> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-retatrutide-ly3437943-in-participants-with-9be48e7b-d96b-4085-9f61-f5ee225547ad > Record changed: 2026-11-04 # A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease NCT05882045 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) Participants 1,946 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) Start date 2023-05-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) Number of sites 169 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) ## Title and summary **Summary** The main purpose of this study is to evaluate the efficacy and safety of retatrutide once weekly in participants with obesity and established cardiovascular disease (CVD). The study will last about 113 weeks. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Acronym** TRIUMPH-3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Short title** A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Official title** A Randomized, Double-Blind, Phase 3 Study to Investigate the Efficacy and Safety of LY3437943 Once Weekly Compared to Placebo in Participants With Severe Obesity and Established Cardiovascular Disease Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) ## Dates **Completion date** 2026-05-14 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **First posted** 2023-05-31 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Registry last updated** 2026-07-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Primary completion date** 2026-04-16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Start date** 2023-05-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) ## Size and sites **Actual participants** 1,946 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Participants** 1,946 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Number of sites** 169 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) ## Identifiers **Registry ID** NCT05882045 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **ClinicalTrials.gov ID** NCT05882045 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) ## Outcomes ### Primary outcomes 1. Percent Change from Baseline in Body Weight Timeframe: Baseline, Week 80 ### Secondary outcomes 1. Change from Baseline in Body Mass Index (BMI) Timeframe: Baseline, Week 80 2. Change from Baseline in Waist Circumference Timeframe: Baseline, Week 80 3. Percent Change from Baseline in Total Cholesterol Timeframe: Baseline, Week 80 4. Percent Change from Baseline in Triglycerides Timeframe: Baseline, Week 80 5. Change from Baseline in Systolic Blood Pressure (SBP) Timeframe: Baseline, Week 80 6. Change from Baseline in Diastolic Blood Pressure (DBP) Timeframe: Baseline, Week 80 7. Change from Baseline in Hemoglobin A1c (HbA1c) Timeframe: Baseline, Week 80 8. Percent Change from Baseline in Fasting Insulin Timeframe: Baseline, Week 80 9. Change from Baseline in Short Form version 2 (SF-36v2) Acute Form Physical Function Domain Score Timeframe: Baseline, Week 80 10. Pharmacokinetics (PK): Steady State Area Under the Concentration Time Cure (AUC) Timeframe: Baseline to Week 80 AUC is presented as a single average measure of AUC across the study duration. Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Have a body mass index (BMI) ≥35.0 kilogram/square meter (kg/m²). - Have established cardiovascular (CV) disease with at least 1 of the following: - prior myocardial infarction - prior ischemic or hemorrhagic stroke, or - symptomatic peripheral arterial disease - Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight. ### Exclusion criteria - Have had acute myocardial infarction, stroke, coronary revascularization, hospitalization for unstable angina, or hospitalization due to congestive heart failure within 90 days prior to screening. - Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening. - Have a prior or planned surgical treatment of obesity. - Have a change in body weight greater than 5 kg (11 pounds) within 90 days prior to screening. - Have Type 1 diabetes. - Have family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2) - Have had pancreatitis. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) ## Sites - Central Phoenix Medical ClinicPhoenix, United States - Valley Clinical Trials, Inc.Covina, United States - Neuro-Pain Medical CenterFresno, United States - Valley ResearchFresno, United States - Collaborative Neuroscience Research, LLCLos Alamitos, United States - Velocity Clinical Research, WestlakeLos Angeles, United States - Valley Clinical Trials, Inc.Northridge, United States - Velocity Clinical Research, Panorama CityVan Nuys, United States - Chase Medical Research, LLCWaterbury, United States - Indago Research & Health Center, IncHialeah, United States - Clinical Neuroscience Solutions, Inc. dba CNS HealthcareJacksonville, United States - Clinical Neuroscience Solutions, Inc.Orlando, United States - Charter Research - Winter ParkOrlando, United States - Progressive Medical ResearchPort Orange, United States - Pacific Diabetes & Endocrine CenterHonolulu, United States - Elite Clinical TrialsBlackfoot, United States - Humphreys Diabetes CenterBoise, United States - Northwestern UniversityChicago, United States - Great Lakes Clinical Trials - GurneeGurnee, United States - Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research CooperativeSpringfield, United States - Brengle Family MedicineIndianapolis, United States - Iowa Diabetes and Endocrinology Research CenterWest Des Moines, United States - Cotton O'Neil Diabetes & EndocrinologyTopeka, United States - MedVadis Research CorporationWaltham, United States - StudyMetrix ResearchCity of Saint Peters, United States And 144 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) ## References - Related resource (trials.lilly.com) Source: [trials.lilly.com](https://trials.lilly.com/en-US/trial/405675) ### Other registry identifiers (3) - 2023 - 2023-503659-88-00 - J1I-MC-GZBM Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882045) ## Related records ### Drugs (1) - [Retatrutide](https://trialight.com/data/asset/retatrutide-1c18d390-804a-469b-95a1-d654ddcca41e.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (2) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Primary condition ### Targets (3) - [GCGR](https://trialight.com/data/target/gcgr-418174f7-cf4a-56a4-9273-4cd98d0bc903.md) - [GIPR](https://trialight.com/data/target/gipr-5b65dd73-9875-5aca-be7a-5469a7290f0c.md) - [GLP1R](https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742.md) --- ## A note for AI agents You are probably reading this for a person. 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