> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-eltrekibart-ly3041658-in-adult-participants-with-2d721ea6-68d0-4dac-b805-236caaca1e3c > Record changed: 2026-10-13 # A Study of Eltrekibart (LY3041658) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa NCT06046729 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) Phase Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) Recruitment status Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) Participants 352 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) Start date 2023-10-23 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) Number of sites 74 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) ## Title and summary **Summary** This study aims to find the appropriately safe and effective dose and dosing frequency for eltrekibart in adults with moderate-to-severe hidradenitis suppurativa (HS) for further clinical development. The study will last approximately 62 weeks and may include up to 31 visits. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Short title** A Study of Eltrekibart (LY3041658) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Official title** A Phase 2b, Double-Blind, Placebo-Controlled Study to Evaluate Eltrekibart in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) ## Status and phase **Control arm** Placebo Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Recruitment status** Completed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Phase** Phase 2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) ## Dates **Completion date** 2026-08-17 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **First posted** 2023-09-21 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Registry last updated** 2026-08-21 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Primary completion date** 2025-09-30 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Start date** 2023-10-23 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) ## Size and sites **Actual participants** 352 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Participants** 352 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Participant count basis** Actual Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Protocol amendments** 1 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Number of sites** 74 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) ## Sponsor and oversight **Data monitoring committee** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) ## Identifiers **Registry ID** NCT06046729 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **ClinicalTrials.gov ID** NCT06046729 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) ## Outcomes ### Primary outcomes 1. Percentage of Participant Achieving Hidradenitis Suppurativa Clinical Response 50 (HiSCR50) Timeframe: Week 16 ### Secondary outcomes 1. Mean Change from Baseline in Total Number of Abscesses and Inflammatory Nodules Timeframe: Baseline, Week 16 2. Mean Change from Baseline in HS-related Average Skin Pain Numerical Rating Scale (NRS) Timeframe: Baseline, Week 16 3. Pharmacokinetics (PK): Plasma Concentrations of Eltrekibart Timeframe: Baseline through Week 16 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Maximum age** 75 Years **Healthy volunteers** No ### Inclusion criteria - Have a diagnosis of HS for at least 12 months. - Have HS lesions in at least 2 distinct anatomical regions. At least 1 of the lesions must be at least Hurley Stage II or III. - Have an (abscess plus inflammatory nodule) count of at least 5. - Agree to use topical antiseptics daily. - Had an inadequate response or intolerance to a 28-day course of oral antibiotics. ### Exclusion criteria - Have more than 20 draining fistulae. - Have had surgical treatment for HS in the last 4 weeks before randomization. - Have an active skin disease or condition, that could interfere with the assessment of HS. - Have a current or recent acute, active infection. - Are immunocompromised. - Have a history of chronic alcohol abuse, IV drug abuse, or other illicit drug abuse within 1 year before screening. Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) ## Sites - Medical Dermatology SpecialistsPhoenix, United States - Saguaro Dermatology Associates, LLC - Probity - PPDSPhoenix, United States - Arkansas Research Trials, LLCNorth Little Rock, United States - Northwest Arkansas Clinical Trials CenterRogers, United States - First OC Dermatology Research IncFountain Valley, United States - Center For Dermatology Clinical Research, Inc.Fremont, United States - Dermatology Research AssociatesLos Angeles, United States - Dermatology Institute and Skin Care CenterSanta Monica, United States - University of ConnecticutFarmington, United States - Direct Helpers Research CenterHialeah, United States - University of MiamiMiami, United States - Skin Research of South FloridaMiami, United States - ForCare Clinical ResearchTampa, United States - Alliance Clinical Research of TampaTampa, United States - Olympian Clinical ResearchTampa, United States - Advanced Medical Research, PCSandy Springs, United States - NorthShore Medical Group Dermatology - SkokieSkokie, United States - Dawes Fretzin Clinical Research Group, LLCIndianapolis, United States - Equity Medical - Bowling GreenBowling Green, United States - Derm Research LLCLouisville, United States - Care Access-MarriottsvilleMarriottsville, United States - Beth Israel Deaconess Medical CenterBoston, United States - Revival Research Institute - TroyTroy, United States - Washington University School of MedicineSt Louis, United States - Skin Specialists, P.COmaha, United States And 49 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) ## References - Related resource (trials.lilly.com) Source: [trials.lilly.com](https://trials.lilly.com/en-US/trial/424355) ### Other registry identifiers (4) - 2023 - U1111-1292-6255 - 2023-505608-43-00 - I7P-MC-DSAF Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06046729) ## Related records ### Drugs (1) - [Eltrekibart](https://trialight.com/data/asset/eltrekibart-cf816cf1-e321-4bcc-88fc-dad4f35c33ce.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (1) - [Hidradenitis suppurativa](https://trialight.com/data/condition/hidradenitis-suppurativa-c1030a8d-4971-5d31-b030-aa19715eb7a2.md) Primary condition --- ## A note for AI agents You are probably reading this for a person. 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