> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-to-compare-tablets-and-capsules-of-orforglipron-3b00ad70-0c31-48a7-a71f-57c78dd8a28b > Record changed: 2026-10-13 # A Study to Compare Tablets and Capsules of Orforglipron (LY3502970) in Healthy Participants Who Are Obese or Overweight NCT06440980 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) Phase Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) Participants 533 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) Start date 2024-06-24 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) Number of sites 7 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) ## Title and summary **Summary** The main purpose of this study is to see how much of orforglipron (study drug) gets into the bloodstream and how long it takes the body to get rid of it when given as capsules compared to tablets in healthy overweight and obese participants. The safety and tolerability (side effects) of orforglipron when given as capsules and tablets will also be evaluated. The study will be conducted in two parts, with part A and B lasting up to approximately 25 and 22 weeks each respectively, including the screening period. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Short title** A Study to Compare Tablets and Capsules of Orforglipron (LY3502970) in Healthy Participants Who Are Obese or Overweight Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Official title** A Multiple-Dose Study to Investigate the Bioequivalence of Orforglipron (LY3502970) Capsules and Orforglipron Tablets in Participants With Obesity or Overweight Who Are Otherwise Healthy. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) ## Status and phase **Control arm** Open label Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Registry reports results** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Phase** Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) ## Dates **Completion date** 2025-06-02 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **First posted** 2024-06-04 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Registry last updated** 2026-07-17 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Primary completion date** 2025-06-02 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Start date** 2024-06-24 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) ## Size and sites **Actual participants** 533 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Participants** 533 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Protocol amendments** 5 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Number of sites** 7 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) ## Identifiers **Registry ID** NCT06440980 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **ClinicalTrials.gov ID** NCT06440980 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Basic science **Masking** No masking Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) ## Outcomes ### Primary outcomes 1. Part B: Pharmacokinetics (PK): Steady-state Area Under the Concentration Time Curve From Time Zero to the End of the Dosing Interval, Tau (AUC\[0-tau\]) of LY3502970 on Day 7 Timeframe: Pre-dose, 0.5, 1, 2, 4, 6, 8, 12, 16 and 24 hours post-dose on Day 7 for each dosing treatment period (1 period=7 days) PK: Area under the concentration versus time curve from time 0 to the end of the once daily dosing interval at steady state AUC\\\[0-tau\\\] on Day 7. 2. Part B: PK: Steady-state Maximum Observed Concentration (Cmax) of LY3502970 on Day 7 Timeframe: Pre-dose, 0.5, 1, 2, 4, 6, 8, 12, 16 and 24 hours post-dose on Day 7 for each dosing treatment period (1 period=7 days) PK: Maximum concentration of LY3502970 during a once daily dosing interval at steady state on Day 7. Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Maximum age** 65 Years **Healthy volunteers** Yes ### Inclusion criteria - Participants who are overtly healthy as determined by medical history and physical examination. - Have a stable body weight for one month prior to screening (less than or equal to 5 percent body weight gain or loss) and Body Mass Index (BMI) in range of 27 to 40 kilogram per meter square (kg/m²). - Participants must be reliable and willing to make themselves available for the duration of the study and are willing to follow study procedures. - Have venous access sufficient to allow for blood sampling. ### Exclusion criteria - Have hemoglobin A1c (HbA1c) level of 6.5 percent (%) or greater. - Have a history of current cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematological, or neurological disorders or other significant active, uncontrolled medical conditions. - Have significant history of or currently have major depressive disorder or psychiatric disorder within the last 2 years. - Obesity induced by other endocrine disorders, such as Cushing's syndrome or Prader-Willi syndrome. - Have known clinically significant gastric emptying abnormality. - Have undergone bariatric surgery (for example: Lap-Band, Gastric Bypass) - Have a known self or family history (first-degree relative) of multiple endocrine neoplasia type 2A or type 2B, thyroid C-cell hyperplasia, or any form of thyroid cancer. - Have an abnormal 12-lead electrocardiogram (ECG) at screening. - Have history of pancreatitis. - Judged by the study investigator to be at serious suicidal risk and have answered "Yes" to either question 4 or 5 on the Columbia-Suicide Severity Rating Scale \[C-SSRS\]). - Have difficulty swallowing capsules or tablets. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) ## Sites - Anaheim Clinical Trials, LLCAnaheim, United States - Collaborative Neuroscience Research, LLCLos Alamitos, United States - Fortrea Clinical Research UnitDaytona Beach, United States - Altasciences Company Inc.Overland Park, United States - QPSSpringfield, United States - Fortrea Clinical Research UnitDallas, United States - Fortrea Clinical Research UnitMadison, United States Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) ## References - PubMed 41994902 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/41994902/) Related publication - Related resource (trials.lilly.com) Source: [trials.lilly.com](https://trials.lilly.com/en-US/trial/495475) ### Other registry identifiers - J2A-MC-GZPI Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06440980) ## Related records ### Drugs (1) - [Orforglipron](https://trialight.com/data/asset/orforglipron-1138c12b-f1c7-45bb-b9ec-2b693f019a62.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (1) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) --- ## A note for AI agents You are probably reading this for a person. 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