> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/efficacy-and-safety-of-ribupatide-administered-once-weekly-45d86a3e-3a40-45e4-87eb-be4b574d95cd > Record changed: 2026-10-13 # Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes NCT07284979 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) Participants 1,200 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) Lead sponsor Kailera Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) Start date 2025-12-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) Number of sites 53 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) ## Title and summary **Summary** The primary objective of this study is to demonstrate that ribupatide (KAI-9531) subcutaneous (SC) injection once weekly is superior to semaglutide SC once weekly and to placebo SC once weekly on percent change in body weight. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Acronym** KaiNETIC-3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Short title** Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Official title** A Phase 3, Randomized, Active- and Placebo-Controlled, Partially-Blinded Study to Compare the Efficacy and Safety of KAI-9531 Administered Once Weekly Versus Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) ## Dates **Completion date** 2028-04-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **First posted** 2025-12-16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Registry last updated** 2026-07-22 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Primary completion date** 2028-03-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Start date** 2025-12-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) ## Size and sites **Participants** 1,200 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Planned participants** 1,200 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Protocol amendments** 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Number of sites** 53 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Lead sponsor** Kailera Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) ## Identifiers **Registry ID** NCT07284979 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **ClinicalTrials.gov ID** NCT07284979 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masking description** The participant and investigator will be blinded for participants randomized to ribupatide or placebo until the study is complete. Semaglutide will be provided open label. **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) ## Outcomes ### Primary outcomes 1. Percent Change From Baseline in Body Weight at Week 76 Timeframe: Baseline, Week 76 ### Secondary outcomes 1. Percentage of Participants with ≥10%, ≥15%, ≥20% and ≥25% Reduction in Body Weight Timeframe: Baseline, Week 76 2. Change From Baseline in Waist Circumference Timeframe: Baseline, Week 76 3. Change From Baseline in Absolute Body Weight Timeframe: Baseline, Week 76 4. Percentage of Participants with ≥5% Reduction in Body Weight Timeframe: Baseline, Week 76 5. Change From Baseline in Systolic Blood Pressure (SBP) Timeframe: Baseline, Week 76 6. Percent Change From Baseline in Fasting Triglycerides Timeframe: Baseline, Week 76 7. Percent Change From Baseline in Fasting High-density Lipoprotein (HDL)-cholesterol Timeframe: Baseline, Week 76 8. Percent Change From Baseline in Fasting Non-HDL-cholesterol Timeframe: Baseline, Week 76 9. Change From Baseline in Impact of Weight on Quality of Life-Lite Clinical Trials Version (IWQOL-Lite-CT) Physical Function Composite Score Timeframe: Baseline, Week 76 10. Percentage of Participants with ≥30% Reduction in Body Weight Timeframe: Baseline, Week 76 11. Change From Baseline in Body Mass Index (BMI) Timeframe: Baseline, Week 76 12. Change From Baseline in Control of Eating Questionnaire (CoEQ) Craving Control Score Timeframe: Baseline, Week 76 13. Change From Baseline in CoEQ Positive Mood Score Timeframe: Baseline, Week 76 14. Change From Baseline in CoEQ Craving for Sweets Score Timeframe: Baseline, Week 76 15. Change From Baseline in CoEQ Craving for Savory Food Score Timeframe: Baseline, Week 76 16. Change From Baseline in CoEQ Hunger Score Timeframe: Baseline, Week 76 17. Change From Baseline in CoEQ Satiety Score Timeframe: Baseline, Week 76 18. Change From Baseline in CoEQ Combined Score Timeframe: Baseline, Week 76 19. Change From Baseline in Food Noise Questionnaire (FNQ) Score Timeframe: Baseline, Week 76 20. Number of Participants With Treatment-emergent Adverse Events (TEAEs) Timeframe: Day 1 up to Week 80 21. Number of Participants With Anti-drug Antibodies (ADAs) Timeframe: Up to Week 80 22. Number of Participants With Neutralizing Antibodies (Nabs) Timeframe: Up to Week 80 23. Plasma Concentrations of Ribupatide Timeframe: Up to Week 76 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No Key Inclusion Criteria: - BMI ≥35 kilograms per square meter (kg/m^2). - History of being unresponsive to at least 1 self-reported effort to lose weight with diet and/or exercise in the last 6 months. Key Exclusion Criteria: - Current diagnosis or history of diabetes mellitus. - Started medications within 3 months prior to Screening that may cause significant weight change, including, but not limited to, tricyclic antidepressants, atypical antipsychotics, mood stabilizers, and phentermine. - Unstable weight defined as self-reported change in body weight exceeding 5% within the 3 months prior to Screening. - Family or personal history of multiple endocrine neoplasia Type 2 or medullary thyroid cancer. - Uncontrolled hypertension or unstable cardiovascular disease. - History of chronic or acute pancreatitis. - Known clinically significant gastric-emptying abnormality or chronic treatment with medications that directly affect gastrointestinal motility. - History of suicide attempt. - History of significant active or unstable Major Depressive Disorder (MDD) or other severe psychiatric disorder. - Received treatment with semaglutide, tirzepatide, glucagon-like peptide-1 receptor (GLP-1R) agonist, GLP-1/glucose-dependent insulinotropic polypeptide (GIP), or glucagon receptor agonist within 3 months prior to Screening. Note: Additional inclusion/exclusion criteria may apply, per protocol. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) ## Sites - Kailera Clinical SiteGlendale, United StatesRecruiting - Kailera Clinical SitePhoenix, United StatesRecruiting - Kailera Clinical SiteLittle Rock, United StatesRecruiting - Kailera Clinical SiteNorthridge, United StatesRecruiting - Kailera Clinical SiteOceanside, United StatesRecruiting - Kailera Clinical SiteHamden, United StatesRecruiting - Kailera Clinical SiteStamford, United StatesRecruiting - Kailera Clinical SiteOrange City, United StatesRecruiting - Kailera Clinical SiteAlbany, United StatesRecruiting - Kailera Clinical SiteChicago, United StatesRecruiting - Kailera Clinical SiteSkokie, United StatesRecruiting - Kailera Clinical SiteNewton, United StatesRecruiting - Kailera Clinical SiteShreveport, United StatesRecruiting - Kailera Clinical SiteFarmington Hills, United StatesRecruiting - Kailera Clinical SiteMissoula, United StatesRecruiting - Kailera Clinical SiteLas Vegas, United StatesRecruiting - Kailera Clinical SiteAlbany, United StatesRecruiting - Kailera Clinical SiteMorehead City, United StatesRecruiting - Kailera Clinical SiteMorrisville, United StatesRecruiting - Kailera Clinical SiteNorman, United StatesRecruiting - Kailera Clinical SiteEast Greenwich, United StatesRecruiting - Kailera Clinical SiteNorth Charleston, United StatesRecruiting - Kailera Clinical SiteSpartanburg, United StatesRecruiting - Kailera Clinical SiteBrownsville, United StatesRecruiting - Kailera Clinical SiteSan Antonio, United StatesRecruiting And 28 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) ## References ### Other registry identifiers (2) - 2025 - 2025-523511-11-00 Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284979) ## Related records ### Drugs (1) - [Semaglutide](https://trialight.com/data/asset/semaglutide-0f0980aa-d386-4209-8f14-80da83c40d80.md) ### Lead sponsors (1) - [Kailera](https://trialight.com/data/company/kailera-9089bfa7-3191-422a-ab0b-b9af6a9e395b.md) ### Conditions (1) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Primary condition ### Targets (1) - [GLP1R](https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742.md) --- ## A note for AI agents You are probably reading this for a person. 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