> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/amaze-9-a-research-study-investigating-how-well-zenagamtide-8fd776c5-b729-4210-a6fa-59a883d8572c > Record changed: 2026-11-04 # AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight NCT07720271 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) Participants 950 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) Lead sponsor Novo Nordisk A/S Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) Start date 2026-08-31 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) Number of sites 41 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) ## Title and summary **Summary** The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Acronym** AMAZE 9 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Short title** AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Official title** Efficacy and Safety of Once-daily Oral Zenagamtide in Participants With Obesity (AMAZE 9) Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) ## Dates **Completion date** 2028-08-22 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **First posted** 2026-07-22 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Registry last updated** 2026-09-28 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Primary completion date** 2028-06-27 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Start date** 2026-08-31 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) ## Size and sites **Participants** 950 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Planned participants** 950 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Number of sites** 41 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Lead sponsor** Novo Nordisk A/S Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) ## Identifiers **Registry ID** NCT07720271 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **ClinicalTrials.gov ID** NCT07720271 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Quadruple masking **Masking description** Sponsor staff involved in the clinical trial is masked according to company standard procedures **Masked roles** Participants, Care providers, Investigators, Outcome assessors Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) ## Outcomes ### Primary outcomes 1. Relative change in body weight Timeframe: From baseline (week 0) to (week 76) Measured as percentage (%) change in body weight. ### Secondary outcomes 1. Change in waist circumference Timeframe: From baseline (week 0) to (week 76) Measured as centimetre (cm) 2. Change in systolic blood pressure (SBP) Timeframe: From baseline (week 0) to (week 76) Measured as millimetre of mercury (mmHg). Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Male or female (sex at birth). - Age 18 and older (both inclusive) at time of signing the informed consent. ### Exclusion criteria - Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening. - History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. - Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) ## Sites - Pinnacle Research Group LLCAnniston, United StatesRecruiting - Univ of Alabama BirminghamBirmingham, United StatesRecruiting - Chambliss Clinical Trials LLCMontgomery, United StatesRecruiting - Providence Medical FoundationFullerton, United StatesRecruiting - Torrance Clinical Research Institute, Inc.Lomita, United StatesRecruiting - Diablo Clinical Research, Inc.Walnut Creek, United StatesRecruiting - Univ of Colorado at DenverAurora, United StatesRecruiting - Brain Matters ResearchDelray Beach, United StatesRecruiting - Northeast Research InstituteFleming Island, United StatesRecruiting - Miguel Rebollar PAHialeah, United StatesRecruiting - Jacksonville Ctr Clin ResJacksonville, United StatesRecruiting - South Broward Research LLCMiramar, United StatesRecruiting - Clinical Neuroscience SolutionOrlando, United StatesRecruiting - Florida Institute for Clinical Research, LLCOrlando, United StatesRecruiting - Oviedo Medical Research, LLCOviedo, United StatesRecruiting - Hope Clin Res & WellnessConyers, United StatesRecruiting - East West Medical Research Institute\_HonoluluHonolulu, United StatesRecruiting - Great Lakes Clinical TrialsChicago, United StatesRecruiting - Clinical Investigation Spec GurneeGurnee, United StatesRecruiting - Endeavor HealthSkokie, United StatesRecruiting - Evanston Premier Hlthcr ResSkokie, United StatesRecruiting - Midwest Inst For Clin ResIndianapolis, United StatesNot yet recruiting - Northern Pines Hlth Ctr, PCBuckley, United StatesRecruiting - StudyMetrix Research LLCCity of Saint Peters, United StatesRecruiting - Palm Research Center Inc.Las Vegas, United StatesRecruiting And 16 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) ## References ### Other registry identifiers - U1111-1313-7267 Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720271) ## Related records ### Drugs (1) - [Zenagamtide](https://trialight.com/data/asset/zenagamtide-1657e00d-b72c-5541-9936-13b091a52ddc.md) ### Lead sponsors (1) - [Novo Nordisk A/S](https://trialight.com/data/company/novo-nordisk-a-s-35a80f1a-9ef6-4057-99c1-6ab497939195.md) ### Conditions (1) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) --- ## A note for AI agents You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them. - Cite this page with its date. 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