> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-shr-a2102-in-combination-with-other-anti-tumor-61629f16-71e8-4735-9844-f28ecacc8b00 > Record changed: 2026-10-13 # A Study of SHR-A2102 in Combination With Other Anti-tumor Therapies for Resectable Non-small Cell Lung Cancer NCT07229729 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) Phase Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) Recruitment status Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) Participants 300 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) Lead sponsor Shanghai Hengrui Pharmaceutical Co., Ltd. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) Start date 2025-11-24 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) Number of sites 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) ## Title and summary **Summary** The study is a Phase II study to explore the efficacy and safety of SHR-A2102 in combination with other anti-tumor therapies as perioperative treatment in patients with resectable non-small cell lung cancer. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Short title** A Study of SHR-A2102 in Combination With Other Anti-tumor Therapies for Resectable Non-small Cell Lung Cancer Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Official title** A Randomized, Open-label, Multicenter Phase II Clinical Study of SHR-A2102 in Combination With Other Anti-tumor Therapies for Perioperative Treatment of Resectable Non-small Cell Lung Cancer Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) ## Status and phase **Control arm** Active comparator Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Recruitment status** Recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Phase** Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) ## Dates **Completion date** 2029-10-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **First posted** 2025-11-17 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Registry last updated** 2025-12-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Primary completion date** 2026-10-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Start date** 2025-11-24 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) ## Size and sites **Participants** 300 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Planned participants** 300 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Number of sites** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) ## Sponsor and oversight **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Lead sponsor** Shanghai Hengrui Pharmaceutical Co., Ltd. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) ## Identifiers **Registry ID** NCT07229729 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **ClinicalTrials.gov ID** NCT07229729 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** No masking Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) ## Outcomes ### Primary outcomes 1. Pathology complete response (pCR) Timeframe: Up to approximately 20 weeks. 2. 18-month event free rate Timeframe: Up to approximately 18 months. 3. 2-years disease free rate Timeframe: Up to approximately 2 years. ### Secondary outcomes 1. Event free survival (EFS) Timeframe: Up to approximately 5 years. 2. Overall survival (OS) Timeframe: Up to approximately 5 years. 3. Objective response rate (ORR) Timeframe: Up to approximately 20 weeks. 4. Disease-Free Survival (DFS) Timeframe: Up to approximately 5 years. 5. Adverse events (AEs) Timeframe: Up to approximately 5 years. Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Maximum age** 70 Years **Healthy volunteers** No ### Inclusion criteria 1. Voluntarily participate in this clinical study, understand the research procedures and be able to sign the informed consent form in writing; 2. Participants must be aged between 18 and 70 years old (inclusive) when signing the informed consent form, and both men and women are eligible; 3. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1; 4. Adequate organ function; 5. Women of childbearing age must undergo serum pregnancy tests, and the results must be negative. Female subjects of childbearing age and male subjects who are partners of women of childbearing age must agree to use highly effective contraceptive methods. ### Exclusion criteria 1. With active, known or suspected autoimmune disease of autoimmune disease; 2. Malignancies other than NSCLC within 5 years prior to randomization; 3. Has or suspected has a history of pneumonitis / interstitial lung disease or any serve lung diseases which will influence the examination of lung function; 4. Significant history of cardiovascular and cerebrovascular disease; Significant haemorrhagic disease; 5. Has an arteriovenous thrombotic events; 6. Has a known history of human immunodeficiency virus (HIV) infection; 7. Has a known active Hepatitis B or Hepatitis C; 8. Allergic to the intervention regimens. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) ## Sites - Guangdong Provincial People's HospitalGuangzhou, ChinaRecruiting Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07229729) ## Related records ### Drugs (4) - [Adebrelimab](https://trialight.com/data/asset/adebrelimab-047820dd-1777-483d-90ab-dd5fc86f78f6.md) - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) - [Osimertinib mesylate](https://trialight.com/data/asset/osimertinib-mesylate-1174023a-e2bd-4773-ad07-2566cbd51026.md) - [Paclitaxel](https://trialight.com/data/asset/paclitaxel-889db92c-df97-46a6-bf1c-74974a87fa75.md) ### Lead sponsors (1) - [Shanghai Hengrui Pharmaceutical Co., Ltd.](https://trialight.com/data/company/shanghai-hengrui-pharmaceutical-co-ltd-99e79134-0170-4beb-ba13-f33c49843c3e.md) ### Conditions (1) - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Primary condition ### Targets (17) - [CD274](https://trialight.com/data/target/cd274-67467e37-9325-584a-be55-e3ef69f22b4c.md) - [EGFR](https://trialight.com/data/target/egfr-5c134fbe-bf90-5792-81e3-542be53c2be7.md) - [TUBA1A](https://trialight.com/data/target/tuba1a-f463ed42-1a60-5499-a9d4-1b9bf58dc1a0.md) - [TUBA1B](https://trialight.com/data/target/tuba1b-9d713a5c-e5d0-50cb-852e-c74562888bab.md) - [TUBA1C](https://trialight.com/data/target/tuba1c-308bfde0-cfab-509b-8c74-457db8c8b365.md) - [TUBA3C](https://trialight.com/data/target/tuba3c-4abfb5fd-1449-5948-844d-76d4c28b3ca5.md) - [TUBA3E](https://trialight.com/data/target/tuba3e-3cb5d4e3-43d1-5066-b94a-f3fe2b9f7812.md) - [TUBA4A](https://trialight.com/data/target/tuba4a-5a3e4e1b-bf84-5903-89e9-0dda280376ab.md) - [TUBB](https://trialight.com/data/target/tubb-ec240191-c297-5eba-9021-60488341c8f3.md) - [TUBB1](https://trialight.com/data/target/tubb1-aea59905-0cc2-5a62-be89-e62ea633ec75.md) - [TUBB2A](https://trialight.com/data/target/tubb2a-d05cd610-e1d8-5bbe-a299-897fd869fa9f.md) - [TUBB2B](https://trialight.com/data/target/tubb2b-23c4b067-2275-52fa-8ab9-3c15fac539bb.md) - [TUBB3](https://trialight.com/data/target/tubb3-2961b200-1591-50aa-93ae-4a54a10915e9.md) - [TUBB4A](https://trialight.com/data/target/tubb4a-ad5f7184-fd22-58b7-a66c-95289ce2e093.md) - [TUBB4B](https://trialight.com/data/target/tubb4b-1b93a23c-a19e-5d34-93be-30d58939e047.md) - [TUBB6](https://trialight.com/data/target/tubb6-9f2941d7-b631-5e8b-b148-6bde2a6caf22.md) - [TUBB8](https://trialight.com/data/target/tubb8-f8700f93-4301-5eda-9407-55f76aa16a06.md) --- ## A note for AI agents You are probably reading this for a person. 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