- No
- Component
- Heavy chain
- Type
- Protein
- Sequence
- QVQLVQSGAEVKKPGASVKVSCKASGYIFTAYTMHWVRQAPGQGLEWMGWIKPNNGLANYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARSEITTEFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDCHCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
- Component
- Disulfide bridges
- Sequence
- 22-96 $ 22''-95'' $ 23'-92' $ 23'''-92''' $ 138'-198' $ 138'''-198''' $ 145-201 $ 145''-201'' $ 221-218' $ 221''-218''' $ 223-223'' $ 225-225'' $ 228-228'' $ 260-320 $ 260''-320'' $ 366-424 $ 366''-424''
- Component
- Light chain
- Type
- Protein
- Sequence
- DIVMTQSPDSLAVSLGERATINCKSSESVDSYANSFLHWYQQKPGQPPKLLIYRASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSKEDPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- Component
- Glycosylation sites (N)
- Sequence
- 296 $ 296''
Related records
Trials (15)
- A Study Assessing Adverse Events and Disease Activity of Intravenously (IV) Infused Telisotuzumab Adizutecan in Adult Participants With c-Met Protein Above Cutoff Level Above Refractory Metastatic Colorectal Cancer
- A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer
- A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
- A Study to Assess Adverse Events and Change in Disease Activity in Participants 12 Years of Age or Older With Locally Advanced or Metastatic Solid Tumors That Harbor MET Amplification Receiving Intravenously Infused Telisotuzumab Adizutecan
- A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer
- A Study to Assess Adverse Events and Change in Disease Activity With Treatment Combinations With Telisotuzumab Adizutecan in Adults Participants With Pancreatobiliary Cancers
- A Study to Assess Adverse Events, Change in Disease Activity and Optimal Dose of Intravenous (IV) Telisotuzumab Adizutecan With IV Pembrolizumab for First-Line Treatment of Adult Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
- A Study to Assess Adverse Events, Change in Disease Activity of Intravenous Telisotuzumab Adizutecan in Combination With Osimertinib as First-Line Treatment in Adult Participants With Locally Advanced Unresectable or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer
- A Study to Assess Intravenous (IV) Telisotuzumab Adizutecan in Combination With Fluorouracil, Folinic Acid, and Oxaliplatin (FOLFOX) Compared to Standard of Care in Adult Participants With First-Line Metastatic Pancreatic Ductal Adenocarcinoma
- A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
- A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma
- Expanded Access to Telisotuzumab Adizutecan
- Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Adizutecan (ABBV-400) Moves Through the Body of Adult Participants With Unresectable Locally Advanced/Metastatic Colorectal Cancer
- Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan
- Study to Evaluate Adverse Events and Efficacy of Intravenous (IV) Telisotuzumab Adizutecan in Combination With a PD-1 Immune Checkpoint Inhibitor in Adult Participants With Advanced or Metastatic Non-Squamous NSCLC With No Prior Treatment for Advanced Disease, and No Actionable Genomic Alterations
In development for (2)
- Colorectal cancer Phase 2
- Neoplasm Phase 2