> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-to-find-out-if-the-study-drug-elecoglipron-helps-ee348bb6-c54f-42ff-b1ff-d505620eae98 > Record changed: 2026-10-13 # A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus NCT07662213 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) Participants 1,200 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) Lead sponsor AstraZeneca Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) Start date 2026-07-06 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) Number of sites 201 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) ## Title and summary **Summary** The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with oral semaglutide in adults with T2DM and increased cardiovascular risk that is inadequately managed alone or on stable treatment with other background glucose-lowering medication(s). Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Acronym** Eluminate-2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Short title** A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Official title** A Randomized, Open-label, Parallel-group Phase III Study to Evaluate the Efficacy, Safety, and Tolerability of Elecoglipron Compared With Oral Semaglutide in Adults With Type 2 Diabetes Mellitus (Eluminate-2) Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) ## Status and phase **Control arm** Active comparator Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) ## Dates **Completion date** 2028-05-23 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **First posted** 2026-06-23 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Registry last updated** 2026-07-14 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Primary completion date** 2028-05-23 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Start date** 2026-07-06 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) ## Size and sites **Participants** 1,200 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Planned participants** 1,200 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Number of sites** 201 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Lead sponsor** AstraZeneca Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) ## Identifiers **Registry ID** NCT07662213 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **ClinicalTrials.gov ID** NCT07662213 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** No masking Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) ## Outcomes ### Primary outcomes 1. Change from baseline in Hemoglobin A1c (HbA1c) Timeframe: Baseline to Week 52 ### Secondary outcomes 1. Percent change from baseline to Week 52 in body weight Timeframe: Baseline to Week 52 2. Change from baseline to Week 52 in body weight (kg) Timeframe: Baseline to Week 52 3. Achieved ≥ 5% weight loss from baseline at Week 52 and achieved HbA1c < 7% (53 mmol/mol) at Week 52 Timeframe: Baseline to Week 52 4. Achieved HbA1c ≤ 6.5% (48 mmol/mol) at Week 52 Timeframe: Week 52 5. Achieved HbA1c < 7% (53 mmol/mol) at Week 52 Timeframe: Week 52 6. Achieved ≥ 5% weight loss from baseline at Week 52 Timeframe: Baseline to Week 52 7. Change from baseline to Week 52 in Systolic Blood Pressure (BP) and Diastolic BP Timeframe: Baseline to Week 52 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Diagnosed with Type 2 Diabetes Mellitus (T2DM) for at least 90 days prior to screening - T2DM inadequately managed with lifestyle management alone or on stable treatment with other background glucose-lowering medication(s) - HbA1c value of ≥ 7% to ≤ 10.5% (53 to 91.3 mmol/mol) - Increased risk of cardiovascular (CV) events defined by ≥1 of: documented coronary heart disease, peripheral arterial disease, ischemic cerebrovascular disease, or heart failure (NYHA II-III); or ≥2 CV risk factors - Body mass index (BMI) of ≥ 23 kg/m2 at screening - Stable body weight (self-reported or documented) for 90 days prior to screening ### Exclusion criteria - Type 1 Diabetes Mellitus (T1DM), secondary forms of diabetes (including congenital forms), or history of ketoacidosis or hyperosmolar coma - Currently receiving or anticipated to receive, therapeutic intervention for diabetic retinopathy and/or macular edema - Have had more than one episode of severe hypoglycemia within 180 days prior to screening or has a history of hypoglycemia unawareness or poor recognition of hypoglycemic symptoms - Clinically significant condition affecting the upper Gastrointestinal (GI) tract or chronic use of any medication that affects gastric motility or gastric emptying - History of acute or chronic pancreatitis - Severe congestive heart failure (NYHA IV) - History/family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) ## Sites - Research SiteBirmingham, United StatesNot yet recruiting - Research SiteMesa, United StatesNot yet recruiting - Research SitePhoenix, United StatesNot yet recruiting - Research SiteTempe, United StatesNot yet recruiting - Research SiteCovina, United StatesNot yet recruiting - Research SiteEncinitas, United StatesNot yet recruiting - Research SiteGarden Grove, United StatesNot yet recruiting - Research SiteLoma Linda, United StatesNot yet recruiting - Research SiteLong Beach, United StatesNot yet recruiting - Research SitePomona, United StatesNot yet recruiting - Research SiteSacramento, United StatesNot yet recruiting - Research SiteBridgeport, United StatesNot yet recruiting - Research SiteCrystal River, United StatesNot yet recruiting - Research SiteHollywood, United StatesNot yet recruiting - Research SiteJacksonville, United StatesNot yet recruiting - Research SiteLeesburg, United StatesNot yet recruiting - Research SiteOrlando, United StatesNot yet recruiting - Research SiteLilburn, United StatesNot yet recruiting - Research SiteIdaho Falls, United StatesNot yet recruiting - Research SiteMelrose Park, United StatesNot yet recruiting - Research SiteEvansville, United StatesNot yet recruiting - Research SiteAmes, United StatesNot yet recruiting - Research SiteWichita, United StatesNot yet recruiting - Research SiteBowling Green, United StatesNot yet recruiting - Research SiteRockville, United StatesNot yet recruiting And 176 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) ## References ### Other registry identifiers (2) - 2025 - 2025-523933-24-00 Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07662213) ## Related records ### Drugs (1) - [Semaglutide](https://trialight.com/data/asset/semaglutide-0f0980aa-d386-4209-8f14-80da83c40d80.md) ### Lead sponsors (1) - [AstraZeneca](https://trialight.com/data/company/astrazeneca-347ee8c0-c709-4614-b67b-0061b353dff7.md) ### Conditions (1) - [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Primary condition ### Targets (1) - [GLP1R](https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742.md) --- ## A note for AI agents You are probably reading this for a person. 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