> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-ly3841136-in-healthy-and-overweight-participants-0a0b3ce6-0feb-4491-9b2c-cb59e68a2c95 > Record changed: 2026-10-13 # A Study of LY3841136 in Healthy and Overweight Participants NCT05295940 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) Phase Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) Participants 148 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) Start date 2022-03-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) Number of sites 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) ## Title and summary **Summary** The main purpose of this study is to evaluate the safety and tolerability of LY3841136 in healthy and overweight participants. Blood tests will be performed to check how much LY3841136 gets into the bloodstream and how long it takes the body to eliminate it. This is a 2-part study and may last up to 14 and 28 weeks for each participant and may include 7 and 19 visits in parts A and B, respectively. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Short title** A Study of LY3841136 in Healthy and Overweight Participants Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Official title** A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY3841136 in Healthy and Overweight Participants Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Phase** Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) ## Dates **Completion date** 2024-01-25 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **First posted** 2022-03-25 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Registry last updated** 2024-04-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Primary completion date** 2024-01-25 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Start date** 2022-03-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) ## Size and sites **Actual participants** 148 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Participants** 148 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Number of sites** 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) ## Identifiers **Registry ID** NCT05295940 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **ClinicalTrials.gov ID** NCT05295940 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Basic science **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) ## Outcomes ### Primary outcomes 1. Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration Timeframe: Predose up to 14 weeks (Part A) & 28 weeks (Part B) A summary of TEAEs, SAEs and other non-serious adverse events (AEs), regardless of causality, will be reported in the Reported Adverse Events module ### Secondary outcomes 1. Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve (AUC) of LY3841136 Timeframe: Predose through week 14 (Part A) & week 28 (Part B) PK: AUC of LY3841136 2. PK: Maximum Observed Concentration (Cmax) of LY3841136 Timeframe: Predose through week 14 (Part A) & week 28 (Part B) PK: Cmax of LY3841136 3. Pharmacodynamics (PD): Change From Baseline in Body Weight Timeframe: Predose through week 28 PD: Change From Baseline in Body Weight Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Maximum age** 65 Years **Healthy volunteers** Yes ### Inclusion criteria - Male participants who agree to use highly effective/effective methods of contraception and female participants not of childbearing potential - Have had a stable weight for the last 3 months - Have a body mass index (BMI) in the range of 18.5 to 32 kilogram per square meter (kg/m²), both inclusive (in Part A) or a BMI in the range of 27 to 40 kg/m², both inclusive (in Part B) ### Exclusion criteria - Are women who are lactating - Have known allergies to related compounds of LY3841136 or any components of the formulation - Have a history of significant atopy (severe or multiple allergic manifestations), or clinically significant multiple or severe drug allergies, or severe posttreatment hypersensitivity reactions - Have been diagnosed with Type 1 or Type 2 diabetes mellitus - Have a history of chronic medical conditions involving the heart, liver, or kidneys Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) ## Sites - Fortrea Clinical Research UnitDaytona Beach, United States - Fortrea Clinical Research UnitDallas, United States - Fortrea Clinical Research UnitMadison, United States Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) ## References - PubMed 41109426 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/41109426/) Related publication ### Other registry identifiers - J3R-MC-YDAA Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05295940) ## Related records ### Drugs (1) - [Eloralintide](https://trialight.com/data/asset/eloralintide-ccf70d16-4bb8-42b3-b3e3-491d8fbd44a8.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (1) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Primary condition --- ## A note for AI agents You are probably reading this for a person. 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