> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/application-of-transversus-abdominus-plain-block-local-0a4ed096-d53b-46c2-b67c-20e6e0581625 > Record changed: 2026-10-13 # Application of Transversus Abdominus Plain Block, Local Subcutaneous Injection and IV Nalbuphine NCT05276206 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) Phase Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) Participants 400 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) Lead sponsor Egymedicalpedia Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) Start date 2022-03-07 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) Number of sites 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) ## Title and summary **Summary** Approximately 1 in 5 women who undergo CS will experience severe acute postoperative pain. The severity of pain in the acute postoperative period is a significant predictor for the development of chronic pain, which occurs in 9.2%-18% of women who undergo CS. Furthermore, severe acute post-cesarean pain triples a woman's risk of developing postpartum depression and negatively affects breastfeeding and infant care. For these reasons, it is imperative to provide adequate postoperative analgesia in this patient population Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Short title** Application of Transversus Abdominus Plain Block, Local Subcutaneous Injection and IV Nalbuphine Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Official title** Comparative Study Between Transversus Abdominus Plain Block, Local Subcutaneous Injection in the Wound, and Intravenous Nalbuphine in Decreasing Postoperative Pain in Cesarean Section Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) ## Status and phase **Control arm** Active comparator Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Phase** Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) ## Dates **Completion date** 2022-04-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **First posted** 2022-03-11 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Registry last updated** 2023-07-10 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Primary completion date** 2022-03-20 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Start date** 2022-03-07 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) ## Size and sites **Actual participants** 400 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Participants** 400 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Number of sites** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Lead sponsor** Egymedicalpedia Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) ## Identifiers **Registry ID** NCT05276206 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **ClinicalTrials.gov ID** NCT05276206 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) ## Study design **Allocation** Randomised **Model** Factorial **Purpose** Treatment **Masking** Quadruple masking **Masked roles** Participants, Care providers, Investigators, Outcome assessors Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) ## Outcomes ### Primary outcomes 1. Post Operative Pain Timeframe: 2 hours after the Cesarean Section till the pain relief The pain level of the cases is evaluated by means of the digital pain (numeric rating) scale from 0 to 10 in which 0 means "no pain" and 10 means "the worst pain" as well as the duration of pain relief Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) ## Eligibility **Sex** Female **Age groups** Adults **Minimum age** 20 Years **Maximum age** 35 Years **Healthy volunteers** Yes ### Inclusion criteria - Pregnant women aged 20-35 years - Gestational age between 37-40 weeks - Pregnant women undergoing elective cesarean section - Medically free - Singleton pregnancy ### Exclusion criteria - Emergency cesarean section - Diabetic - Hypertensive - Severe anemia - Multiple pregnancy - Complication during section Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) ## Sites - Al-Azhar UniversityCairo, Egypt Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05276206) ## Related records ### Drugs (2) - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) - [Poloxalene](https://trialight.com/data/asset/poloxalene-212f99fb-c980-4fa4-9047-c10b97dbffe6.md) ### Lead sponsors (1) - [Egymedicalpedia](https://trialight.com/data/company/egymedicalpedia-acb05d45-26ff-47dc-abf4-9f76a069c322.md) ### Targets (4) - [FAAH](https://trialight.com/data/target/faah-8bd94be5-4dfa-5292-b0c7-abc43b2d247f.md) - [PTGS1](https://trialight.com/data/target/ptgs1-5707ce48-8ccd-5bd5-8c18-9c64cacc2fef.md) - [PTGS2](https://trialight.com/data/target/ptgs2-85dbd9a5-4609-5423-b863-90d0a825b213.md) - [TRPV1](https://trialight.com/data/target/trpv1-ca64e282-0693-5882-a5bc-8b93d8310d3a.md) --- ## A note for AI agents You are probably reading this for a person. 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