> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-to-investigate-weight-management-with-ly3841136-and-c25d599f-0cc7-4dd1-b5dd-654c6552f677 > Record changed: 2026-10-13 # A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 Diabetes NCT06603571 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) Phase Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) Recruitment status Active, not recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) Participants 367 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) Start date 2024-09-20 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) Number of sites 52 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) ## Title and summary **Summary** The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to investigate the safety and efficacy of LY3841136 for chronic weight management alone or in combination with Tirzepatide across a wide dose range in participants with Type 2 Diabetes. Participation in the study will last about 64 weeks. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Short title** A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 Diabetes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Official title** A Phase 2, Parallel-Group, Double-Blind, Placebo-Controlled Study to Investigate Weight Management With LY3841136 and Tirzepatide, Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 Diabetes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Recruitment status** Active, not recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Phase** Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) ## Dates **Completion date** 2026-08-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **First posted** 2024-09-19 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Registry last updated** 2026-07-17 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Primary completion date** 2026-07-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Start date** 2024-09-20 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) ## Size and sites **Actual participants** 367 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Participants** 367 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Number of sites** 52 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) ## Identifiers **Registry ID** NCT06603571 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **ClinicalTrials.gov ID** NCT06603571 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) ## Outcomes ### Primary outcomes 1. Percent Change from Baseline in Body Weight Timeframe: Baseline, Week 48 ### Secondary outcomes 1. Change from Baseline in Body Weight Timeframe: Baseline, Week 48 2. Percentage of Participants Who Achieve ≥5% Body Weight Reduction Timeframe: Week 48 3. Percentage of Participants Who Achieve ≥10% Body Weight Reduction Timeframe: Week 48 4. Change from baseline in Hemoglobin A1c (HbA1c) Timeframe: Baseline, Week 48 5. Pharmacokinetics (PK): Area Under the Curve (AUC) of LY3841136 Timeframe: Baseline, Week 48 6. PK: Maximum Concentration (Cmax) of LY3841136 Timeframe: Baseline, Week 48 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Maximum age** 75 Years **Healthy volunteers** No ### Inclusion criteria W8M-MC-LAA2 - Have a Body Mass Index (BMI) of ≥27 kilograms per square meter (kg/m²) - Have Type 2 Diabetes - Have a HbA1c ≥7.0 % (53 millimoles/mole (mmol/mol)) to ≤10.5% (91 mmol/mol) and treated with diet and exercise alone or with a stable dose of metformin (and not more than the locally approved dose) with or without a sodium-glucose cotransporter 2 (SGLT2) inhibitor for at least 3 months prior to screening W8M-MC-CWMM: - Have had a stable body weight for the 3 months prior to randomization (<5% body weight gain and/or loss) ### Exclusion criteria W8M-MC-LAA2 - Have a history of severe hypoglycemia or hypoglycemia unawareness within the last 6 months prior to screening - Have an on-going or history of bradyarrhythmia and/or sinus bradycardia - Have an elevated resting pulse rate (mean >100 beats per minute (bpm)) or reduced resting pulse rate (mean <60 bpm) at screening - Have any of the following cardiovascular conditions within 6 months prior to screening: - acute myocardial infarction - cerebrovascular accident (stroke) - unstable angina, or - hospitalization due to congestive heart failure - Have renal impairment measured as estimated glomerular filtration rate (eGFR) <45 milliliters per minute (mL/min)/1.73 m2 - Have a history of acute or chronic pancreatitis - Have fasting triglycerides >500 milligrams per deciliter (mg/dL) (5.7 mmol/L) at screening - All concomitant medications should be at a stable dose for at least 3 months prior to screening W8M-MC-CWMM - Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening. - Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma. - Have poorly controlled hypertension. - Have a history of symptomatic gallbladder disease within the past 2 years - Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease. - Have a lifetime history of suicide attempts. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) ## Sites - The Institute for Liver Health II dba Arizona Clinical Trials - MesaChandler, United States - HOPE Research InstitutePhoenix, United States - Headlands Research - ScottsdaleScottsdale, United States - The Institute for Liver Health II dba Arizona Liver Health-TucsonTucson, United States - NorCal Medical Research, IncGreenbrae, United States - Velocity Clinical Research, Huntington ParkHuntington Park, United States - Peninsula Research AssociatesRolling Hills Estates, United States - Diablo Clinical Research, Inc.Walnut Creek, United States - Stamford Therapeutics ConsortiumStamford, United States - Northeast Research Institute (NERI)Fleming Island, United States - Indago Research & Health Center, IncHialeah, United States - New Horizon Research CenterMiami, United States - Suncoast Clinical Research, Inc.New Port Richey, United States - Charter Research - Winter ParkOrlando, United States - Charter Research - Lady LakeThe Villages, United States - Medical Research PartnersAmmon, United States - Great Lakes Clinical Trials - AndersonvilleChicago, United States - Great Lakes Clinical Trials - RavenswoodChicago, United States - NorthShore University Health SystemSkokie, United States - Iowa Diabetes and Endocrinology Research CenterWest Des Moines, United States - Cotton O'Neil Diabetes & EndocrinologyTopeka, United States - KnownwellNeedham, United States - Lucida Clinical TrialsNew Bedford, United States - Headlands Research - DetroitSouthfield, United States - Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionTroy, United States And 27 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) ## References - Related resource (trials.lilly.com) Source: [trials.lilly.com](https://trials.lilly.com/en-US/trial/533180) ### Other registry identifiers - W8M-MC-LAA2 Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06603571) ## Related records ### Drugs (2) - [Eloralintide](https://trialight.com/data/asset/eloralintide-ccf70d16-4bb8-42b3-b3e3-491d8fbd44a8.md) - [Tirzepatide](https://trialight.com/data/asset/tirzepatide-eed85871-eb9c-4712-9102-badfdd99a720.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (2) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Primary condition - [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) ### Targets (2) - [GIPR](https://trialight.com/data/target/gipr-5b65dd73-9875-5aca-be7a-5469a7290f0c.md) - [GLP1R](https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742.md) --- ## A note for AI agents You are probably reading this for a person. 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