> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/trial/a-study-of-orforglipron-in-adult-participants-with-obesity-44902e48-ce49-4c11-951b-c97e5cc850d4
> Record changed: 2026-10-13

# A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes

NCT05872620

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

Phase

Phase 3

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

Recruitment status

Completed

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

Participants

1,613

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

Lead sponsor

Eli Lilly and Company

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

Start date

2023-06-05

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

Number of sites

136

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

## Title and summary

**Summary**

This study will investigate the safety and efficacy of once daily oral treatment with orforglipron compared with placebo on body weight in adult participants with obesity or overweight and type 2 diabetes. The study will last about 77 weeks and may include up to 22 visits.

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Acronym**

ATTAIN-2

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Short title**

A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Official title**

A Phase 3, Randomized, Double-Blind Study to Investigate the Efficacy and Safety of Once-Daily Oral LY3502970 Compared With Placebo in Adult Participants With Obesity or Overweight and Type 2 Diabetes (ATTAIN-2)

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

## Status and phase

**Control arm**

Placebo

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Registry reports results**

No

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Listing at source**

Listed

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Recruitment status**

Completed

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Phase**

Phase 3

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Study type**

Interventional

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

## Dates

**Completion date**

2025-08-08

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**First posted**

2023-05-24

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Registry last updated**

2025-09-18

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Primary completion date**

2025-08-08

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Start date**

2023-06-05

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

## Size and sites

**Actual participants**

1,613

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Participants**

1,613

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Participant count basis**

Actual

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Protocol amendments**

1

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Number of sites**

136

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

## Sponsor and oversight

**Data monitoring committee**

No

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Registry sponsor category**

Industry

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Lead sponsor**

Eli Lilly and Company

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Source registry**

ClinicalTrials.gov

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

## Identifiers

**Registry ID**

NCT05872620

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**ClinicalTrials.gov ID**

NCT05872620

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

**Registry record**

Open registry record

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

## Study design

**Allocation**

Randomised

**Model**

Parallel groups

**Purpose**

Treatment

**Masking**

Double masking

**Masked roles**

Participants, Investigators

Sources for study design

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

## Outcomes

### Primary outcomes

1. Mean Percent Change from Baseline in Body Weight  
Timeframe: Baseline, Week 72

### Secondary outcomes

1. Mean Change from Baseline in Waist Circumference  
Timeframe: Baseline, Week 72
2. Mean Change from Baseline in Hemoglobin A1c (HbA1c) %  
Timeframe: Baseline, Week 72
3. Mean Change from Baseline in Fasting Glucose  
Timeframe: Baseline, Week 72
4. Mean Change from Baseline in Systolic Blood Pressure (SBP)  
Timeframe: Baseline, Week 72
5. Mean Change from Baseline in Fasting Triglycerides  
Timeframe: Baseline, Week 72
6. Mean Percent Change from Baseline in Fasting non-High-Density Lipoprotein (HDL) Cholesterol  
Timeframe: Baseline, Week 72
7. Mean Percent Change from Baseline in Fasting Insulin  
Timeframe: Baseline, Week 72
8. Mean Change from Baseline in Diastolic Blood Pressure (DBP)  
Timeframe: Baseline, Week 72
9. Mean Change from Baseline in Short Form 36 Version 2 Health Survey Acute Form (SF-36v2) Domain Scores  
Timeframe: Baseline, Week 72

Sources for outcomes

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

## Eligibility

**Sex**

All

**Age groups**

Adults, Older adults

**Minimum age**

18 Years

**Healthy volunteers**

No

### Inclusion criteria

- Have a body mass index (BMI) ≥27.0 kilogram/square meter (kg/m²).
- Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight.
- Have a diagnosis of Type 2 Diabetes (T2D), with HbA1c ≥7% (≥53 mmol/mol) to ≤10% (86 mmol/mol) and are on stable treatment for T2D for at least 90 days prior to screening, consisting of:

  - either diet/exercise alone or
  - up to 3 oral antihyperglycemic medications (excluding dipeptidyl peptidase IV inhibitors (DPP-4i) or glucagon-like peptide-1 (GLP-1) receptor agonists (RA).

### Exclusion criteria

- Have Type 1 Diabetes (T1D), history of ketoacidosis or hyperosmolar state/coma, or any other types of diabetes except T2D.
- Have a self-reported change in body weight >5 kg (11 pounds) within 90 days prior to screening.
- Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema (for example, laster photocoagulation or intravitreal injections of anti-vascular endothelial growth factor inhibitors).
- Have family (first-degree relative) or personal history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia 2 (MEN2) syndrome.
- Have had a history of chronic or acute pancreatitis.

Sources for eligibility

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

## Sites

- Cahaba Research - PelhamPelham, United States
- Novak Clinical Research - Tucson - North La Cholla BoulevardTucson, United States
- Yuma Clinical TrialsYuma, United States
- AMCR InstituteEscondido, United States
- Velocity Clinical Research, Huntington ParkHuntington Park, United States
- Velocity Clinical Research, WestlakeLos Angeles, United States
- Catalina Research Institute, LLCMontclair, United States
- University Clinical Investigators, Inc.Tustin, United States
- Encore Medical ResearchHollywood, United States
- East Coast Institute for Research, LLCJacksonville, United States
- South Florida Clinical Research InstituteMargate, United States
- Suncoast Clinical Research, Inc.New Port Richey, United States
- Balanced Life Health Care Solutions/SKYCRNGLawrenceville, United States
- Endocrine Research Solutions, Inc.Roswell, United States
- North Georgia Clinical ResearchWoodstock, United States
- Pacific Diabetes & Endocrine CenterHonolulu, United States
- Solaris Clinical ResearchMeridian, United States
- Iowa Diabetes and Endocrinology Research CenterWest Des Moines, United States
- MedStar Good Samaritan HospitalBaltimore, United States
- Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionTroy, United States
- StudyMetrix ResearchCity of Saint Peters, United States
- Las Vegas Medical ResearchLas Vegas, United States
- IMA Clinical ResearchAlbuquerque, United States
- Albany Medical College, Division of Community EndocrinologyAlbany, United States
- Albany Stratton VA Medical CenterAlbany, United States

And 111 more, listed on the interactive page.

Sources for sites

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

## References

- PubMed 42577069  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/42577069/)
Related publication
- PubMed 41275875  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/41275875/)
Related publication

- Related resource (trials.lilly.com)  
Source: [trials.lilly.com](https://trials.lilly.com/en-US/trial/404300)

### Other registry identifiers (2)

- U1111-1289-8799
- J2A-MC-GZGQ

Sources for references

Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05872620)

## Related records

### Drugs (1)

- [Orforglipron](https://trialight.com/data/asset/orforglipron-1138c12b-f1c7-45bb-b9ec-2b693f019a62.md)

### Lead sponsors (1)

- [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md)

### Conditions (2)

- [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Primary condition
- [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md)

---

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