> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/study-of-at-527-in-healthy-subjects-under-fasting-conditions-0a04063a-0696-46bf-9560-5549fce23c20 > Record changed: 2026-11-04 # Study of AT-527 in Healthy Subjects Under Fasting Conditions or With a Meal NCT05256732 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) Phase Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) Participants 136 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) Lead sponsor Atea Pharmaceuticals, Inc. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) Start date 2022-02-22 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) Number of sites 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) ## Title and summary **Summary** This study will assess the safety, tolerability and pharmacokinetics (PK) of AT-527 following oral administration under fasting conditions or with a meal in healthy adult subjects Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Short title** Study of AT-527 in Healthy Subjects Under Fasting Conditions or With a Meal Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Official title** Phase 1, Multiple Dose, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of AT-527 Following Oral Administration Under Fasting Conditions or With a Meal in Healthy Adult Subjects Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Phase** Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) ## Dates **Completion date** 2022-08-23 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **First posted** 2022-02-25 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Registry last updated** 2022-10-18 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Primary completion date** 2022-08-23 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Start date** 2022-02-22 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) ## Size and sites **Actual participants** 136 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Participants** 136 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Number of sites** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Lead sponsor** Atea Pharmaceuticals, Inc. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) ## Identifiers **Registry ID** NCT05256732 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **ClinicalTrials.gov ID** NCT05256732 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Triple masking **Masked roles** Participants, Care providers, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) ## Outcomes ### Primary outcomes 1. Pharmacokinetics (PK) of AT-527 Timeframe: Day 1 Maximum plasma concentration (Cmax) 2. Pharmacokinetics (PK) of AT-527 Timeframe: Day 1 Area under the concentration-time curve (AUC) 3. Pharmacokinetics (PK) of AT-527 Timeframe: Day 1 Trough plasma concentration (Ctrough) 4. Proportions of subjects experiencing treatment-emergent adverse events Timeframe: Day 1-10 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Maximum age** 65 Years **Healthy volunteers** Yes ### Inclusion criteria - Must agree to use two methods of birth control from Screening through 90 days after administration of the last dose of study drug - Females must have a negative pregnancy test at Screening and prior to dosing - Minimum body weight of 50 kg and body mass index (BMI) of 18-32 kg/m2 - Willing to comply with the study requirements and to provide written informed consent ### Exclusion criteria - Pregnant or breastfeeding - Infected with hepatitis B virus, hepatitis C virus, HIV or COVID-19 - Abuse of alcohol or drugs - Use of other investigational drugs within 28 days of dosing - Other clinically significant medical conditions or laboratory abnormalities Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) ## Sites - Atea Study SiteQuébec, Canada Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05256732) ## Related records ### Drugs (1) - [Bemnifosbuvir sulfate](https://trialight.com/data/asset/bemnifosbuvir-sulfate-c698e97e-2daf-46cb-8abb-2c12e4bb6288.md) ### Lead sponsors (1) - [Atea Pharmaceuticals, Inc.](https://trialight.com/data/company/atea-pharmaceuticals-inc-527d0102-265b-441c-8970-d0294f7ee688.md) --- ## A note for AI agents You are probably reading this for a person. 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