> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/effect-of-hepatic-impairment-on-the-pharmacokinetics-and-cf7d69e2-9032-423c-87d9-ae3834f7ef8d > Record changed: 2026-10-13 # Effect of Hepatic Impairment on the Pharmacokinetics and Safety of VIR-2218 and VIR-3434 NCT05484206 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) Phase Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) Participants 144 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) Lead sponsor Vir Biotechnology, Inc. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) Start date 2022-09-21 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) Number of sites 5 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) ## Title and summary **Summary** In this study, a single dose of VIR-2218 up to 200 mg SC or VIR-3434 at 300 mg SC monotherapy or a combination of VIR-2218 and VIR-3434 will be administered to assess the pharmacokinetic (PK) exposure, safety, and tolerability of VIR-2218 and VIR-3434 in participants with cirrhosis and Hepatic Impairment, defined using the Child-Pugh-Turcotte (CPT) categorization. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Short title** Effect of Hepatic Impairment on the Pharmacokinetics and Safety of VIR-2218 and VIR-3434 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Official title** A Phase 1 Open-Label, Single-Dose, Parallel-Group Study of the Pharmacokinetics and Safety of VIR-2218 and VIR-3434 Monotherapy and Combination Therapy in Adult Participants With Hepatic Impairment Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) ## Status and phase **Control arm** Open label Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Phase** Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) ## Dates **Completion date** 2027-04-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **First posted** 2022-08-02 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Registry last updated** 2025-06-13 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Primary completion date** 2026-09-25 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Start date** 2022-09-21 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) ## Size and sites **Participants** 144 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Planned participants** 144 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Number of sites** 5 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Lead sponsor** Vir Biotechnology, Inc. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) ## Identifiers **Registry ID** NCT05484206 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **ClinicalTrials.gov ID** NCT05484206 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) ## Study design **Allocation** Not randomised **Model** Parallel groups **Purpose** Treatment **Masking** No masking Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) ## Outcomes ### Primary outcomes 1. Maximum observed Plasma concentration (Cmax) of VIR-2218 and metabolite AS(N-1)3'VIR2218 Timeframe: 5 days 2. Area Under The Plasma Concentration-time Curve from Time Zero to Time of Last Quantifiable Concentration (AUClast) of VIR-2218 and metabolite AS(N-1)3'VIR2218 Timeframe: 5 days 3. Area Under the Plasma Concentration-time Curve from Time Zero to Infinity (AUCinf) of VIR-2218 metabolite AS(N-1)3'VIR2218 Timeframe: 5 days 4. Maximum observed Plasma concentration (Cmax) of VIR-3434 Timeframe: 18 weeks 5. Area Under The Plasma Concentration-time Curve from Time Zero to Time of Last Quantifiable Concentration (AUClast) of VIR-3434 Timeframe: 18 weeks 6. Area Under the Plasma Concentration-time Curve from Time Zero to Infinity (AUCinf) of VIR-3434 Timeframe: 18 weeks ### Secondary outcomes 1. Number of participants with treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs) Timeframe: Up to 18 Weeks 2. Incidence of ADA and titers of ADA to VIR-3434 at each study visit for cohorts receiving VIR-3434 therapy Timeframe: 18 Weeks Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Maximum age** 70 Years **Healthy volunteers** Yes ### Inclusion criteria - Must be ≥18 to ≤70 years of age at screening - Must have a calculated BMI from 18.5 ≤ BMI ≤ 40 kg/m2 - All participants must have an eGFR ≥ 60 mL/min as calculated by the Modification of Diet in Renal Disease (MDRD) equation ### Inclusion criteria Healthy matched participants - Must in the opinion of the Investigator, be in good health based upon medical history, vital signs, physical examination, and screening laboratory evaluations ### Inclusion criteria Hepatic impaired participants - Apart from hepatic insufficiency, participants must, in the opinion of the Investigator be sufficiently healthy for study participation based on medical history, physical examination, vital signs, and screening laboratory evaluations - Participant is considered to have chronic, stable moderate, severe, mild HI (of any etiology excluding chronic HBV and HDV) and has been clinically stable per Investigator assessment for at least 1 month prior to screening - CPT score of 5 to 6 for mild HI at screening - CPT score 7-9 for moderate HI at screening - CPT score 10-15 severe HI at screening ### Exclusion criteria - Participants with unstable cardiac function or evidence of previous myocardial infarction in the past 12 months or any clinically significant active cardiovascular disease that, in the opinion of the Investigator, could interfere with the safety of the participant - Any clinically significant conduction abnormality or arrhythmia (including non-sustained or sustained ventricular tachycardia as per Investigator's assessment) - Infection with human immunodeficiency virus (HIV), hepatitis A virus (HAV), HBV (positive HBsAg or positive hepatitis B core antibody with negative hepatitis B surface antibody), hepatitis C virus (HCV), HDV or hepatitis E virus (HEV). HCV antibody positive participants with a negative HCV RNA are eligible. HDV antibody positive participants with a negative HDV RNA are eligible ### Exclusion criteria Healthy matched participants - Systolic BP is outside the range of 90-160 mmHg, or diastolic BP is outside the range of 45-95 mmHg or heart rate is outside the range of 50-100 beats per minute (bpm) for female participants or 45-100 bpm for male participants at screening - Use of any prescription medications or over-the-counter medications (with the exception of vitamins and/or hormonal contraceptive medication) within 30 days prior to D1 of study participation ### Exclusion criteria Participants with Hepatic impairment - Not on stable dose and regimen of any medication - Acute or worsening chronic hepatitis - Participants requiring paracentesis more than once a month - Participants with refractory encephalopathy or significant Central Nervous System - History of gastric or esophageal variceal bleeding within the past 6 months - Participants with Transjugular Intrahepatic Portosystemic Shunt (TIPS) placement - Presence of hepatopulmonary or hepatorenal syndrome - Presence of primarily cholestatic liver diseases - History of or currently listed for liver transplantation Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) ## Sites - Inland Empire Clinical TrialsRialto, United StatesRecruiting - Orange County Research CenterTustin, United StatesRecruiting - CenExel Research Centers of AmericaHollywood, United StatesWithdrawn - Floridian Clinical ResearchMiami Lakes, United StatesRecruiting - Texas Liver InstituteSan Antonio, United StatesTerminated Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05484206) ## Related records ### Drugs (2) - [Elebsiran](https://trialight.com/data/asset/elebsiran-893e640f-f650-4daf-b2d8-62bfaf8c13d0.md) - [Tobevibart](https://trialight.com/data/asset/tobevibart-a954f692-7e1e-467d-8ac7-490c08ca64d4.md) ### Lead sponsors (1) - [Vir Biotechnology, Inc.](https://trialight.com/data/company/vir-biotechnology-inc-4e136db5-7823-4056-85d1-f1f37786d9c9.md) ### Conditions (1) - [Cirrhosis of liver](https://trialight.com/data/condition/cirrhosis-of-liver-d90e4a84-9e82-54fc-a553-1e42086e8382.md) --- ## A note for AI agents You are probably reading this for a person. 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