> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/letrozole-alone-protocol-versus-using-letrozole-and-hcg-a3cbfa68-4ce7-4f5e-b3b5-15e35d775255 > Record changed: 2026-11-04 # Letrozole Alone Protocol Versus Using Letrozole and HCG Protocol NCT06367712 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) Phase Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) Participants 132 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) Lead sponsor Egymedicalpedia Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) Start date 2022-11-10 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) Number of sites 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) ## Title and summary **Summary** Letrozole is a chemical compound, CGS 20267 which is a third-generation, nonsteroidal aromatase inhibitor. Letrozole blocks estrogen synthesis by directly affecting the hypothalamic-pituitary-ovarian axis, subsequently, increases gonadotropins which increase pregnancy rates. Possible positive outcomes of aromatase inhibitors over selective estrogen-receptor modulators include a more physiologic hormonal stimulation of the endometrium which increases receptivity, a lower multiple-pregnancy through single follicle growth, a lesser side-effect especially vasomotor and mood symptoms, and more prompt clearance from blood, hence, reducing the probabilities of periconceptional exposure Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Short title** Letrozole Alone Protocol Versus Using Letrozole and HCG Protocol Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Official title** The Effect of Using Letrozole Alone Protocol Versus Using Letrozole and HCG Protocol on Induction of Ovulation in Polycystic Ovarian Syndrome Patients: A Prospective Cohort Study Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) ## Status and phase **Control arm** Active comparator Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Phase** Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) ## Dates **Completion date** 2023-11-10 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **First posted** 2024-04-16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Registry last updated** 2024-04-16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Primary completion date** 2023-11-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Start date** 2022-11-10 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) ## Size and sites **Actual participants** 132 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Participants** 132 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Number of sites** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Lead sponsor** Egymedicalpedia Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) ## Identifiers **Registry ID** NCT06367712 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **ClinicalTrials.gov ID** NCT06367712 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Single masking **Masked roles** Participants Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) ## Outcomes ### Primary outcomes 1. Pregnancy test Timeframe: 2 weeks after ovulation The participants required to make pregnancy test after taking the drugs of the study Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) ## Eligibility **Sex** Female **Age groups** Adults **Minimum age** 18 Years **Maximum age** 35 Years **Healthy volunteers** No ### Inclusion criteria - Infertile women with PCOS - Normal hysterosalpingography - Normal semen analysis according to WHO parameters are major prerequisites ### Exclusion criteria - Infertile women with causes other than PCOS, - Ages <18 or >35 years - women taken confounding medications like other infertility drugs - Insulin sensitizers or hormones - Abnormal hysterosalpingography - Subnormal semen analysis Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) ## Sites - Ahmed Maher Teaching HospitalCairo, Egypt Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06367712) ## Related records ### Drugs (1) - [Letrozole](https://trialight.com/data/asset/letrozole-67319198-7e88-4130-b185-d776c835863c.md) ### Lead sponsors (1) - [Egymedicalpedia](https://trialight.com/data/company/egymedicalpedia-acb05d45-26ff-47dc-abf4-9f76a069c322.md) ### Conditions (1) - [Polycystic ovary syndrome](https://trialight.com/data/condition/polycystic-ovary-syndrome-441e4a14-977c-536f-a5ad-0c5be955054b.md) Primary condition ### Targets (1) - [CYP19A1](https://trialight.com/data/target/cyp19a1-9682b33b-ed66-55a7-8155-bf00584059c7.md) --- ## A note for AI agents You are probably reading this for a person. 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