> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-to-investigate-weight-management-with-bimagrumab-26f0de00-2523-4552-8938-bca37397d2e8 > Record changed: 2026-11-04 # A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Obesity or Overweight NCT06643728 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) Phase Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) Recruitment status Active, not recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) Participants 252 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) Start date 2024-10-21 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) Number of sites 12 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) ## Title and summary **Summary** The main purpose of this study is to evaluate the efficacy and safety of Bimagrumab and Tirzepatide, alone or in combination, in adults with obesity or overweight, with at least one obesity related comorbidity, without Type 2 Diabetes. The study will last about 70 weeks. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Short title** A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Obesity or Overweight Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Official title** A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study of Bimagrumab and Tirzepatide, Alone or in Combination, to Investigate the Efficacy and Safety in Adult Participants With Obesity or Overweight Without Type 2 Diabetes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Recruitment status** Active, not recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Phase** Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) ## Dates **Completion date** 2027-01-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **First posted** 2024-10-16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Registry last updated** 2026-05-26 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Primary completion date** 2026-01-16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Start date** 2024-10-21 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) ## Size and sites **Actual participants** 252 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Participants** 252 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Protocol amendments** 5 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Number of sites** 12 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) ## Identifiers **Registry ID** NCT06643728 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **ClinicalTrials.gov ID** NCT06643728 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) ## Outcomes ### Primary outcomes 1. Percent Change from Baseline in Body Weight Timeframe: Baseline, Week 24 ### Secondary outcomes 1. Percent Change from Baseline in Total Body Fat Mass by Dual-Energy X-Ray Absorptiometry (DXA) Timeframe: Baseline, Week 24, Week 48 2. Change from Baseline in Body Weight Timeframe: Baseline, Week 24, Week 48 3. Percentage of Participants Achieving ≥5% Body Weight Reduction Timeframe: Baseline, Week 24, Week 48 4. Percentage of Participants Achieving ≥10% Body Weight Reduction Timeframe: Baseline, Week 24, Week 48 5. Percentage of Participants Achieving ≥15% Body Weight Reduction Timeframe: Baseline, Week 24, Week 48 6. Change from Baseline in Waist Circumference Timeframe: Baseline, Week 24, Week 48 7. Change from Baseline in Body Mass Index (BMI) Timeframe: Baseline, Week 24, Week 48 8. Change from Baseline in Waist-to-Height Ratio (WHtR) Timeframe: Baseline, Week 24, Week 48 9. Percent Change from Baseline in Visceral Adipose Tissue (VAT) Timeframe: Baseline, Week 24, Week 48 10. Percent Change from Baseline in Total Body Lean Mass by DXA Timeframe: Baseline, Week 24, Week 48 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Maximum age** 75 Years **Healthy volunteers** No ### Inclusion criteria - Have a BMI of - ≥30 kilograms per square meter (kg/m2) or - ≥27 kg/m2 and <30 kg/m2, with at least one of the following weight-related comorbidities: - Hypertension - Dyslipidemia - Cardiovascular disease - Obstructive sleep apnea - Have had a stable body weight for the 3 months prior to randomization (<5% body weight gain and/or loss) ### Exclusion criteria - Have a prior or planned surgical treatment for obesity - Have at least one laboratory value suggestive of diabetes during screening - Use of metformin, or any other glucose-lowering medications - Have Type 1 Diabetes, latent autoimmune diabetes, been diagnosed with any form of diabetes mellitus except for a prior diagnosis of gestational diabetes mellitus, or history of ketoacidosis or hyperosmolar coma - Have poorly controlled hypertension - Have any of the following cardiovascular conditions within 3 months prior to screening: - acute myocardial infarction - cerebrovascular accident (stroke) - unstable angina, or - hospitalization due to congestive heart failure - Have ongoing or a history of frequent intermittent or chronic tachyarrhythmia syndromes - Have ongoing or a history of bradyarrhythmias other than sinus bradycardia - Have a history of New York Heart Association (NYHA) Functional Classification III or IV congestive heart failure - Have a history of symptomatic gallbladder disease within the past 2 years - Have signs and symptoms of any liver disease - Have a disease or condition known to cause gastrointestinal malabsorption or a known clinically significant gastric emptying abnormality - Have a history of acute or chronic pancreatitis - Have renal impairment, measured as estimated glomerular filtration rate <30 mL/minute/1.73 m2 - Currently taking or have taken medications that may cause significant weight gain or promote weight loss within 3 months prior to screening Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) ## Sites - Pinnacle Research Group, LLCAnniston, United States - Central Research AssociatesBirmingham, United States - Diablo Clinical Research, Inc.Walnut Creek, United States - Clinical Neuroscience Solutions, Inc. dba CNS HealthcareJacksonville, United States - Altus ResearchLake Worth, United States - Suncoast Research GroupMiami, United States - East-West Medical Research InstituteHonolulu, United States - Great Lakes Clinical Trials - RavenswoodChicago, United States - SKY Integrative Medical Center/SKYCRNGRidgeland, United States - Keystone Clinical StudiesPlymouth Meeting, United States - Eastside Research AssociatesRedmond, United States - Rainier Clinical Research CenterRenton, United States Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) ## References - Related resource (trials.lilly.com) Source: [trials.lilly.com](https://trials.lilly.com/en-US/trial/546217) ### Other registry identifiers - J4Z-MC-GIDF Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06643728) ## Related records ### Drugs (2) - [Bimagrumab](https://trialight.com/data/asset/bimagrumab-0a25ca88-023e-46fb-a721-cf5c435758d7.md) - [Tirzepatide](https://trialight.com/data/asset/tirzepatide-eed85871-eb9c-4712-9102-badfdd99a720.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (2) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Primary condition - [Platelet-type bleeding disorder 10](https://trialight.com/data/condition/platelet-type-bleeding-disorder-10-b7903473-b818-53b2-9e79-42f6a25d3424.md) ### Targets (4) - [ACVR2A](https://trialight.com/data/target/acvr2a-49c643d3-7803-59e6-9f53-b13ec1467b7a.md) - [ACVR2B](https://trialight.com/data/target/acvr2b-cb4a236d-550a-5b3c-be5a-939d03d0fc1e.md) - [GIPR](https://trialight.com/data/target/gipr-5b65dd73-9875-5aca-be7a-5469a7290f0c.md) - [GLP1R](https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742.md) --- ## A note for AI agents You are probably reading this for a person. 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