> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/assessing-the-impact-of-muvalaplin-on-major-cardiovascular-e88d9dae-5619-485f-a493-5e205b266e64 > Record changed: 2026-10-13 # Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a) NCT07157774 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) Participants 10,450 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) Start date 2025-09-02 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) Number of sites 801 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) ## Title and summary **Summary** The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Acronym** MOVE-Lp(a) Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Short title** Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a) Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Official title** A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effect of Muvalaplin on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) Who Have Had a Prior Atherosclerotic Cardiovascular Event or Are at Risk for a First Atherosclerotic Cardiovascular Event Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) ## Dates **Completion date** 2031-03-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **First posted** 2025-09-05 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Registry last updated** 2026-08-21 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Primary completion date** 2031-03-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Start date** 2025-09-02 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) ## Size and sites **Participants** 10,450 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Planned participants** 10,450 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Number of sites** 801 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) ## Identifiers **Registry ID** NCT07157774 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **ClinicalTrials.gov ID** NCT07157774 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) ## Outcomes ### Primary outcomes 1. Time to First Occurrence of Any Component of the Major Adverse Cardiac Event (MACE)-4 Composite Endpoint Timeframe: Baseline up to End of Study (About 5.25 Years) Time to first event in a MACE-4 composite endpoint, comprised of cardiovascular death, nonfatal myocardial infarction, nonfatal ischemic stroke, and urgent coronary revascularization. ### Secondary outcomes 1. Percent Change from Baseline in Lipoprotein(a) (Lp(a)) at Week 4 Timeframe: Baseline, Week 4 2. Time to First Occurrence of Any Component of the MACE-3 Composite Endpoint Timeframe: Baseline up to End of Study (About 5.25 Years) 3. Time to First Occurrence of Any Component of the Modified MACE-3 Composite Endpoint Timeframe: Baseline up to End of Study (About 5.25 Years) 4. Time to First Occurrence of Any Component of the Coronary MACE-3 Composite Endpoint Timeframe: Baseline up to End of Study (About 5.25 Years) 5. Time to First Occurrence of Any Component of MACE-3 + Major Adverse Limb Event (MALE) Composite Endpoint Timeframe: Baseline up to End of Study (About 5.25 Years) 6. Time to Occurrence of All-Cause Mortality Timeframe: Baseline up to End of Study (About 5.25 Years) 7. Time to First Occurrence of Each Individual Component of the MACE-4 Composite Endpoint Timeframe: Baseline up to End of Study (About 5.25 Years) 8. Change from Baseline to Each Annual Visit for Health-Care Resource Utilization (HCRU) Timeframe: Baseline up to End of Study (About 5.25 Years) 9. Pharmacokinetics (PK): Trough Concentration at Steady State (C-trough, ss) of Muvalaplin Timeframe: Predose through Week 96 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Have Lp(a) ≥175 nanomoles per liter (nmol/L) - Meet one of the following criteria: - Have had a prior atherosclerotic cardiovascular disease (ASCVD) event (such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body) within 10 years prior to screening - Are at risk for a first ASCVD event, defined as one or more of the following: - Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without a history of ASCVD event - A high coronary artery calcium (CAC) score - Reduced kidney function with diabetes - Combination(s) of high risk factors ### Exclusion criteria - Have experienced a major cardiovascular event or surgery, such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body, within 90 days prior to screening or occurring between screening and randomization - Are planning or expected to undergo a procedure to restore blood flow in the arteries or a major heart surgery during the study - Have uncontrolled high blood pressure - Have New York Heart Association (NYHA) class III or IV heart failure - Have undergone a procedure to remove cholesterol from the blood within 90 days of screening, or have a planned procedure during the study - Have severe kidney impairment - Have had cancer within 5 years prior to screening Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) ## Sites - Birmingham Clinical ResearchBirmingham, United StatesNot yet recruiting - Smiths Medical CenterApache Junction, United StatesNot yet recruiting - Phoenix Medical TrialsGilbert, United StatesNot yet recruiting - Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLCGilbert, United StatesRecruiting - Onyx Clinical ResearchPhoenix, United StatesRecruiting - Clinical Research Institute of Arizona (CRI) - Sun City WestSun City West, United StatesRecruiting - Southwest Kidney Institute - SurpriseSurprise, United StatesRecruiting - Pima HeartTucson, United StatesRecruiting - Eclipse Clinical ResearchTucson, United StatesNot yet recruiting - National Heart InstituteBeverly Hills, United StatesRecruiting - John Muir Medical Center - Concord CampusConcord, United StatesRecruiting - Neighborhood Healthcare Institute of HealthEscondido, United StatesRecruiting - Ark Clinical Research - Fountain ValleyFountain Valley, United StatesRecruiting - Thrive Clinical Research GroupGlendora, United StatesNot yet recruiting - Care Access - Huntington BeachHuntington Beach, United StatesRecruiting - Scripps Whittier Diabetes InstituteLa Jolla, United StatesNot yet recruiting - The Cardiovascular CenterRedding, United StatesRecruiting - FOMAT Medical Research - Santa MariaSanta Maria, United StatesNot yet recruiting - Integrated Clinical ResearchSherman Oaks, United StatesNot yet recruiting - UCLA South Bay EndocrinologyTorrance, United StatesRecruiting - University of Colorado Anschutz Medical CampusAurora, United StatesRecruiting - Legacy Clinical TrialsColorado Springs, United StatesRecruiting - OptumCare Clinical Trials, LLCGolden, United StatesCompleted - Cardiology Associates of Fairfield County, P.C.Stamford, United StatesRecruiting - Chase Medical Research, LLCWaterbury, United StatesRecruiting And 776 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) ## References - Related resource (trials.lilly.com) Source: [trials.lilly.com](https://trials.lilly.com/en-US/trial/649436) ### Other registry identifiers (3) - 2025 - 2025-521067-13-00 - J2O-MC-EKBG Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07157774) ## Related records ### Drugs (1) - [Muvalaplin](https://trialight.com/data/asset/muvalaplin-21088c29-3f3d-47df-8540-cf6e2ae2beff.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (3) - [Atherosclerosis](https://trialight.com/data/condition/atherosclerosis-5dab64e9-1fd4-5dd2-90c2-ce84935652d1.md) - [Atherosclerotic cardiovascular disease](https://trialight.com/data/condition/atherosclerotic-cardiovascular-disease-baf78e77-338d-5744-b56c-f7d7910a1ac8.md) - [Multisystem inflammatory syndrome in children and adults](https://trialight.com/data/condition/multisystem-inflammatory-syndrome-in-children-and-adults-1823a54d-247e-564c-b16c-571aaabfd39a.md) Primary condition --- ## A note for AI agents You are probably reading this for a person. 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