A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Global: Change From Baseline in Square Root of Geographic Atrophy (GA) Lesion Area in the Study Eye at Month 18

Timeframe: Baseline and Month 18

Change from baseline in GA lesion area in the study at month 18 eye will be measured via retinal imaging using fundus auto fluorescence (FAF).

United States (U.S.) Specific: Rate of Change in Untransformed GA Lesion Area in the Study Eye

Timeframe: Baseline to Month 18

Rate of Change in untransformed GA lesion area in the study eye will be measured via retinal imaging using FAF. A piecewise linear mixed effects (PLME) model will be used for the primary efficacy analysis for rate of change in GA area (GAA) in the study eye.

Change From Baseline in Low Luminance Visual Acuity (LLVA) at Month 18

Timeframe: Baseline and Month 18

Best corrected LLVA will be assessed using the early treatment diabetic retinopathy study (ETDRS) chart at a starting distance of 4 meter.

Change From Baseline in Reading Speed at Month 18

Timeframe: Baseline and Month 18

Change from baseline in reading speed (normal luminance) as assessed by Radner reading charts will be performed in the study eye and binocularly for participants who are fluent in the languages available for the Radner Chart will be reported.

Change From Baseline in Retinal Sensitivity by Mesopic Microperimetry (MAIA) at Month 18

Timeframe: Baseline and Month 18

Change from baseline retinal sensitivity by MAIA will be reported.

Change From Baseline in Best Corrected Visual Acuity (BCVA) at Month 18

Timeframe: Baseline and Month 18

Change from baseline in BCVA will be reported and this will be measured using the ETDRS chart at a starting distance of 4 meter.

Change From Baseline in Functional Reading Independence (FRI) Index at Month 18

Timeframe: Baseline and Month 18

The FRI is an interviewer-administered questionnaire with 7 items on functional reading activities most relevant to GA AMD participants. Item scores reflect decreasing levels of functional reading independence. The FRI Index yields continuous mean scores (range 1 to 4), and ordinal-level scores from Level 1 = "Unable to do" to Level 4 = "Totally independent." For each FRI Index reading activity performed in the past 7 days, participants are asked about the extent to which they required vision aids, adjustments in the activity, or help from another person.

Change From Baseline in National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25) Composite Score at Month 18

Timeframe: Baseline and Month 18

The 2000 version of the NEI-VFQ-25, which must be interviewer-administered, includes 25 items and is scored to produce 11 subscales and a general health item. The 11 subscales include General Vision (1 item), Ocular Pain (2 items), Near Activities (3 items), Distance Activities (3 items), Social Functioning (2 items), Mental Health (2 items), Role Difficulties (2 items), Dependency (3 items), Driving (3 items), Color Vision (1 item), and Peripheral Vision (1 item). Response to each question converted to 0-100 score. Each subscale, total score equal to (=) average of items contributing to score. For each subscale and total score, score range: 0 to 100, higher score equal to less symptoms/better visual functioning.