Clinical Study on TQH2722 Injection Combined With Background Therapy for Seasonal Allergic Rhinitis

NCT07398859
clinicaltrials.gov
Phase
Phase 2
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Recruitment status
Recruiting
clinicaltrials.gov
Participants
300
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Lead sponsor
Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.
clinicaltrials.gov
Start date
2026-03-19
clinicaltrials.gov
Number of sites
30
clinicaltrials.gov

Summary
This study is a multicenter, open-label, Phase II, single-arm clinical trial, with a planned enrollment of 200 to 300 subjects. Its primary objective is to evaluate the safety and efficacy of TQH2722 injection in the treatment of seasonal allergic rhinitis.
clinicaltrials.gov
Short title
Clinical Study on TQH2722 Injection Combined With Background Therapy for Seasonal Allergic Rhinitis
clinicaltrials.gov
Official title
A Multi-center, Open-label, Phase II, Single-arm Clinical Study Evaluating the Safety and Efficacy of TQH2722 Injection Combined With Background Treatment in Subjects With Seasonal Allergic Rhinitis
clinicaltrials.gov

Control arm
Open label
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Registry reports results
No
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Listing at source
Listed
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Recruitment status
Recruiting
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Phase
Phase 2
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Study type
Interventional
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Completion date
2027-03-01
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First posted
2026-02-10
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Registry last updated
2026-03-27
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Primary completion date
2026-11-01
clinicaltrials.gov
Start date
2026-03-19
clinicaltrials.gov

Participants
300
clinicaltrials.gov
Participant count basis
Estimated
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Planned participants
300
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Protocol amendments
0
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Number of sites
30
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Registry sponsor category
Industry
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Lead sponsor
Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.
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Source registry
ClinicalTrials.gov
clinicaltrials.gov

Registry ID
NCT07398859
clinicaltrials.gov
ClinicalTrials.gov ID
NCT07398859
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Registry record
Open registry record
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Allocation
Not applicable
Model
Single group
Purpose
Treatment
Masking
No masking
Sources for study design
clinicaltrials.gov

  1. Number of subjects with incidence of adverse event

    Timeframe: Baseline up to 4 weeks

    Adverse events occurring during treatment.

  1. Number of subjects with incidence of serious adverse event

    Timeframe: Baseline up to 4 weeks

    Serious adverse event occurring during treatment.

  2. Number of subjects with incidence of abnormality check indicators

    Timeframe: Baseline up to 4 weeks

    Number of subjects with incidence of abnormality check indicators: Abnormal examination indicators occurred during treatment.

  3. Retrospective nasal symptom score after treatment for 2 weeks

    Timeframe: Baseline up to 2 weeks

    The average change in the retrospective total nasal symptom score (rTNSS) per day over 2 weeks of treatment compared to baseline. The total score is 0-12 points, with the higher score meaning the more severe symptoms.

  4. Retrospective nasal symptom score after treatment for 4 weeks

    Timeframe: Baseline up to 4 weeks

    The average change in the retrospective total nasal symptom score (rTNSS) per day over 4 weeks of treatment compared to baseline. The total score is 0-12 points, with the higher score meaning the more severe symptoms.

  5. Mean daily morning retrospective total nasal symptom score

    Timeframe: Baseline up to 2 and 4 weeks

    Mean change from baseline in the morning retrospective total nasal symptom score (AM rTNSS) at 2 weeks and 4 weeks of treatment. The total score is 0-12 points, with the higher score meaning the more severe symptoms.

  6. Mean daily retrospective total nasal symptom score at night

    Timeframe: Baseline up to 2 and 4 weeks

    Mean change from baseline in the Post-Medication Reviewed Total Nasal Symptom Score (PMrTNSS) at night per day at 2 weeks and 4 weeks of treatment. The total score is 0-12 points, with the higher score meaning the more severe symptoms.

  7. Total instantaneous nasal symptom score before medication in the morning every day

    Timeframe: Baseline up to 2 and 4 weeks

    Mean change from baseline in instantaneous total nasal symptom score (iTNSS) before medication administration in the morning, for each day during the 2-week and 4-week treatment periods. The total score is 0-12 points, with the higher score meaning the more severe symptoms.

  8. Daily retrospective total nasal symptom score

    Timeframe: Baseline up to 2 and 4 weeks

    Mean percentage change from baseline in daily rTNSS at 2 weeks and 4 weeks of treatment.

  9. Total instantaneous nasal symptom score before medication in the morning every day

    Timeframe: Baseline up to 2 and 4 weeks

    Mean percentage change from baseline in iTNSS before medication administration in the morning, for each day during the 2-week and 4-week treatment periods.

  10. Daily retrospective scoring of individual nasal symptoms

    Timeframe: Baseline up to 2 and 4 weeks

    Mean change from baseline in daily retrospective nasal single symptom scores at 2 weeks and 4 weeks of treatment.

  11. Daily retrospective nasal single symptom score during daytime

    Timeframe: Baseline up to 2 and 4 weeks

    Mean change from baseline in retrospective daytime (AM) nasal individual symptom scores (rhinorrhea, nasal congestion, nasal itch, and sneezing) at 2 weeks and 4 weeks of treatment.

  12. Daily retrospective nasal single symptom score during night

    Timeframe: Baseline up to 2 and 4 weeks

    Mean change from baseline in retrospective nasal individual symptom (rhinorrhea, nasal congestion, nasal itch, and sneezing) scores at night (PM) at 2 weeks and 4 weeks of treatment.

  13. Daily retrospective total score of ocular symptoms

    Timeframe: Baseline up to 2 and 4 weeks

    Mean change from baseline in the retrospective Total Ocular Symptom Score (rTOSS) at 2 weeks or 4 weeks of treatment.

  14. Total score of retrospective ocular symptoms during daytime each day

    Timeframe: Baseline up to 2 and 4 weeks

    Mean change from baseline in the total daytime retrospective ocular symptom score (AM rTOSS) at 2 weeks and 4 weeks of treatment.

  15. Total score of retrospective ocular symptoms each night

    Timeframe: Baseline up to 2 and 4 weeks

    The average change in the retrospective total ocular symptom score (PM rTOSS) at night compared to baseline after 2 weeks and 4 weeks of treatment.

  16. Total score of instantaneous ocular symptoms before medication in the morning every day

    Timeframe: Baseline up to 2 and 4 weeks

    Mean change from baseline in instantaneous total ocular symptom score (iTOSS) before medication administration in the morning, at 2 weeks and 4 weeks of treatment.

  17. Daily retrospective total score of ocular symptoms

    Timeframe: Baseline up to 2 and 4 weeks

    Mean percentage change in total retrospective ocular symptom score from baseline at 2 weeks and 4 weeks of treatment, respectively.

  18. Total score of instantaneous ocular symptoms before medication each morning

    Timeframe: Baseline up to 2 and 4 weeks

    Mean percentage change from baseline in total ocular symptom score immediately before medication administration in the morning, for the 2-week and 4-week treatment periods.

  19. Daily retrospective scoring of individual ocular symptoms

    Timeframe: Baseline up to 2 and 4 weeks

    Mean change in individual ocular symptom scores from baseline to 2 weeks and 4 weeks after treatment, retrospectively assessed daily.

  20. Daily retrospective scoring of individual ocular symptoms during the day

    Timeframe: Baseline up to 2 and 4 weeks

    Mean change from baseline in retrospective ocular symptom scores during daytime (AM) on each day at 2 weeks and 4 weeks of treatment.

  21. Nightly retrospective scoring of individual ocular symptoms

    Timeframe: Baseline up to 2 and 4 weeks

    Mean change from baseline in retrospective ocular symptom scores at night (PM) at 2 weeks and 4 weeks of treatment

  22. Quality of Life Questionnaire Score for Patients with Allergic Rhinitis

    Timeframe: Baseline up to 2 and 4 weeks

    The change in Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores from baseline for patients with allergic rhinitis after 2 weeks and 4 weeks of treatment.

  23. Daily retrospective total score of nasal symptoms

    Timeframe: Baseline up to 2 and 4 weeks

    The area under the curve representing the average change in the retrospective total nasal symptom score (rTNSS) from baseline, calculated for each day during the 2-week and 4-week treatment periods.

  24. Blood eosinophil count and percentage

    Timeframe: Baseline up 12 weeks

    Changes in eosinophil count and percentage from baseline, as well as the percentage of change, at each evaluation visit point.

  25. Serum total immunoglobulin E concentration

    Timeframe: Baseline up 12 weeks

    The changes in serum total immunoglobulin E concentration and the percentage of change from baseline at each evaluation visit point.

And 1 more, listed on the interactive page.

Sources for outcomes
clinicaltrials.gov

Sex
All
Age groups
Adults, Older adults
Minimum age
18 Years
Maximum age
75 Years
Healthy volunteers
No

  • Aged 18-75, with no gender restrictions.
  • Diagnosed with seasonal allergic rhinitis.
  • Positive allergen test result.
  • The subjects have sufficient exposure to pollen during the pollen season.
  • The subject's medical history indicates that the subject had poor control of Seasonal Allergic Rhinitis (SAR) symptoms during the previous pollen season or the subject was dissatisfied with the subjective symptom control.
  • Screen for subjects who have a morning iTNSS score of ≥4 on the day of screening; at baseline visit, have a morning iTNSS score of ≥4, and have an average rTNSS score of ≥4 over the past 6 days.
  • Good compliance during screening/induction period.
  • Subjects with comorbid asthma should have stable medication use before the screening period and have their asthma condition assessed as stable by the investigator or specialist.
  • The subjects voluntarily joined this study, signed the informed consent form, and exhibited good compliance.
  • The subjects and their partners agree to take effective contraceptive measures throughout the entire study period (from the signing of the Informed Consent Form (ICF) to 3 months after the last administration of the trial drug).

  • Any abnormal laboratory test value during the screening period or randomization.
  • Any disease that researchers consider to be unstable and may affect the patient's safety throughout the entire study period, or affect the study results or their interpretation, or hinder the patient's ability to complete the entire study process.
  • Patients with active autoimmune diseases.
  • Known or suspected immunosuppressants.
  • Subjects with active malignant tumors or a history of malignant tumors.
  • Screen for individuals with a history of active tuberculosis within the previous 12 months.
  • During the screening period, there is active hepatitis, or the presence of human immunodeficiency virus antibody (Anti-HIV) positivity, or syphilis treponema antibody (Anti-TP) positivity.
  • Screen for cases diagnosed with helminthic parasitic infections within the previous 6 months, who have not undergone standard treatment or have experienced ineffective standard treatment.
  • Subjects who have received specific medications or undergone any nasal or sinus surgery within the specified timeframe.
  • Intravenous immunoglobulin (IVIG) therapy and/or plasma exchange within 30 days before screening.
  • Screen subjects who have used monoamine oxidase inhibitors within the previous 14 days.
  • Initiate allergen immunotherapy within 3 months prior to screening.
  • Screen for individuals who have received attenuated live vaccines within the previous 4 weeks or plan to receive attenuated live vaccines during the study period.
  • Screen for systemic Chinese herbal preparations used for the treatment of AR with short- or medium-acting systemic glucocorticoids within 4 weeks, or screen for long-acting Systemic Corticosteroids (SCS) received within the previous 6 weeks.
  • Suffering from chronic active or acute infection within 2 weeks before screening or during the screening and import period.
  • Patients with concomitant asthma should be excluded if they meet any of the following conditions: a. forced expiratory volume in one second (FEV1) ≤ 50% of the predicted normal value; b. acute exacerbation of asthma within 90 days prior to screening; c. currently using fluticasone propionate at a daily dose of >1000 μg/day or equivalent doses of other inhaled corticosteroids; d. assessed by the investigator or specialist as having unstable asthma.
  • The subject has a concomitant disease that renders them unable to complete the screening period assessment or evaluate the primary efficacy endpoint.
  • Suffering from malignant and benign tumors in the nasal cavity.
  • Subjects with perennial allergic rhinitis (PAR) who are allergic to pet hair.
  • Unable to use nasal corticosteroid sprays or antihistamines.
  • Have a history of systemic allergy to any biological agents.
  • Women who are pregnant or breastfeeding.
  • Individuals who abuse alcohol, use drugs, and have known drug dependency.
  • History of major organ transplantation or hematopoietic stem cell/bone marrow transplantation.
  • According to the researcher's judgment, there are any medical or psychiatric symptoms that may put the subjects at risk, interfere with their participation in the study, or interfere with the interpretation of the study results.
  • The forced expiratory volume in one second (FEV1) of the subject is less than or equal to 50% of the predicted normal value.
  • Other reasons why the researcher believes it is inappropriate to participate in this trial.
Sources for eligibility
clinicaltrials.gov

  • Peking University First HospitalBeijing, ChinaNot yet recruiting
  • Peking University People's HospitalBeijing, ChinaNot yet recruiting
  • Peking University Third HospitalBeijing, ChinaRecruiting
  • The First Affiliated Hospital of Chongqing Medical UniversityChongqing, ChinaRecruiting
  • Hebei University Affiliated HospitalBaoding, ChinaNot yet recruiting
  • Cangzhou Central HospitalCangzhou, ChinaNot yet recruiting
  • Hebei PetroChina Central HospitalLangfang, ChinaNot yet recruiting
  • Hebei Provincial People's HospitalShijiazhuang, ChinaNot yet recruiting
  • Hebei Medical University Third HospitalShijiazhuang, ChinaNot yet recruiting
  • The First Affiliated Hospital of Hebei North UniversityZhangjiakou, ChinaNot yet recruiting
  • Henan Provincial People's HospitalZhengzhou, ChinaNot yet recruiting
  • The Central Hospital of WuhanWuhan, ChinaNot yet recruiting
  • Union Hospital, Tongji Medical College, Huazhong University of science and technologyWuhan, ChinaNot yet recruiting
  • Tongji Hospital of Tongji medical college of HUSTWuhan, ChinaNot yet recruiting
  • Zhongnan Hospital of Wuhan UniversityWuhan, ChinaNot yet recruiting
  • The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an, ChinaNot yet recruiting
  • The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an, ChinaNot yet recruiting
  • Yan'an University Xianyang HospitalXi'an, ChinaNot yet recruiting
  • Shandong Second Provincial General HospitalJinan, ChinaNot yet recruiting
  • Qilu Hospital of Shandong UniversityJinan, ChinaNot yet recruiting
  • Yantai Yuhuangding HospitalYantai, ChinaNot yet recruiting
  • Zibo Central HospitalZibo, ChinaNot yet recruiting
  • Shanxi Bethune HospitalTaiyuan, ChinaRecruiting
  • Hospital of Chengdu University of Traditional Chinese MedicineChengdu, ChinaNot yet recruiting
  • Second People's Hospital of ChengduChengdu, ChinaNot yet recruiting

And 5 more, listed on the interactive page.

Sources for sites
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Related records

Drugs (1)

Lead sponsors (1)

Conditions (2)