> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-olomorasib-ly3537982-in-healthy-japanese-5adb93b0-1405-4633-bc22-e8b783ed958d > Record changed: 2026-10-13 # A Study of Olomorasib (LY3537982) in Healthy Japanese Participants NCT07124013 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) Phase Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) Participants 191 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) Start date 2025-09-16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) Number of sites 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) ## Title and summary **Summary** The purpose of this study is to compare and see how food affects the amount of olomorasib in the blood when olomorasib is taken in two different capsule forms. Participation in the study will last approximately 6 weeks. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Short title** A Study of Olomorasib (LY3537982) in Healthy Japanese Participants Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Official title** An Open-Label, Phase 1 Study to Investigate the Comparability of the Pharmacokinetics of Olomorasib (LY3537982) Between Two Capsule Formulations and to Evaluate the Food Effect in Healthy Japanese Participants Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) ## Status and phase **Control arm** Open label Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Phase** Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) ## Dates **Completion date** 2026-01-05 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **First posted** 2025-08-15 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Registry last updated** 2026-01-16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Primary completion date** 2026-01-05 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Start date** 2025-09-16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) ## Size and sites **Actual participants** 191 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Participants** 191 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Number of sites** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) ## Identifiers **Registry ID** NCT07124013 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **ClinicalTrials.gov ID** NCT07124013 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) ## Study design **Allocation** Randomised **Model** Crossover **Purpose** Basic science **Masking** No masking Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) ## Outcomes ### Primary outcomes 1. Pharmacokinetics (PK): Maximum Concentration (Cmax) of Olomorasib Timeframe: Day 1 (Predose) through Day 7 (72 Hours Postdose) 2. PK: Area under the Concentration versus Time Curve from Time Zero to Time t (AUC\[0-tlast\]) of Olomorasib Timeframe: Day 1 (Predose) through Day 7 (72 Hours Postdose) Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) ## Eligibility **Sex** Male **Age groups** Adults **Minimum age** 18 Years **Maximum age** 55 Years **Healthy volunteers** Yes ### Inclusion criteria - Japanese participants who are overtly healthy as determined by medical evaluation including medical history, 12 lead electrocardiogram (ECG), vital sign measurements, and clinical laboratory evaluations. - Have a body mass index within the range 18.5 to 30.0 kilograms per square meter (kg/m²), inclusive, at screening. - Participants assigned male at birth (AMAB) may participate in this study. ### Exclusion criteria - Have a history of malignancy within 5 years prior to screening except for basal cell or squamous epithelial carcinomas of the skin or in situ carcinoma of the cervix that have been resected with no evidence of metastatic disease for 3 years. - Have known allergies to olomorasib or any component of the formulation, or related compounds. - Use of any other investigational drug or device within 30 days or 5 half-lives (if known), whichever is longer, of the first dose of study drug. - Have previously completed or withdrawn from this study or any other study investigating olomorasib and have previously received olomorasib - Show evidence of hepatitis B or positive hepatitis B surface antigen. - Show evidence of hepatitis C or have a positive hepatitis C virus antibody test. - Show evidence of HIV infection or positive HIV antigen or HIV antibodies. - Show evidence of syphilis or have a positive syphilis test. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) ## Sites - Souseikai Fukuoka Mirai HospitalFukuoka, Japan Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) ## References ### Other registry identifiers - J3M-JE-JZQL Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07124013) ## Related records ### Drugs (1) - [Olomorasib](https://trialight.com/data/asset/olomorasib-96d5c218-8b5d-4ae5-b9d4-970dd492f808.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) --- ## A note for AI agents You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them. - Cite this page with its date. 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