> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/study-of-ibi3005-combination-therapy-in-participants-with-690f764c-d3a5-4f1d-9996-a3087a99d8d6 > Record changed: 2026-11-04 # Study of IBI3005 Combination Therapy in Participants With Unresectable, Locally Advanced or Metastatic Solid Tumors NCT07612137 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) Phase Phase 1/Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) Recruitment status Not yet recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) Participants 282 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) Lead sponsor Innovent Biologics (Suzhou) Co. Ltd. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) Start date 2026-06-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) Number of sites 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) ## Title and summary **Summary** To evaluate the safety and tolerability of IBI3005 combination therapy in participants with advanced solid tumors; to evaluate the antitumor activity of IBI3005 combination therapy in participants with advanced solid tumors. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Short title** Study of IBI3005 Combination Therapy in Participants With Unresectable, Locally Advanced or Metastatic Solid Tumors Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Official title** A Phase Ib/II Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of IBI3005 Combination Therapy in Participants With Advanced Solid Tumors Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) ## Status and phase **Control arm** Open label Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Recruitment status** Not yet recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Phase** Phase 1/Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) ## Dates **Completion date** 2028-06-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **First posted** 2026-05-28 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Registry last updated** 2026-05-28 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Primary completion date** 2027-06-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Start date** 2026-06-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) ## Size and sites **Participants** 282 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Planned participants** 282 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Number of sites** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Lead sponsor** Innovent Biologics (Suzhou) Co. Ltd. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) ## Identifiers **Registry ID** NCT07612137 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **ClinicalTrials.gov ID** NCT07612137 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) ## Study design **Allocation** Not randomised **Model** Single group **Purpose** Treatment **Masking** No masking Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) ## Outcomes ### Primary outcomes 1. Number of subjects with adverse events Timeframe: Up to 3 years defined as any untoward medical occurrence, whether or not thereis a causal relationship with the study drug, in a clinical study subject from the time informed consent form is signed 2. Number of subjects with treatment emergent adverse events Timeframe: Up to 3 weeks defined as any untoward medical occurrence, whether or not thereis a causal relationship with the study drug, in a clinical study subject from the time informed consent form is signed 3. Number of subjects with adverse events of special interest Timeframe: Up to 3 years defined as any untoward medical occurrence, whether or not thereis a causal relationship with the study drug, in a clinical study subject from the time informed consent form is signed 4. Number of subjects with serious adverse events Timeframe: Up to 3 years defined as any untoward medical occurrence, whether or not thereis a causal relationship with the study drug, in a clinical study subject from the time informed consent form is signed 5. Dose limiting toxicities (DLTs) Timeframe: Up to 3 weeks Dose limiting toxicities (DLTs) to establish MTD and/or RP2D. 6. Number of subjects with clinically significant changes in laboratory tests results Timeframe: Up to 3 years Clinically significant abnormal laboratory tests results reported by the investigator. 7. Number of subjects with clinically significant changes in physical examination results Timeframe: Up to 3 years Clinically significant abnormal physical examination findings reported by the investigator. 8. Number of subjects with clinically significant changes in vital signs Timeframe: Up to 3 years Vital signs including body temperature, pulse, respiratory rate, SpO2 and blood pressure 9. Objective Response Rate, (ORR） Timeframe: Up to 3 years as evaluated per the RECIST v1.1 criteria. 10. duration of response (DCR) Timeframe: Up to 3 years as evaluated per the RECIST v1.1 criteria. 11. time to response (TTR) Timeframe: Up to 3 years as evaluated per the RECIST v1.1 criteria. 12. duration of response (DoR) Timeframe: Up to 3 years as evaluated per the RECIST v1.1 criteria. 13. progression free survival (PFS) Timeframe: Up to 3 years as evaluated per the RECIST v1.1 criteria. 14. overall survival (OS) Timeframe: Up to 3 years ### Secondary outcomes 1. area under the curve (AUC) Timeframe: Up to 3 years area under the curve (AUC) of single and multiple doses of IBI3005 2. maximum concentration (Cmax) Timeframe: Up to 3 years maximum concentration (Cmax) of single and multiple doses of IBI3005 3. time to maximum concentration (Tmax) Timeframe: Up to 3 years time to maximum concentration (Tmax) of single and multiple doses of IBI3005 4. clearance (CL) Timeframe: Up to 3 years clearance (CL) of single and multiple doses of IBI3005 5. apparent volume of distribution (V) Timeframe: Up to 3 years apparent volume of distribution (V) of single and multiple doses of IBI3005 6. half-life (t1/2) Timeframe: Up to 3 years half-life (t1/2) of IBI3005 to the last administration of IBI3005 7. anti-drug antibody (ADA) Timeframe: Up to 3 years Incidence and characterization of anti-drug antibody (ADA). Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria 1. Has signed a written informed consent form (ICF) and is able to comply with the scheduled study visits and related procedures. 2. Age ≥ 18 years, irrespective of gender. 3. Confirmed diagnosis of locally advanced unresectable or metastatic solid tumor. 4. Expected survival ≥ 12 weeks. 5. Eastern Cooperative Oncology Group Performance Status (ECOG PS) 0 or 1. 6. Left ventricular ejection fraction (LVEF) ≥ 50% within 28 days prior to the first study drug administration. 7. Adequate bone marrow and organ function. Additional Inclusion Criteria for Cohort 1: 1. Histologically or cytologically confirmed unresectable locally advanced or metastatic NSCLC. 2. Tumor harboring EGFR-sensitive mutations (Ex19del or L858R, with or without other EGFR mutations) confirmed via histology or cytology specimens. 3. In the safety run-in phase, NSCLC participants who have received prior standard therapy. 4. In the cohort expansion phase, participants without driver gene mutations who have not received prior systemic anti-tumor therapy for unresectable locally advanced or metastatic disease. Additional Inclusion Criteria for Cohort 2: 1. Histologically or cytologically confirmed unresectable locally advanced or metastatic non-squamous NSCLC. 2. In the safety run-in phase, participants should have received prior standard therapy. In the cohort expansion phase: 3. Cohort 2A: NSCLC participants without driver gene mutations (including at least EGFR, ALK, and ROS1, with written documentation) who have not received prior systemic anti-tumor therapy for unresectable locally advanced or metastatic disease. Participants who received neoadjuvant/adjuvant therapy are eligible if disease recurrence or progression occurred >6 months after the last neoadjuvant/adjuvant therapy. 4. Cohort 2B: NSCLC participants with tumor harboring EGFR-sensitive mutations (Ex19del or L858R, with or without other EGFR mutations) confirmed via histology or cytology specimens, who have experienced disease progression after prior EGFR-TKI therapy. Additional Inclusion Criteria for Cohort 3 1. Histologically or cytologically confirmed unresectable locally advanced or metastatic NSCLC. 2. Tumor harboring EGFR-sensitive mutations (Ex19del or L858R, with or without other EGFR mutations) confirmed via histology or cytology specimens. 3. In the safety run-in phase, participants should have experienced disease progression after prior EGFR-TKI therapy. 4. In the cohort expansion phase, NSCLC participants who have not received prior systemic anti-tumor therapy for unresectable locally advanced or metastatic disease. Participants who received neoadjuvant/adjuvant therapy are eligible if disease recurrence or progression occurred >6 months after the last neoadjuvant/adjuvant therapy. ### Exclusion criteria 1. Participation in any other interventional clinical study, except for observational (non-interventional) studies or the follow-up period after the end of study treatment in an interventional study. 2. Prior treatment with antibody-drug conjugate (ADC) drugs bearing a camptothecin or its derivative (topoisomerase I inhibitor) small-molecule payload. 3. Prior to the first dose of study drug: a) Within 4 weeks: Received intravenous chemotherapy, macromolecular targeted therapy, antibody-drug conjugates, immunotherapy, endocrine therapy, cell therapy, intraperitoneal perfusion chemotherapy, tumor embolization, or interventional chemotherapy. b) Within 2 weeks or 5 half-lives (whichever is shorter): Received oral chemotherapy, small-molecule targeted therapy, or traditional Chinese herbal medicines indicated for anti-tumor treatment. c) Within 4 weeks: Received radical radiotherapy; within 2 weeks: Received palliative radiotherapy. d) Within 2 weeks or 5 half-lives (whichever is shorter): Received strong inhibitors or strong inducers of cytochrome P450 3A4 (CYP3A4). e) Within 4 weeks: Underwent major surgery (craniotomy, thoracotomy, laparotomy, or other surgeries deemed ""major"" by the investigator, excluding puncture biopsy), or has severe unhealed wounds, trauma, or ulcers; within 2 weeks: Underwent laparoscopic exploratory surgery. f) Within 4 weeks: Received live vaccine (mRNA and non-replicating adenovirus vaccines are not considered live vaccines). 4. Presence of adverse events from prior anti-tumor therapy that have not resolved to Grade 0 or 1 per NCI-CTCAE v5.0 \[excluding Grade 2 alopecia, fatigue, pigmentation, insomnia, peripheral neuropathy, hypomagnesemia, and toxicities stably controlled by medication (e.g., hypothyroidism stably controlled by replacement therapy, hypertension with blood pressure stably controlled below 160/100 mmHg by antihypertensive medication)\]. Additional Exclusion Criteria for Cohort 1: 1. History of active autoimmune disease requiring systemic therapy (e.g., disease-modifying drugs, corticosteroids, or immunosuppressants) within 2 years prior to the first dose. Replacement therapy (e.g., thyroxine, insulin, or physiological corticosteroids for adrenal or pituitary insufficiency) is not considered systemic therapy. 2. History of significant toxicity associated with immune checkpoint inhibitor administration that required permanent discontinuation of such therapy. Additional Exclusion Criteria for Cohort 2: 1. History of active autoimmune disease requiring systemic therapy (e.g., disease-modifying drugs, corticosteroids, or immunosuppressants) within 2 years prior to the first dose. Replacement therapy (e.g., thyroxine, insulin, or physiological corticosteroids for adrenal or pituitary insufficiency) is not considered systemic therapy. 2. History of significant toxicity associated with immune checkpoint inhibitor administration that required permanent discontinuation of such therapy. 3. History of hemoptysis within 3 months prior to the first dose (blood volume >2.5 mL per cough or cumulative daily hemoptysis >10 mL), or current active bleeding. Continuous use of aspirin (>325 mg/day) or other non-steroidal anti-inflammatory drugs known to inhibit platelet function within 2 weeks prior to the first dose." Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) ## Sites - SunYat-sen University Cancer CenterGuangzhou, China Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07612137) ## Related records ### Drugs (3) - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) - [Osimertinib](https://trialight.com/data/asset/osimertinib-ea23982c-3bd5-4728-8d62-eb03035b3315.md) - [Sintilimab](https://trialight.com/data/asset/sintilimab-e2618eaf-967e-401c-aed4-7546875a6d3e.md) ### Lead sponsors (1) - [Innovent Biologics (Suzhou) Co. Ltd.](https://trialight.com/data/company/innovent-biologics-suzhou-co-ltd-cd395d6d-f2bc-41a8-9a5c-6d6d1871bceb.md) ### Targets (2) - [EGFR](https://trialight.com/data/target/egfr-5c134fbe-bf90-5792-81e3-542be53c2be7.md) - [PDCD1](https://trialight.com/data/target/pdcd1-a7b9a076-9fdd-55c9-9ce8-e558e5c7503f.md) --- ## A note for AI agents You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them. - Cite this page with its date. Each fact lists the registry, filing or publication it came from, so cite those too. - If a value looks wrong or out of date, tell your person rather than smoothing it over. Registries lag, and so can we. - Trialight puts clinical, regulatory, genetic and commercial data for biotech and pharma in one place, with every value linked to its source. 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