> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-tirzepatide-ly3298176-compared-with-placebo-in-65c87e2c-3a6d-4262-8390-80948c27f1f7 > Record changed: 2026-11-04 # A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight NCT06914895 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) Recruitment status Active, not recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) Participants 905 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) Start date 2025-04-25 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) Number of sites 146 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) ## Title and summary **Summary** The main purpose of this study is to find out how well and how safely tirzepatide works in adults who have type 1 diabetes and obesity or overweight. Participation in the study will last about 49 weeks. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Acronym** SURPASS-T1D-1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Short title** A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Official title** A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Evaluating the Efficacy and Safety of Tirzepatide Once Weekly Compared to Placebo in Adult Participants With Type 1 Diabetes and Obesity or Overweight Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Recruitment status** Active, not recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) ## Dates **Completion date** 2026-12-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **First posted** 2025-04-06 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Registry last updated** 2026-05-12 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Primary completion date** 2026-11-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Start date** 2025-04-25 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) ## Size and sites **Participants** 905 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Planned participants** 905 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Number of sites** 146 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) ## Identifiers **Registry ID** NCT06914895 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **ClinicalTrials.gov ID** NCT06914895 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) ## Outcomes ### Primary outcomes 1. Change from Baseline in Hemoglobin A1c (HbA1c) Timeframe: Baseline, Week 40 ### Secondary outcomes 1. Percentage of Time Continuous Glucose Monitor (CGM) Glucose Values are Between 70 and 180 milligrams per deciliter (mg/dL) (3.9 and 10.0 millimoles per liter (mmol/L) Inclusive, Per Day Timeframe: Within 30 days prior to Week 40 2. Change from Baseline in Body Weight Timeframe: Baseline, Week 40 3. Percent Change from Baseline in Body Weight Timeframe: Baseline, Week 40 4. Percentage of Participants with ≥5% Body Weight Reduction Timeframe: Baseline, Week 40 5. Percentage of Participants with ≥10% Body Weight Reduction Timeframe: Baseline, Week 40 6. Percentage of Participants with ≥15% Body Weight Reduction Timeframe: Baseline, Week 40 7. Change from Baseline in Waist Circumference Timeframe: Baseline, Week 40 8. Change from Baseline in Systolic Blood Pressure (SBP) Timeframe: Baseline, Week 40 9. Percent Change from Baseline in Fasting Triglycerides Timeframe: Baseline, Week 40 10. Percent Change from Baseline in Fasting Non-High-Density Lipoprotein (non-HDL) Cholesterol Timeframe: Baseline, Week 40 11. Percent Change from Baseline in Total Daily Insulin Dose Timeframe: Baseline, Week 40 12. Percent Change from Baseline in High-Sensitivity C-Reactive Protein (hsCRP) Timeframe: Baseline, Week 40 13. Change from Baseline in EQ-5D-5L Timeframe: Baseline, Week 40 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Have type 1 diabetes and on insulin treatment for at least one year prior to screening - Have an HbA1c value of 7.0% to 10.5% inclusive, at screening - Have a body mass index (BMI) of ≥25 kilograms per square meter (kg/m2) at screening - Are of stable weight for at least 90 days prior to screening and agree to not start an intensive diet or exercise program during the study ### Exclusion criteria - Have experienced two or more events requiring hospitalization due to poor glucose control (hyperglycemia or (diabetic ketoacidosis (DKA)) during the period of 180 days prior to screening and until randomization. - Have experienced one or more events of severe hypoglycemia during the period of 90 days prior to screening and until randomization. - Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema - Have had chronic or acute pancreatitis - Have used any weight loss drugs or alternative remedies, including herbal or nutritional supplements, within 90 days prior to screening Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) ## Sites - Sansum Diabetes Research InstituteSanta Barbara, United States - Care Access - Santa ClaritaSanta Clarita, United States - University of Colorado Anschutz Medical CampusAurora, United States - Atlanta Diabetes AssociatesAtlanta, United States - Orita Clinical ResearchDecatur, United States - North Georgia Clinical ResearchWoodstock, United States - East-West Medical Research InstituteHonolulu, United States - Rocky Mountain Clinical ResearchIdaho Falls, United States - Southern Illinois University School of MedicineSpringfield, United States - Indiana University Health University HospitalIndianapolis, United States - Iowa Diabetes and Endocrinology Research CenterWest Des Moines, United States - Endocrine and Metabolic ConsultantsRockville, United States - HealthPartners Institute dba International Diabetes CenterMinneapolis, United States - SKY Integrative Medical Center/SKYCRNGRidgeland, United States - Boeson Research MSOMissoula, United States - Palm Research Center TenayaLas Vegas, United States - Palm Research Center SunsetLas Vegas, United States - Albany Medical College, Division of Community EndocrinologyAlbany, United States - Research Foundation of SUNY - University of BuffaloBuffalo, United States - NYC ResearchNew York, United States - SUNY Upstate Medical UniversitySyracuse, United States - Lucas Research, Inc.Morehead City, United States - Care Access - LimaLima, United States - Alliance for Multispecialty Research, LLCNorman, United States - Suburban Research AssociatesWest Chester, United States And 121 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) ## References - Related resource (trials.lilly.com) Source: [trials.lilly.com](https://trials.lilly.com/en-US/trial/589916) ### Other registry identifiers (2) - 2024-519684-17-00 - I8F-MC-GPJA Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06914895) ## Related records ### Drugs (1) - [Tirzepatide](https://trialight.com/data/asset/tirzepatide-eed85871-eb9c-4712-9102-badfdd99a720.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (2) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) - [Type 1 diabetes mellitus](https://trialight.com/data/condition/type-1-diabetes-mellitus-c22c640e-5db9-525c-8e4b-8da31250a7a3.md) Primary condition ### Targets (2) - [GIPR](https://trialight.com/data/target/gipr-5b65dd73-9875-5aca-be7a-5469a7290f0c.md) - [GLP1R](https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742.md) --- ## A note for AI agents You are probably reading this for a person. 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