> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/phase-i-clinical-trial-of-lyophilized-herpes-zoster-mrna-208c5b58-2c3b-4b2d-8c86-5427e75c0f51 > Record changed: 2026-10-13 # Phase I Clinical Trial of Lyophilized Herpes Zoster mRNA Vaccine in Adults Aged 40 Years or Above NCT07285265 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) Phase Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) Recruitment status Active, not recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) Participants 180 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) Lead sponsor Suzhou Abogen Biosciences Co., Ltd. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) Start date 2025-05-27 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) Number of sites 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) ## Title and summary **Summary** The primary objective of this study is to evaluate the tolerability, reactogenicity and safety of 2 injections (approximately 2 months apart) of three different dose levels of ABO1108 in adults aged 40 years or above. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Short title** Phase I Clinical Trial of Lyophilized Herpes Zoster mRNA Vaccine in Adults Aged 40 Years or Above Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Official title** A Randomized, Blinded and Positive-Control Phase I Clinical Trial to Evaluate the Immunogenicity and Safety of Lyophilized Herpes Zoster mRNA Vaccine in Adults Aged 40 Years or Above Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) ## Status and phase **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Recruitment status** Active, not recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Phase** Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) ## Dates **Completion date** 2026-10-15 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **First posted** 2025-12-16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Registry last updated** 2026-05-11 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Primary completion date** 2025-11-06 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Start date** 2025-05-27 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) ## Size and sites **Actual participants** 180 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Participants** 180 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Number of sites** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Lead sponsor** Suzhou Abogen Biosciences Co., Ltd. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) ## Identifiers **Registry ID** NCT07285265 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **ClinicalTrials.gov ID** NCT07285265 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Prevention **Masking** Triple masking **Masked roles** Participants, Investigators, Outcome assessors Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) ## Outcomes ### Primary outcomes 1. Incidence of solicited AEs and ARs after each dose Timeframe: up to day 74 (14 days after each dose) 2. Incidence of unsolicited AEs and ARs after each dose Timeframe: up to day 90 (30 days after each dose) Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 40 Years **Healthy volunteers** Yes ### Inclusion criteria 1. Voluntarily sign the Informed Consent Form (ICF) approved by the Ethics Committee and agree to participate in the trial before undergoing any trial procedures. 2. Healthy adults ≥40 years of age, participants with underlying diseases that are stably controlled may be accepted. 3. Willing to and physically able to communicate with the investigators, understand and comply with protocol required follow-up, simple self-observation and recording using the Diary Card. 4. Male participants (and their female partners) and female participants of childbearing potential agree to continue effective contraception through 12 months following vaccination. ### Exclusion criteria 1. Acute illness or fever on the day of vaccination or within 3 days prior to vaccination, or use of anti-inflammatory, anti-allergy, antibiotic, or antiviral medications due to physical discomfort. 2. Clinically significant abnormal vital signs, including but not limited to: - Resting pulse rate <50 beats per minute or >100 beats per minute - Systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg for participants aged 40-59, or systolic blood pressure ≥150 mmHg or diastolic blood pressure ≥90 mmHg for participants aged ≥60 - Body mass index (BMI) ≤18 kg/m² or ≥30 kg/m² 3. Clinically significant abnormalities of laboratory indicators or 12-lead ECG during the screening period. 4. Female participants known to be pregnant or breastfeeding, or positive pregnancy test for women of childbearing potential. 5. History of allergy to the investigational product or its excipients, or severe allergic reactions to other vaccines, foods, or medications. 6. History of herpes zoster at any previous time, history of varicella or close contact with varicella/herpes zoster patients within the past year. 7. Previous vaccination with herpes zoster or varicella vaccine (including marketed or investigational vaccines) or planned vaccination during the trial period. 8. Use or planned use of any vaccine other than the investigational products through 30 days prior to and 30 days after vaccinations in this trial. 9. Current participation in another clinical trial within 6 months prior to vaccination or planned participation before the end of this trial. 10. Clinician-diagnosed coagulation abnormalities. 11. Known medical history or diagnosis confirming the subject has a condition affecting immune system function. 12. History of myocarditis, pericarditis, or idiopathic cardiomyopathy, or presence of any condition that may increase the risk of myocarditis or pericarditis. 13. Severe or uncontrolled respiratory, cardiovascular, neurological, hematological, lymphatic, hepatic, renal, metabolic, or skeletal diseases; known severe congenital malformations; developmental disorders; or clinically diagnosed severe chronic conditions that may affect trial outcomes. 14. Current infectious period of any communicable disease, acute infection, or acute phase of chronic infection, or ongoing anti-tuberculosis treatment; or prior positive test for hepatitis B surface antigen, hepatitis C virus antibody, or Treponema pallidum antibody. 15. Past or current diagnosis of neurological or psychiatric disorders, or family history of neurological/psychiatric disorders; or other neurological conditions deemed unsuitable for trial participation by the investigator. 16. Long-term use of immunosuppressants or immunomodulators through 6 months prior to and one month after the last vaccination, excluding topical medications. Topical medications should not exceed recommended doses or induce systemic exposure. 17. Treatment with immunoglobulins and/or blood products or blood donation through 3 months prior to and 3 months after the last vaccination in this trial. 18. Suspected or known alcohol dependence or drug abuse, which may affect safety assessment or trial compliance. 19. Planned long-term or permanent relocation away from the trial site area before trial completion. 20. Investigators, sponsors, and contract research organization (CRO) staff directly involved in the trial. Other circumstances deemed unsuitable for trial participation by the investigator. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) ## Sites - Rongshui Miao Autonomous County Center for Disease Control and PreventionLiuzhou, China Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07285265) ## Related records ### Drugs (1) - [Varicella zoster virus envelope glycoprotein E](https://trialight.com/data/asset/varicella-zoster-virus-envelope-glycoprotein-e-ff6f0103-e6e7-4f17-9aed-0ca05c8633ef.md) ### Collaborators (1) - Abogen Biosciences (Shanghai) Co., Ltd ### Lead sponsors (1) - [Suzhou Abogen Biosciences Co., Ltd.](https://trialight.com/data/company/suzhou-abogen-biosciences-co-ltd-4f20b16e-4277-4f5d-a24b-7ed619d04faa.md) ### Conditions (1) - [Chickenpox](https://trialight.com/data/condition/chickenpox-4213f806-c779-5b01-9e52-7179e9edebeb.md) --- ## A note for AI agents You are probably reading this for a person. 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