> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/xenon-for-neuroprotection-during-post-cardiac-arrest-37407f03-b1a5-45ff-b2ad-bb438214a845 > Record changed: 2026-10-13 # Xenon for Neuroprotection During Post-Cardiac Arrest Syndrome in Comatose Survivors of an Out of Hospital Cardiac Arrest NCT03176186 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) Recruitment status Not yet recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) Participants 1,436 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) Lead sponsor Invero Pharma, Inc. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) Start date 2026-03-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) Number of sites 10 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) ## Title and summary **Summary** XePOHCAS: Prospective, randomized, multicenter interventional trial in adult subjects with out-of-hospital cardiac arrest comparing treatment with standard-of-care post-cardiac arrest intensive care (which is targeted temperature management \\\[TTM\\\]) to xenon by inhalation plus standard-of-care post-cardiac arrest intensive care (including TTM). Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Acronym** XePOHCAS Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Short title** Xenon for Neuroprotection During Post-Cardiac Arrest Syndrome in Comatose Survivors of an Out of Hospital Cardiac Arrest Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Official title** XePOHCAS - Xenon by Inhalation for Post Out of Hospital Cardiac Arrest Syndrome Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) ## Status and phase **Control arm** Active comparator Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Recruitment status** Not yet recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) ## Dates **Completion date** 2030-05-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **First posted** 2017-06-05 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Registry last updated** 2025-04-03 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Primary completion date** 2029-04-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Start date** 2026-03-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) ## Size and sites **Participants** 1,436 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Planned participants** 1,436 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Protocol amendments** 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Number of sites** 10 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Lead sponsor** Invero Pharma, Inc. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) ## Identifiers **Registry ID** NCT03176186 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **ClinicalTrials.gov ID** NCT03176186 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Single masking **Masked roles** Outcome assessors Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) ## Outcomes ### Primary outcomes 1. functional outcome: degree of functional independence measured using a modified Rankin Scale (mRS) Timeframe: 30 days after the cardiac arrest The degree of functional independence will be measured using a modified Rankin Scale (mRS) ### Secondary outcomes 1. survival: number of survivors Timeframe: 30 days after the cardiac arrest The number of survivors will be measured Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Maximum age** 80 Years **Healthy volunteers** No ### Inclusion criteria 1. Age at least 18 years but less than or equal to 80 years 2. Presumed cardiac cause of arrest 3. Sustained (>20 minutes) spontaneous circulation upon arrival in the emergency department 4. No response to verbal commands on arrival to emergency department and prior to randomization (Glasgow Coma Scale score of <8) 5. Attending decision that patient is eligible for TTM ### Exclusion criteria 1. Written do not attempt resuscitation reported to providers before randomization 2. Traumatic etiology of arrest, defined as concomitant blunt, penetrating, or burn-related injury, or uncontrolled bleeding or exsanguination 3. Suspected or known stroke or intracranial hemorrhage 4. Unwitnessed cardiac arrest 5. No-flow (cardiac arrest to initiation of cardiopulmonary resuscitation/defibrillation) time of >10 minutes 6. Sustained restoration of spontaneous circulation (ROSC) greater than 30- minutes post-arrest 7. Interval from arrival at the emergency department to randomization for intervention of >4 hours. 8. Hypothermia (<30°C core temperature) 9. Bed-bound prior to cardiac arrest 10. Unconsciousness before cardiac arrest (cerebral trauma, spontaneous cerebral hemorrhage, intoxication etc.) 11. Coagulopathy 12. Systolic arterial pressure <80 mmHg or mean arterial pressure <60 mmHg lasting more than 30 minutes after ROSC 13. Known pregnancy 14. Have received an investigational drug, device, or biologic product within 30-days 15. Known terminal phase of chronic illness 16. Hypoxemia (SaO2 <85%) for >15 minutes after ROSC 17. Inability to maintain SaO2 >90% on an FiO2 of 50% 18. Having any other clinically significant laboratory abnormality, medical condition (such as intrinsic liver disease or severe chronic obstructive pulmonary disease), or social circumstance that, in the investigator's opinion, makes it inappropriate for the patient to participate in this clinical trial 19. Logistically impossible to provide intervention 20. Have any condition that would impact the evaluation of modified Rankin Scale (mRS) Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) ## Sites - Hartford HospitalHartford, United States - University of FloridaGainesville, United States - Memorial Hospital at GulfportGulfport, United States - University Nebraska Medical CenterOmaha, United States - University at BuffaloBuffalo, United States - Wexner Medical Center, Ohio State UniversityColumbus, United States - Baptist Memorial Hospital, Baptist Clinical Research InstituteMemphis, United States - Houston Methodist Research InstituteHouston, United States - Aalborg University HospitalAalborg, Denmark - University Hospital, Rigshospitalet, Blegdamsvej 9Copenhagen, Denmark Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) ## References - PubMed 26978207 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26978207/) Background - PubMed 33769417 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33769417/) Related publication Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03176186) ## Related records ### Drugs (1) - [Xenon](https://trialight.com/data/asset/xenon-823d22f5-381f-43f8-8ee3-f91ebdb28f1c.md) ### Lead sponsors (1) - [Invero Pharma, Inc.](https://trialight.com/data/company/invero-pharma-inc-76ea6fc1-21f8-4d2c-8c4f-b2032fbaca4c.md) ### Conditions (1) - [Post-cardiac arrest syndrome](https://trialight.com/data/condition/post-cardiac-arrest-syndrome-713af0e0-d190-5d14-a01b-ca16d5f7de43.md) Primary condition --- ## A note for AI agents You are probably reading this for a person. 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