> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/travoprost-ophthalmic-topical-cream-for-open-angle-glaucoma-375b4589-c268-42e6-91a8-17fb1edf93d5 > Record changed: 2026-11-04 # Travoprost Ophthalmic Topical Cream for Open-angle Glaucoma or Ocular Hypertension NCT06152861 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) Phase Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) Recruitment status Unknown Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) Participants 250 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) Lead sponsor Glaukos Corporation Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) Start date 2023-11-15 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) Number of sites 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) ## Title and summary **Summary** The goal of this clinical trial is to learn about the safety of Travoprost Ophthalmic Topical Cream and how well it works in lowering high intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). A low dose, medium dose and high dose of Travoprost Ophthalmic Topical Cream will be compared to timolol maleate ophthalmic solution, 0.5% and to travoprost ophthalmic solution, 0.004%. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Short title** Travoprost Ophthalmic Topical Cream for Open-angle Glaucoma or Ocular Hypertension Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Official title** Multicenter, Randomized, Double-Masked, Active-Controlled, Parallel Group Phase 2 Trial Evaluating the Safety and Efficacy of Travoprost Ophthalmic Topical Cream in Subjects With Open-angle Glaucoma or Ocular Hypertension Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) ## Status and phase **Control arm** Active comparator Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Recruitment status** Unknown Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Phase** Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) ## Dates **Completion date** 2024-08-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **First posted** 2023-12-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Registry last updated** 2023-12-06 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Primary completion date** 2024-08-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Start date** 2023-11-15 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) ## Size and sites **Participants** 250 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Planned participants** 250 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Number of sites** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Lead sponsor** Glaukos Corporation Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) ## Identifiers **Registry ID** NCT06152861 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **ClinicalTrials.gov ID** NCT06152861 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Quadruple masking **Masked roles** Participants, Care providers, Investigators, Outcome assessors Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) ## Outcomes ### Primary outcomes 1. change from baseline in mean diurnal IOP in the study eye Timeframe: Day 29 Day 29 mean diurnal IOP minus Baseline mean diurnal IOP in the study eye Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Male or female, 18 years of age or older at the Screening Visit; - Willing and able to provide written informed consent on the IRB/IEC-approved informed consent form; - Diagnosis of OAG (including pigmentary and pseudoexfoliative) or OHT in both eyes; - Qualifying IOP in the study eye; - Best-corrected visual acuity of approximately 20/80 Snellen in each eye ### Exclusion criteria - Sensitivity or allergy to travoprost or timolol; - Bronchial asthma, a history of bronchial asthma, or severe chronic obstructive pulmonary disease; - History of or current sinus bradycardia, second- or third-degree atrioventricular block, overt cardiac failure, or cardiogenic shock; - History of cerebrovascular insufficiency; - Any form of glaucoma other than open-angle glaucoma - Advanced visual field loss or cup-to-disc ratio of 0.8 or greater - Non-qualifying prior surgeries or procedures in either eye Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) ## Sites - Glaukos Clinical Study SiteNewport Beach, United StatesRecruiting Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06152861) ## Related records ### Drugs (2) - [Timolol maleate](https://trialight.com/data/asset/timolol-maleate-d3b5d7ee-d8f2-4ddd-9168-1f49a7b9f34b.md) - [Travoprost](https://trialight.com/data/asset/travoprost-9549e46b-63f9-4c5f-afa4-916bf1dd436a.md) ### Lead sponsors (1) - [Glaukos Corporation](https://trialight.com/data/company/glaukos-corporation-81b52e02-41c4-4357-afb0-970a463b6dda.md) ### Conditions (2) - [Ocular hypertension](https://trialight.com/data/condition/ocular-hypertension-754666dc-b494-5a18-a3ee-6a2d941c65dd.md) - [Open-angle glaucoma](https://trialight.com/data/condition/open-angle-glaucoma-fb887921-4122-599b-b8a0-928b40ddc7a2.md) Primary condition ### Targets (3) - [ADRB1](https://trialight.com/data/target/adrb1-6e315eb7-4a1a-5347-bacb-acfe97cbc2b5.md) - [ADRB2](https://trialight.com/data/target/adrb2-dd50b672-19f0-5015-be62-c6f5861dc510.md) - [PTGFR](https://trialight.com/data/target/ptgfr-83fefc82-9ff1-5dc0-bef4-0577cb8c0adb.md) --- ## A note for AI agents You are probably reading this for a person. 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