> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/ocean-a-preevent-olpasiran-trials-of-cardiovascular-events-93287d62-8a71-40cf-b1b3-9897448a6941 > Record changed: 2026-10-13 # OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events NCT07136012 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) Participants 11,000 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) Lead sponsor Amgen Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) Start date 2025-08-22 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) Number of sites 252 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) ## Title and summary **Summary** The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\\\[a\\\]). Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Short title** OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Official title** A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing Olpasiran Use to Prevent First Major Cardiovascular Events in Participants With Elevated Lipoprotein(a) Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) ## Dates **Completion date** 2031-10-20 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **First posted** 2025-08-22 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Registry last updated** 2026-08-21 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Primary completion date** 2031-10-20 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Start date** 2025-08-22 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) ## Size and sites **Participants** 11,000 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Planned participants** 11,000 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Number of sites** 252 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Lead sponsor** Amgen Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) ## Identifiers **Registry ID** NCT07136012 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **ClinicalTrials.gov ID** NCT07136012 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) ## Outcomes ### Primary outcomes 1. Time to CHD Death, Myocardial Infarction, or Urgent Coronary Revascularization, Whichever Occurs First Timeframe: Up to approximately 6.2 years ### Secondary outcomes 1. Time to Cardiovascular Death, Myocardial Infarction, or Ischemic Stroke, Whichever Occurs First Timeframe: Up to approximately 6.2 years 2. Time to Cardiovascular Death, Myocardial Infarction, Urgent Coronary Revascularization, or Ischemic Stroke, Whichever Occurs First Timeframe: Up to approximately 6.2 years 3. Percent Change From Baseline to Week 48 Lp(a) Levels Timeframe: Baseline and Week 48 4. Time to Myocardial Infarction Timeframe: Up to approximately 6.2 years 5. Time to CHD Death or Myocardial Infarction, Whichever Occurs First Timeframe: Up to approximately 6.2 years 6. Time to Urgent Coronary Revascularization Timeframe: Up to approximately 6.2 years 7. Time to Coronary Revascularization Timeframe: Up to approximately 6.2 years 8. Time to CHD Death Timeframe: Up to approximately 6.2 years 9. Time to Cardiovascular Death Timeframe: Up to approximately 6.2 years 10. Time to Death by any Cause Timeframe: Up to approximately 6.2 years 11. Time to Ischemic Stroke Timeframe: Up to approximately 6.2 years 12. Serum Concentration of Olpasiran Timeframe: Up to Week 48 13. Number of Participants with Treatment Emergent Adverse Events (TEAEs) Timeframe: Up to approximately 6.2 years Including serious adverse events and adverse events leading to discontinuation of investigational product. Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 50 Years **Maximum age** 105 Years **Healthy volunteers** No ### Inclusion criteria - Age ≥50 years - Lp(a)≥ 200 nmol/L during screening - Multiple atherosclerotic cardiovascular disease risk factors, and/or evidence of atherosclerosis ### Exclusion criteria - Prior acute atherothrombotic event (myocardial infarction, stroke, transient ischemic attack, acute limb ischemia) - Prior or planned arterial revascularization - History of major bleeding disorder Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) ## Sites - Advanced Cardiovascular LLCAlexander City, United StatesRecruiting - University of Alabama Birmingham Saint Vincents BirminghamBirmingham, United StatesRecruiting - Birmingham Clinical ResearchBirmingham, United StatesRecruiting - Alliance For Multispecialty Research - DaphneDaphne, United StatesRecruiting - Eastern Shore Research InstituteFairhope, United StatesRecruiting - Heart Center Research LLCHuntsville, United StatesRecruiting - CB Flock Research CorporationMobile, United StatesRecruiting - Phoenix ClinicalPhoenix, United StatesRecruiting - Elite Clinical Studies LLCPhoenix, United StatesRecruiting - Hero Clinical ResearchPhoenix, United StatesRecruiting - HonorHealth Research InstituteScottsdale, United StatesRecruiting - Eclipse Clinical ResearchTucson, United StatesRecruiting - Lynn Institute of the OzarksLittle Rock, United StatesRecruiting - National Heart InstituteBeverly Hills, United StatesRecruiting - 310 Clinical ResearchInglewood, United StatesRecruiting - University of California San DiegoLa Jolla, United StatesRecruiting - InvivoCureLos Angeles, United StatesRecruiting - Valley Clinical TrialsNorthridge, United StatesRecruiting - Clinical Trials Research - SacramentoRoseville, United StatesRecruiting - Alliance Clinical ResearchSan Diego, United StatesRecruiting - Encompass Clinical ResearchSpring Valley, United StatesRecruiting - Stanford Health CareStanford, United StatesRecruiting - Manshadi Heart InstituteStockton, United StatesRecruiting - Blue Coast CardiologyVista, United StatesRecruiting - Diablo Clinical ResearchWalnut Creek, United StatesRecruiting And 227 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) ## References - Related resource (www.amgentrials.com) Source: [www.amgentrials.com](http://www.amgentrials.com/) Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07136012) ## Related records ### Drugs (1) - [Olpasiran](https://trialight.com/data/asset/olpasiran-d8fbc30c-c4b4-48a4-88d9-298c3f3918bb.md) ### Lead sponsors (1) - [Amgen](https://trialight.com/data/company/amgen-e0106b98-aeaf-49cc-b95a-04f4be619a07.md) ### Conditions (3) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Primary condition - [Coronary artery disorder](https://trialight.com/data/condition/coronary-artery-disorder-6f736849-d477-587a-b3fa-b0621d573407.md) - [Myocardial infarction](https://trialight.com/data/condition/myocardial-infarction-b4e97483-7435-5701-81dc-26d955e420ec.md) ### Targets (1) - [LPA](https://trialight.com/data/target/lpa-7605327a-3607-533b-955f-c9eff32d6732.md) --- ## A note for AI agents You are probably reading this for a person. 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