> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-tirzepatide-ly3298176-plus-mibavademab-compared-c3557fe0-b823-4551-acf4-9132fd6d2ef2 > Record changed: 2026-10-13 # A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity NCT06373146 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) Phase Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) Participants 392 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) Start date 2024-04-24 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) Number of sites 17 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) ## Title and summary **Summary** The main purpose of this study is to determine if combining tirzepatide with mibavademab will result in more weight loss in adult participants than tirzepatide alone. The study will last about 74 weeks and may include up to 19 visits. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Short title** A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Official title** A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Study of Once-Weekly Tirzepatide Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) ## Status and phase **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Phase** Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) ## Dates **Completion date** 2026-04-02 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **First posted** 2024-04-18 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Registry last updated** 2026-05-06 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Primary completion date** 2025-12-15 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Start date** 2024-04-24 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) ## Size and sites **Actual participants** 392 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Participants** 392 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Protocol amendments** 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Number of sites** 17 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) ## Identifiers **Registry ID** NCT06373146 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **ClinicalTrials.gov ID** NCT06373146 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) ## Outcomes ### Primary outcomes 1. Mean Percent Change from Baseline in Body Weight Timeframe: Baseline, Week 48 ### Secondary outcomes 1. Mean Change from Baseline for Percent Change and Absolute Change in Body Weight (kg) Timeframe: Baseline, Week 24 2. Mean Absolute Change from Baseline for Body Weight (kg) Timeframe: Baseline, Week 48 3. Percentage of Participants Who Achieve ≥5% Body Weight Reduction Timeframe: Baseline to Week 48 4. Percentage of Participants Who Achieve ≥10% Body Weight Reduction Timeframe: Baseline to Week 48 5. Percentage of Participants Who Achieve ≥15% Body Weight Reduction Timeframe: Baseline to Week 48 6. Percentage of Participants Who Achieve ≥20 Body Weight Reduction Timeframe: Baseline to Week 48 7. Mean Percent Change from Randomization 2 for Body Weight Timeframe: Week 24, Week 48 8. Mean Change from Randomization 2 for Body Weight (kg) Timeframe: Week 24, Week 48 9. Mean Absolute Change from Randomization 2 for Body Weight (kg) Timeframe: Week 24, Week 48 10. Change from Baseline to Week 24 in CoEQ Scores Timeframe: Baseline, Week 24 11. Change from Baseline to Week 48 in CoEQ Scores Timeframe: Baseline, Week 48 12. Change from Baseline in FCQ-T-r Scores Timeframe: Baseline, Week 24 13. Change from Baseline in FCQ-T-r Scores Timeframe: Baseline, Week 48 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Have a body mass index (BMI) of ≥30 kilogram/square meter (kg/m²) and ≤40 kg/m² - Willing to learn how to self-inject study intervention (visually impaired persons who are not able to perform the injections must have the assistance of a sighted individual trained to inject the study intervention; persons with physical limitations who are not able to perform the injections must have the assistance of an individual trained to inject the study intervention) - Male or female contraceptive use by participant should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. ### Exclusion criteria - Have a history of diabetes mellitus, including Type 1 Diabetes Mellitus (T1DM) or Type 2 Diabetes Mellitus (T2DM), history of ketoacidosis, or hyperosmolar state/coma - Have a self-reported change (increase or decrease) in body weight >5 kilogram (kg) within 3 months prior to screening - Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia (MEN) syndrome type 2 - Have acute or chronic hepatitis - Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) ## Sites - Velocity Clinical Research, GardenaGardena, United States - Irvine Clinical ResearchIrvine, United States - Velocity Clinical Research, Los AngelesLos Angeles, United States - Velocity Clinical Research, North HollywoodNorth Hollywood, United States - Velocity Clinical Research, Santa AnaSanta Ana, United States - Velocity Clinical Research, Panorama CityVan Nuys, United States - Diablo Clinical Research, Inc.Walnut Creek, United States - Solaris Clinical ResearchMeridian, United States - Tandem Clinical ResearchMarrero, United States - Velocity Clinical Research - New OrleansNew Orleans, United States - Hassman Research Institute Marlton SiteMarlton, United States - Lillestol ResearchFargo, United States - CTI Clinical Research CenterCincinnati, United States - South Texas Clinical ResearchCorpus Christi, United States - Velocity Clinical Research, DallasDallas, United States - Juno ResearchHouston, United States - Northwest Clinical Research CenterBellevue, United States Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) ## References - Related resource (trials.lilly.com) Source: [trials.lilly.com](https://trials.lilly.com/en-US/trial/477977) ### Other registry identifiers - I8F-MC-GPIV Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06373146) ## Related records ### Drugs (2) - [Mibavademab](https://trialight.com/data/asset/mibavademab-2c530b5c-9ec4-4d42-aff7-3454ecd7d355.md) - [Tirzepatide](https://trialight.com/data/asset/tirzepatide-eed85871-eb9c-4712-9102-badfdd99a720.md) ### Collaborators (1) - [Regeneron Pharmaceuticals](https://trialight.com/data/company/regeneron-pharmaceuticals-254198d1-c0e1-4fb8-bdf8-2e7dab8b3589.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (1) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Primary condition ### Targets (3) - [GIPR](https://trialight.com/data/target/gipr-5b65dd73-9875-5aca-be7a-5469a7290f0c.md) - [GLP1R](https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742.md) - [LEPR](https://trialight.com/data/target/lepr-e64d0b1f-f2f9-59a4-9ae4-f6871c5f5e34.md) --- ## A note for AI agents You are probably reading this for a person. 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