> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-trial-of-shr-a2102-with-other-antitumor-therapies-in-32a3d640-e015-4bd7-b00a-473a7d4488b7 > Record changed: 2026-10-13 # A Trial of SHR-A2102 With Other Antitumor Therapies in Advanced Solid Tumors NCT06895928 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) Phase Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) Participants 400 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) Lead sponsor Shanghai Hengrui Pharmaceutical Co., Ltd. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) Start date 2025-03-28 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) Number of sites 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) ## Title and summary **Summary** The study is being conducted to evaluate the safety, tolerability and efficacy of SHR-A2102 with other antitumor therapies in advanced solid tumors to explore the reasonable dosage, safety and efficacy of SHR-A2102 for advanced solid tumors. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Short title** A Trial of SHR-A2102 With Other Antitumor Therapies in Advanced Solid Tumors Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Official title** A Phase II, Multicenter, Open-Label Study of Safety, Tolerability and Efficacy of SHR-A2102 for Injection in Combination With Other Antitumor Therapies in Patients With Advanced Solid Tumors Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) ## Status and phase **Control arm** Open label Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Phase** Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) ## Dates **Completion date** 2028-12-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **First posted** 2025-03-26 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Registry last updated** 2025-04-22 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Primary completion date** 2028-12-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Start date** 2025-03-28 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) ## Size and sites **Participants** 400 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Planned participants** 400 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Number of sites** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) ## Sponsor and oversight **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Lead sponsor** Shanghai Hengrui Pharmaceutical Co., Ltd. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) ## Identifiers **Registry ID** NCT06895928 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **ClinicalTrials.gov ID** NCT06895928 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) ## Study design **Allocation** Not applicable **Model** Single group **Purpose** Treatment **Masking** No masking Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) ## Outcomes ### Primary outcomes 1. Adverse events (AEs) Timeframe: From day 1 to 90 days after the last dose. 2. Serious adverse events (SAEs) Timeframe: From day 1 to 90 days after the last dose. 3. Objective response rate (ORR) Timeframe: About 2 years. ### Secondary outcomes 1. Disease control rate (DCR) Timeframe: About 2 years. 2. Duration of response (DOR) Timeframe: About 2 years. 3. Progression free survival (PFS) Timeframe: About 2 years. 4. Overall survival (OS) Timeframe: About 2 years. Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Maximum age** 70 Years **Healthy volunteers** No ### Inclusion criteria 1. The age of signing the informed consent is 18 -70 years, regardless of gender. 2. At least one measurable lesion according to RECIST v1.1 criteria. 3. The ECOG score is 0 or 1. 4. Expected survival ≥12 weeks. 5. Good level of organ function. 6. Have the ability to give informed consent and to comply with the treatment plan. 7. Male subjects whose partners are women of childbearing age and female subjects who are fertile are required to use highly effective contraceptive methods. ### Exclusion criteria 1. Inadequately treated central nervous system metastases or the presence of uncontrolled or symptomatic active central nervous system metastases. 2. Spinal cord compression not cured by surgery and/or radiotherapy. 3. Subjects with uncontrolled tumor-related pain. 4. Received antitumor therapy within 4 weeks before the start of the study. 5. Subjects with severe cardiovascular and cerebrovascular disease. 6. History of immunodeficiency, including a positive HIV test. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) ## Sites - Shanxi Cancer hospitalTaiyuan, ChinaRecruiting Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06895928) ## Related records ### Drugs (4) - [Adebrelimab](https://trialight.com/data/asset/adebrelimab-047820dd-1777-483d-90ab-dd5fc86f78f6.md) - [Apilimod mesylate](https://trialight.com/data/asset/apilimod-mesylate-2a01ca48-f560-4231-b26b-aa9fb9f4dd3e.md) - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) - [Osimertinib mesylate](https://trialight.com/data/asset/osimertinib-mesylate-1174023a-e2bd-4773-ad07-2566cbd51026.md) ### Lead sponsors (1) - [Shanghai Hengrui Pharmaceutical Co., Ltd.](https://trialight.com/data/company/shanghai-hengrui-pharmaceutical-co-ltd-99e79134-0170-4beb-ba13-f33c49843c3e.md) ### Targets (4) - [CD274](https://trialight.com/data/target/cd274-67467e37-9325-584a-be55-e3ef69f22b4c.md) - [EGFR](https://trialight.com/data/target/egfr-5c134fbe-bf90-5792-81e3-542be53c2be7.md) - [PIKFYVE](https://trialight.com/data/target/pikfyve-5d7458d7-14ab-5816-be7c-38b4d9de4ff7.md) - [VEGFA](https://trialight.com/data/target/vegfa-d5a98392-6ee9-5b71-b7a2-9a73ce1575d2.md) --- ## A note for AI agents You are probably reading this for a person. 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