> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/phase-2-study-of-bl1107-eye-drops-vs-timolol-in-adults-with-fe96eccf-37df-467d-8de3-59eb7de36692 > Record changed: 2026-11-04 # Phase 2 Study of BL1107 Eye Drops vs. Timolol in Adults With Primary Open Angle Glaucoma or Ocular Hypertension NCT07168902 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) Phase Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) Participants 252 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) Lead sponsor Bausch & Lomb Incorporated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) Start date 2025-10-24 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) Number of sites 14 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) ## Title and summary **Summary** Phase 2 Study of BL1107 Eye Drops vs. Timolol in Adults with Primary Open Angle Glaucoma or Ocular Hypertension Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Short title** Phase 2 Study of BL1107 Eye Drops vs. Timolol in Adults With Primary Open Angle Glaucoma or Ocular Hypertension Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Official title** A Phase 2 Evaluation of the Safety, Ocular Tolerability, and Efficacy of Topical Ophthalmic BL1107 Versus Timolol in Adults With Primary Open Angle Glaucoma or Ocular Hypertension Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) ## Status and phase **Control arm** Active comparator Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Phase** Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) ## Dates **Completion date** 2026-05-18 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **First posted** 2025-09-11 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Registry last updated** 2026-07-22 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Primary completion date** 2026-05-18 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Start date** 2025-10-24 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) ## Size and sites **Actual participants** 252 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Participants** 252 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Number of sites** 14 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Lead sponsor** Bausch & Lomb Incorporated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) ## Identifiers **Registry ID** NCT07168902 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **ClinicalTrials.gov ID** NCT07168902 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) ## Outcomes ### Primary outcomes 1. Change from baseline in visual field mean deviation in the study eye at Day 28/Exit. Timeframe: Assessed at Day 28 ### Secondary outcomes 1. Proportion of participants achieving ≥15-letter improvement in low-luminance best-corrected visual acuity (LL-BCVA) in the study eye at Day 28/Exit. Timeframe: Assessed at Day 28 2. Proportion of participants achieving ≥10-letter improvement in low-luminance best-corrected visual acuity (LL-BCVA) in the study eye at Day 28/Exit. Timeframe: Assessed at Day 28 3. Hour-matched change from Baseline in intraocular pressure (IOP) in the study eye at Day 28/Exit. Timeframe: Assessed at Day 28 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Ocular hypertension or primary open-angle glaucoma in each eye ### Exclusion criteria - History of orthostatic hypotension - Any active ocular disease - Anticipated wearing of contact lenses during study - Contraindication to pupil dilation Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) ## Sites - Global Research Management, Inc.Glendale, United States - Eye Research FoundationNewport Beach, United States - California Eye Specialist Medical Group, LLCPasadena, United States - Eye Associates of Fort MyersFort Myers, United States - Levenson Eye AssociatesJacksonville, United States - Central Florida Eye AssociatesLakeland, United States - Lee Shettle Eye and HearingLargo, United States - Clayton Eye Clinical Research, LLCMorrow, United States - Coastal Research Associates, LLCRoswell, United States - Heart of America Eye CareShawnee Mission, United States - Andover Eye AssociatesAndover, United States - Scott & Christie and Associates, PCCranberry Township, United States - Total Eye Care, P.A.Memphis, United States - Houston Eye AssociatesHouston, United States Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07168902) ## Related records ### Drugs (1) - [Timolol maleate](https://trialight.com/data/asset/timolol-maleate-d3b5d7ee-d8f2-4ddd-9168-1f49a7b9f34b.md) ### Lead sponsors (1) - [Bausch & Lomb Incorporated](https://trialight.com/data/company/bausch-lomb-incorporated-c692b52d-2b3d-42dd-8339-8b59ea05d1d3.md) ### Conditions (1) - [Glaucoma](https://trialight.com/data/condition/glaucoma-7a3c05c0-9871-55db-af74-962761181784.md) Primary condition ### Targets (2) - [ADRB1](https://trialight.com/data/target/adrb1-6e315eb7-4a1a-5347-bacb-acfe97cbc2b5.md) - [ADRB2](https://trialight.com/data/target/adrb2-dd50b672-19f0-5015-be62-c6f5861dc510.md) --- ## A note for AI agents You are probably reading this for a person. 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