> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/study-to-assess-the-effects-of-angiopoietin-like-protein-3-7440e204-563e-4cf8-aefe-6a79062af0b9 > Record changed: 2026-10-13 # Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease NCT07271186 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) Phase Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) Participants 270 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) Lead sponsor Regeneron Pharmaceuticals Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) Start date 2026-01-09 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) Number of sites 58 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) ## Title and summary **Summary** This study is researching experimental drugs called ALN-ANG3 and evinacumab (called "study drugs"). The study is focused on participants who have diabetic kidney disease. The aim of the study is to see how safe and effective the study drugs are. The study is looking at several other research questions, including: \* What side effects may happen from taking the study drug \* How much study drug is in the blood at different times Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Acronym** ANCHOR-POC Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Short title** Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Official title** A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamic Effects of ANGPTL3 Inhibition With Either Small-Interfering RNA Alone or in Combination With an ANGPTL3 Antibody in Participants With Diabetic Kidney Disease Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Phase** Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) ## Dates **Completion date** 2028-04-07 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **First posted** 2025-12-09 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Registry last updated** 2026-08-10 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Primary completion date** 2027-09-24 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Start date** 2026-01-09 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) ## Size and sites **Participants** 270 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Planned participants** 270 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Number of sites** 58 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Lead sponsor** Regeneron Pharmaceuticals Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) ## Identifiers **Registry ID** NCT07271186 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **ClinicalTrials.gov ID** NCT07271186 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Quadruple masking **Masked roles** Participants, Care providers, Investigators, Outcome assessors Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) ## Outcomes ### Primary outcomes 1. Percent change in Urine Albumin to Creatinine Ratio (UACR) Timeframe: Baseline to Week 24 ### Secondary outcomes 1. Change in Estimated Glomerular Filtration Rate (eGFR) Timeframe: Baseline to Week 24 2. Change in total cholesterol Timeframe: Baseline to Week 24 3. Change in Low-Density Lipoprotein-Cholesterol (LDL-C) Timeframe: Baseline to Week 24 4. Change in High-Density Lipoprotein-Cholesterol (HDL-C) Timeframe: Baseline to Week 24 5. Change in non-High-Density Lipoprotein-Cholesterol (non-HDL-C) Timeframe: Baseline to Week 24 6. Change in triglycerides Timeframe: Baseline to Week 24 7. Change in Apolipoprotein B (ApoB) Timeframe: Baseline to Week 24 8. Concentration of combined ALN-ANG3 and metabolite(s) and evinacumab Timeframe: Up to Week 24 9. Change in concentration of Angiopoietin-Like Protein-3 (ANGPTL-3) Timeframe: Baseline to Week 24 10. Occurrence of Treatment-Emergent Adverse Events (TEAEs) Timeframe: Up to Week 48 11. Severity of TEAEs Timeframe: Up to Week 48 12. Incidence of ADAs to ALN-ANG3 Timeframe: Through Week 24 13. Magnitude of ADAs to ALN-ANG3 Timeframe: Through Week 24 14. Incidence of ADAs to evinacumab Timeframe: Through Week 24 15. Magnitude of ADAs to evinacumab Timeframe: Through Week 24 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Maximum age** 80 Years **Healthy volunteers** No Key Inclusion Criteria: 1. Medical history of type 2 diabetes and receiving medical therapy or lifestyle interventions for glucose management 2. Hemoglobin A1C (HbA1c) of 6.5 to 10% at screening 3. eGFR 30 to 90 mL/min/1.73 m^2 using 2021 Chronic Kidney Disease-Epidemiology Collaboration-Estimated Glomerular Filtration Rate using Creatinine and Cystatin C (CKD-EPI eGFRcr-cys) equation at screening 4. Albuminuria: Urine Albumin to Creatinine Ratio (UACR) of 500 to 5000 mg/g at screening Key Exclusion Criteria: 1. Known medical history or clinical evidence indicative of non-diabetic renal disease 2. Renal disease that required treatment with systemic immunosuppressive therapy, or a history of dialysis or renal transplant 3. Medically unstable as assessed by the investigator 4. Hospitalization (ie, >24 hours) within 30 days of the screening visit NOTE: Other Protocol-Defined Inclusion/Exclusion Criteria Apply Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) ## Sites - Apogee Clinical Research, LLCHuntsville, United StatesRecruiting - Applied Research Center of ArkansasLittle Rock, United StatesRecruiting - AME Clinical ResearchHuntington Beach, United StatesRecruiting - Amicis Research CenterNorthridge, United StatesRecruiting - FOMAT - Vista del Mar Medical GroupOxnard, United StatesRecruiting - Central Coast NephrologySalinas, United StatesRecruiting - North America Research InstituteSan Dimas, United StatesRecruiting - Amicis Research CenterSanta Clarita, United StatesRecruiting - Valiance Clinical ResearchTarzana, United StatesRecruiting - Amicis Research CenterValencia, United StatesRecruiting - National Institute of Clinical Research, Inc.Victorville, United StatesRecruiting - Yale UniversityNew Haven, United StatesRecruiting - D&H Doral Research CenterDoral, United StatesRecruiting - AGA Clinical TrialsHialeah, United StatesRecruiting - Convenient Medical CenterHialeah, United StatesRecruiting - Elixia HollywoodHollywood, United StatesRecruiting - D&H Pompano Research CenterMargate, United StatesRecruiting - LCC Medical Research InstituteMiami, United StatesRecruiting - D&H National Research Centers, IncMiami, United StatesRecruiting - Regenerate Primary Medical Research, LLCMiami, United StatesRecruiting - Ocean Blue Medical Research Center - Internal MedicineMiami Springs, United StatesRecruiting - Innovia Research CenterMiramar, United StatesRecruiting - Central Florida Kidney Specialists OakwaterOrlando, United StatesRecruiting - Bolanos Clinical ResearchPembroke Pines, United StatesRecruiting - Progressive Medical ResearchPort Orange, United StatesRecruiting And 33 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07271186) ## Related records ### Drugs (1) - [Evinacumab](https://trialight.com/data/asset/evinacumab-756ee795-e24e-4f94-87b2-19f7d738fbc8.md) ### Lead sponsors (1) - [Regeneron Pharmaceuticals](https://trialight.com/data/company/regeneron-pharmaceuticals-254198d1-c0e1-4fb8-bdf8-2e7dab8b3589.md) ### Conditions (3) - [Diabetic kidney disease](https://trialight.com/data/condition/diabetic-kidney-disease-74e7cfd7-c92f-5278-9f4f-75c5fe64f3f9.md) Primary condition - [Kidney failure](https://trialight.com/data/condition/kidney-failure-f26737b4-3a55-50be-b6c3-b76514cb5067.md) - [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) ### Targets (1) - [ANGPTL3](https://trialight.com/data/target/angptl3-28ff9f94-9797-5f15-b225-9e6e1b7b004a.md) --- ## A note for AI agents You are probably reading this for a person. 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