> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/hh-120-nasal-spray-for-post-exposure-prevention-of-sars-cov-8bcae664-f836-4d0e-94e6-6b5764b6638f > Record changed: 2026-10-13 # HH-120 Nasal Spray for Post-exposure Prevention of SARS-CoV-2 NCT05787418 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) Recruitment status Enrolling by invitation Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) Participants 1,200 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) Lead sponsor Huahui Health Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) Start date 2023-03-31 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) Number of sites 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) ## Title and summary **Summary** This study will assess the efficacy of HH-120 nasal spray in participants for the post-exposure prevention of SARS-CoV-2. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Short title** HH-120 Nasal Spray for Post-exposure Prevention of SARS-CoV-2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Official title** A Phase III, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of HH-120 Nasal Spray for Post-exposure Prophylaxis of SARS-CoV-2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Recruitment status** Enrolling by invitation Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) ## Dates **Completion date** 2026-04-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **First posted** 2023-03-28 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Registry last updated** 2024-10-10 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Primary completion date** 2025-12-31 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Start date** 2023-03-31 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) ## Size and sites **Participants** 1,200 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Planned participants** 1,200 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Number of sites** 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Lead sponsor** Huahui Health Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) ## Identifiers **Registry ID** NCT05787418 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **ClinicalTrials.gov ID** NCT05787418 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Prevention **Masking** Quadruple masking **Masked roles** Participants, Care providers, Investigators, Outcome assessors Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) ## Outcomes ### Primary outcomes 1. The incidence of symptomatic SARS-CoV-2 infection Timeframe: Up to 7 days Incidence of participants with quantitative Real-Time polymerase chain reaction (qRT-PCR) confirmed SARS-CoV-2 infection and COVID-19 related symptom ### Secondary outcomes 1. The incidence of SARS-CoV-2 infection Timeframe: Up to 7 days 2. The changes in SARS-CoV-2 viral nucleic acid load Timeframe: Up to 7 days 3. The change of viral load by qRT-PCR Timeframe: Up to 7 days 4. Incidence and severity of adverse events Timeframe: Up to 21 days 5. The incidence of symptomatic SARS-CoV-2 infection Timeframe: Up to 3 days 6. The incidence of symptomatic SARS-CoV-2 infection Timeframe: Up to 5 days 7. Time to onset of first COVID-19 related symptom Timeframe: Up to 7 days 8. Proportion of participants who progress to moderate/severe/critical type of COVID-19 or death Timeframe: Up to 21 days 9. The incidence of symptomatic SARS-CoV-2 infection in different subgroups Timeframe: Up to 7 days 10. The incidence and titer of antidrug antibody (ADA) Timeframe: Up to 21 days Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) ## Eligibility **Sex** All **Age groups** Children, Adults, Older adults **Minimum age** 12 Years **Maximum age** 85 Years **Healthy volunteers** No ### Inclusion criteria - 12 to 85 years old. - Participants with potential exposure to index patients (with known positive result of qRT-PCR or rapid antigen test \[RAT\]). - Participants will be randomized no longer than 48 hours from the onset of the COVID-19 related symptom of the index patients. - Participants with a negative RAT result within 2 hours prior to randomization. - Fertile participants must agree to use a highly effective method of contraception. - Participants being able and willing to provide informed consent prior to any study-specific procedure. ### Exclusion criteria - Those with high risk of cardiac events, or severe abnormal functions of liver, kidney, lung, brain and other organs and are deemed as unsuitable to participate in the study (except for those subjects with kidney failure but received regular dialysis, or those with liver dysfunction but stabilized after treatment evaluated by the evaluation of the investigators). - Those comorbid with asthma. - Those with a history of SARS-CoV-2 infection within 3 months prior to randomization. - Those who has received any nasal spray or aerosol inhalation COVID-19 vaccine within 3 months prior to randomization. - Those who experienced symptom of upper respiratory tract infection within 2 weeks prior to randomization, such as nasal congestion, sore throat, shortness of breath (dyspnea), cough, fatigue, fever, headache, etc. - Known history of allergy or reaction to any component of the study drug formulation. - Those who has received other treatment with anti-COVID-19 indication (within 1 month or 5 half-life period prior to randomization, whichever occurs first). - Participants with nasal disease that is inconvenient or intolerant of nasal spray administration. - Other reasons considered by the investigator to be unsuitable for the study. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) ## Sites - Beijing Ditan Hospital, Capital Medical UniversityBeijing, China - Huashan Hospital of Fudan UniversityShanghai, China Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05787418) ## Related records ### Drugs (1) - [Oxytocin](https://trialight.com/data/asset/oxytocin-787cf970-fce1-4bab-b1c9-6d816e9784fb.md) ### Lead sponsors (1) - [Huahui Health](https://trialight.com/data/company/huahui-health-62e83905-1703-4fda-aa81-040a229bffed.md) ### Conditions (1) - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Primary condition ### Targets (1) - [OXTR](https://trialight.com/data/target/oxtr-0754c97c-91cc-5451-9d2f-ebf7271cf9f7.md) --- ## A note for AI agents You are probably reading this for a person. 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