> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-ly3532226-in-participants-with-obesity-6fc554c5-003d-4f7c-8581-f8a9b61bba6e > Record changed: 2026-11-04 # A Study of LY3532226 in Participants With Obesity NCT06557356 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) Phase Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) Participants 132 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) Start date 2024-08-16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) Number of sites 4 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) ## Title and summary **Summary** The main purpose of this study is to evaluate the safety and tolerability of the study drug known as LY3532226 in participants with obesity. Blood tests will be performed to check how much LY3532226 gets into the bloodstream and how long it takes the body to eliminate it following weekly or monthly administration. Part A of the study will last approximately 16 weeks, excluding screening period. Part B of the study will last approximately 20 weeks, excluding the screening period. Part C of the study will last approximately 8 weeks, excluding the screening period. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Short title** A Study of LY3532226 in Participants With Obesity Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Official title** A Dose-Escalation Phase 1, Investigator- and Participant-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Doses of LY3532226 in Participants With Obesity Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Phase** Phase 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) ## Dates **Completion date** 2025-12-12 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **First posted** 2024-08-16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Registry last updated** 2026-01-20 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Primary completion date** 2025-12-12 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Start date** 2024-08-16 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) ## Size and sites **Actual participants** 132 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Participants** 132 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Protocol amendments** 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Number of sites** 4 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) ## Identifiers **Registry ID** NCT06557356 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **ClinicalTrials.gov ID** NCT06557356 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Basic science **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) ## Outcomes ### Primary outcomes 1. Part A: Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration Timeframe: Baseline to Study Completion (Up to 16 Weeks) A summary of TEAEs and SAEs, regardless of causality, will be reported in the Reported Adverse Events module 2. Part B: Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration Timeframe: Baseline to Study Completion (Up to 20 Weeks) A summary of TEAEs and SAEs, regardless of causality, will be reported in the Reported Adverse Events module 3. Part C: Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration Timeframe: Baseline to Study Completion (Up to 8 Weeks)\] A summary of TEAEs and SAEs, regardless of causality, will be reported in the Reported Adverse Events module ### Secondary outcomes 1. Part A: Pharmacokinetics (PK): Maximum Concentration (Cmax) of LY3532226 Timeframe: Predose on Day 1 through Week 16 PK: Cmax of LY3532226 2. Part A: PK: Area Under the Concentration Versus Time Curve (AUC) of LY3532226 Timeframe: Predose on Day 1 through Week 16 PK: AUC of LY3532226 3. Part B: PK: Cmax of LY3532226 Timeframe: Predose on Day 1 through Week 20 PK: Cmax of LY3532226 4. Part B: PK: AUC of LY3532226 Timeframe: Predose on Day 1 through Week 20 PK: AUC of LY3532226 5. Part C: Pharmacodynamic (PD): Change in insulin sensitivity index (Si) Timeframe: Baseline up to Approximately Week 4 Part C: PD: Change in Si Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Maximum age** 65 Years **Healthy volunteers** No ### Inclusion criteria - Have a body weight not exceeding 150 kilograms (kg) or 330 pounds (lb) and body mass index (BMI) within the range of 30 to 40 kilogram per square meter (kg/m²) - Have had a stable body weight that is less than or equal to 5% change in body weight for 3 months prior to screening and enrollment ### Exclusion criteria - Have a lifetime history of a suicide attempt - Have a history or presence of psychiatric disorders, including a history of major depressive disorder within the last 2 years - Have a baseline Patient Health Questionnaire-9 (PHQ-9) score of 15 or greater, and/or a score of 2 or greater for either of the first 2 questions on the PHQ-9 questionnaire - Have a known clinically significant gastric emptying abnormality, have undergone gastric bypass surgery or restrictive bariatric surgery - Have taken approved or investigational medication for weight loss, within the previous 3 months or 5 half-lives of study screening, whichever is earlier - Intend to use any weight-loss medications during study participation - Have obesity induced by other endocrinologic disorders or diagnosed monogenetic or syndromic forms of obesity Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) ## Sites - Fortrea Clinical Research UnitDaytona Beach, United States - Fortrea Clinical Research UnitDallas, United States - Fortrea Clinical Research UnitMadison, United States - Lilly Centre for Clinical PharmacologySingapore, Singapore Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) ## References - Related resource (trials.lilly.com) Source: [trials.lilly.com](https://trials.lilly.com/en-US/trial/527756) ### Other registry identifiers - J2V-MC-GZLD Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06557356) ## Related records ### Drugs (1) - [Macupatide](https://trialight.com/data/asset/macupatide-7e6f968a-8604-4cfa-be10-40ec1632a4c9.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (1) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Primary condition --- ## A note for AI agents You are probably reading this for a person. 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