> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/trial/a-study-of-eloratzp-in-adult-participants-with-obesity-or-7e99bbce-418a-44b5-996b-322989ad54ba > Record changed: 2026-11-04 # A Study of EloraTZP in Adult Participants With Obesity or Overweight and Type 2 Diabetes NCT07881458 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) Phase Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) Recruitment status Not yet recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) Participants 1,000 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) Lead sponsor Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) Start date 2026-11-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) Number of sites 75 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) ## Title and summary **Summary** The purpose of this study is to investigate the efficacy and safety of eloralintide and tirzepatide coformulation (EloraTZP) compared to tirzepatide for body weight reduction in participants with obesity or overweight and type 2 diabetes. Participation in the study will last about 2 years. Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Acronym** AMPLIFY-2 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Short title** A Study of EloraTZP in Adult Participants With Obesity or Overweight and Type 2 Diabetes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Official title** A Phase 3 Study to Investigate the Efficacy and Safety of LY900043 in Adult Participants With Obesity or Overweight and Type 2 Diabetes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) ## Status and phase **Registry reports results** No Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Listing at source** Listed Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Recruitment status** Not yet recruiting Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Phase** Phase 3 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Study type** Interventional Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) ## Dates **Completion date** 2029-11-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **First posted** 2026-10-19 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Registry last updated** 2026-10-19 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Primary completion date** 2029-10-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Start date** 2026-11-01 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) ## Size and sites **Participants** 1,000 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Participant count basis** Estimated Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Planned participants** 1,000 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Protocol amendments** 0 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Number of sites** 75 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) ## Sponsor and oversight **Data monitoring committee** Yes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Registry sponsor category** Industry Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Lead sponsor** Eli Lilly and Company Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Source registry** ClinicalTrials.gov Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) ## Identifiers **Registry ID** NCT07881458 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **ClinicalTrials.gov ID** NCT07881458 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) **Registry record** Open registry record Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) ## Study design **Allocation** Randomised **Model** Parallel groups **Purpose** Treatment **Masking** Double masking **Masked roles** Participants, Investigators Sources for study design Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) ## Outcomes ### Primary outcomes 1. Percent Change from Baseline in Body Weight Timeframe: Baseline, Week 100 ### Secondary outcomes 1. Change from Baseline in Waist Circumference Timeframe: Baseline, Week 100 2. Change from Baseline in Hemoglobin A1c (HbA1c) Timeframe: Baseline, Week 100 3. Change from Baseline in Systolic Blood Pressure Timeframe: Baseline, Week 100 4. Percent Change from Baseline in High-Sensitivity C-Reactive Protein (hsCRP) Timeframe: Baseline, Week 100 5. Percent Change from Baseline in Total Body Fat Mass Timeframe: Baseline, Week 100 6. Change from Baseline in Body Mass Index (BMI) Timeframe: Baseline, Week 100 7. Change from Baseline in Fasting Glucose Timeframe: Baseline, Week 100 8. Percentage of Participants who Achieve a Composite of Body Weight Reduction ≥ 15% and HbA1c <6.5% Timeframe: Week 100 9. Percent Change from Baseline in Total Cholesterol Timeframe: Baseline, Week 100 10. Percent Change from Baseline in Fasting Insulin Timeframe: Baseline, Week 100 11. Change from Baseline in Estimated Glomerular Filtration Rate (eGFR) Timeframe: Baseline, Week 100 12. Change from Baseline in Impact of Weight on Quality of Life-Lite Clinical Trials Version (IWQOL-Lite CT) Total Score Timeframe: Baseline, Week 100 13. Change from Baseline in EQ-5D-5L Score Timeframe: Baseline, Week 100 14. Change from Baseline in Eating Behaviors and Attitudes Questionnaire (EBAQ) Score Timeframe: Baseline, Week 100 15. Achievement of Improved Categorical Shift in Patient Global Impression of Severity (PGIS) Physical Function Weight Timeframe: Baseline, Week 100 16. Percentage of Participants with a Change in Medication Use Timeframe: Baseline, Week 100 17. Overall Functional Assessment of Chronic Illness Therapy, Item GP5 (FACT-GP5) Score Timeframe: Week 100 18. Pharmacokinetics (PK): Maximum Concentration of Eloralintide at Steady State (Cmax,ss) Timeframe: Baseline through Week 100 19. PK: Area Under the Concentration Versus Time Curve of Eloralintide for One Dosing Interval at Steady State (AUC(0-ᴛ)ss) Timeframe: Baseline through Week 100 20. PK: Maximum Concentration of Tirzepatide at Steady State (Cmax,ss) Timeframe: Baseline through Week 100 21. PK: Area Under the Concentration Versus Time Curve of Tirzepatide for One Dosing Interval at Steady State (AUC(0-ᴛ)ss) Timeframe: Baseline through Week 100 Sources for outcomes Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) ## Eligibility **Sex** All **Age groups** Adults, Older adults **Minimum age** 18 Years **Healthy volunteers** No ### Inclusion criteria - Have type 2 diabetes - Have a stable self-reported body weight (<5% body weight change) for 90 days prior to screening - Have a BMI of ≥27 kg/m2 at screening - Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight ### Exclusion criteria - Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening) - Have a prior or planned endoscopic procedure and/or device-based therapy for obesity and/or type 2 diabetes (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) - Have type 1 diabetes - Have taken any of the following within 90 days prior to screening - medications with direct amylin, glucagon-like peptide-1 (GLP-1) or glucagon-dependent insulinotropic polypeptide (GIP) receptor activity, including compounded therapies - dipeptidyl peptidase 4 (DPP-4) inhibitors, and - insulin - Have had within 90 days prior to screening: - heart attack - stroke - coronary artery revascularization - unstable angina, or - hospitalization due to congestive heart failure - Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure - Have taken medications or alternative remedies intended for weight loss within 90 days of screening Sources for eligibility Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) ## Sites - Tucson Clinical Research InstituteTucson, United States - Pacific Clinical Studies Inc.Los Alamitos, United States - Los Angeles Institute for Metabolic ResearchLos Angeles, United States - University of Colorado Anschutz Medical CampusAurora, United States - American Research Centers of FloridaPembroke Pines, United States - Encore Medical Research - WestonWeston, United States - Care Access - Dalton - Clinical Trials Center by Walmart & Care AccessDalton, United States - Pacific Diabetes & Endocrine CenterHonolulu, United States - DM Clinical Research - IndianapolisIndianapolis, United States - Care Access - EuniceEunice, United States - Tandem Clinical ResearchMarrero, United States - Care Access - St. LouisSt Louis, United States - IMA Clinical Research WarrenWarren Township, United States - NYC ResearchNew York, United States - IMA Clinical Research NYC MidtownNew York, United States - IMA Clinical Research AustinAustin, United States - Diabetes and Thyroid Center of Ft. WorthFort Worth, United States - Juno ResearchHouston, United States - Care Access - Houston - Clinical Trials Center by Walmart & Care AccessHouston, United States - ERA Health Research-TexasMidland, United States - Texas Valley Clinical Research (TVCR) - MissionMission, United States - IMA Clinical Research San AntonioSan Antonio, United States - Care Access - Tyler - Clinical Trials Center by Walmart & Care AccessTyler, United States - Washington Center for Weight Management and ResearchArlington, United States - Eastside Research AssociatesRedmond, United States And 50 more, listed on the interactive page. Sources for sites Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) ## References ### Other registry identifiers (2) - 2026-527230-31-00 - J7C-MC-YQAB Sources for references Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881458) ## Related records ### Drugs (1) - [Tirzepatide](https://trialight.com/data/asset/tirzepatide-eed85871-eb9c-4712-9102-badfdd99a720.md) ### Lead sponsors (1) - [Eli Lilly and Company](https://trialight.com/data/company/eli-lilly-and-company-9da7efcc-bafe-4b95-b30b-e87a97770db7.md) ### Conditions (2) - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Primary condition - [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) ### Targets (2) - [GIPR](https://trialight.com/data/target/gipr-5b65dd73-9875-5aca-be7a-5469a7290f0c.md) - [GLP1R](https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742.md) --- ## A note for AI agents You are probably reading this for a person. 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