> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-zt002-injection-with-subjects-with-overweight-or-e4bbd6e7-a637-4803-8e30-5820e216f9f3 > Record changed: 2026-10-13 # A Study of ZT002 Injection With Subjects With Overweight or Obesity NCT07020884 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) Phase Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) Participants 303 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) Lead sponsor Beijing QL Biopharmaceutical Co.,Ltd Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) Start date 2024-08-14 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) Number of sites 16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) ## Title and summary **Summary** This study will evaluate the percentage change from baseline in weight after 24 weeks of treatment with ZT002 Injection in subjects with overweight/obesity. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Short title** A Study of ZT002 Injection With Subjects With Overweight or Obesity Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Official title** A Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetic Characteristics of ZT002 Injection in Subjects With Overweight or Obesity Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Phase** Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) ## Dates **Completion date** 2025-05-29 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **First posted** 2025-06-13 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Registry last updated** 2025-12-10 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Primary completion date** 2025-05-07 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Start date** 2024-08-14 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) ## Size and sites **Actual participants** 303 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Participants** 303 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Number of sites** 16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Lead sponsor** Beijing QL Biopharmaceutical Co.,Ltd Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) ## Identifiers **Registry ID** NCT07020884 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **ClinicalTrials.gov ID** NCT07020884 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) ## Outcomes ### Primary outcomes 1. The percentage change from baseline in weight after 24 weeks of treatment. Timeframe: baseline, 24 weeks ### Secondary outcomes 1. The proportion of subjects with weight loss of ≥ 5%, ≥ 10%, and ≥ 15% from baseline after 24 weeks of treatment; Timeframe: 24 weeks Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Maximum age** 75 Years **Healthy volunteers** No ### Inclusion criteria - Age ≥ 18 years and ≤ 75 years. - BMI ≥28 kg/m², or 24 kg/m2 ≤ BMI < 28 kg/m2 with at least one comorbidity (pre-diabetes, hypertension, hyperlipidemia, fatty liver, obstructive sleep apnoea syndrome due to overweight, weight-bearing joint pain, etc.) - Weight change is not more than 5% with diet and exercise control alone within 3 months prior to screening. ### Exclusion criteria - Previous diagnosis of diabetes; or HbA1c ≥ 6\. 5% or fasting blood glucose ≥ 7.0 mmol/L at screening. - Have used medicines or treatments that affect weight within 3 months prior to screening. - History of acute or chronic pancreatitis. - Personal or family (parents, children, and siblings) history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia type II (MEN2). - History of definite mental disease within 2 years prior to screening or prior suicidal tendency or suicidal behavir; or PHQ-9 scale score is ≥ 15 at screening; or C-SSRS questionnaire is either class 4 or 5 at screening. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) ## Sites - Handan First HospitalHandan, China - Hebei Petro China Cental HospitalLangfang, China - First Hospital of QinhuangdaoQinhuangdao, China - The Fourth Affiliated Hospital Harbin Medical UniversityHarbin, China - The First Affiliated Hospital of Henan University of Science & TechnologyLuoyang, China - Luoyang Third People's HospitalLuoyang, China - The First Affiliated of Nanyang Medical CollegeNanyang, China - Nanjing Jiangning HospitalNanjing, China - Affiliated Hospital of Jiangsu UniversityZhenjiang, China - Tonghua Central HospitalTonghua, China - Genertec Liaoyou Gem Flower HospitalPanjin, China - Central Hospital Affiliated to Shandong First Medical UniversityJinan, China - Zibo Municipal HospitalZibo, China - Xi'an Daxing HospitalXi’an, China - Peking University First HospitalBeijing, China - Peking University People's HospitalBeijing, China Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07020884) ## Related records ### Drugs (1) - [Inpegsomatropin](https://trialight.com/data/asset/inpegsomatropin-c32ce698-951f-4d34-8540-b95205257692.md) ### Lead sponsors (1) - [Beijing QL Biopharmaceutical Co.,Ltd](https://trialight.com/data/company/beijing-ql-biopharmaceutical-co-ltd-7794eae0-b07c-433b-aa84-cba620b8b083.md) ### Conditions (1) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) --- ## A note for AI agents You are probably reading this for a person. 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